Wound Healing After Tooth ExtractionNCT07898163
Comparing Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Early Healing After Tooth Extraction
A study testing Cross-linked sodium hyaluronate 1%, Non-cross-linked low-molecular-weight hyaluronic acid and Gelatin sponge in people with Wound Healing After Tooth Extraction, run by Cyprus Health and Social Sciences University at 1 site in Cyprus.
Trial summary
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Wound Healing After Tooth Extraction
- What is being tested?
- Cross-linked sodium hyaluronate 1%, Non-cross-linked low-molecular-weight hyaluronic acid and Gelatin sponge
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteCyprus
- Study dates
- 5 Oct 2026to 3 Nov 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age 18-45 years
- Systemically healthy
- Light smokers, instructed to abstain completely from smoking for the first 72 postoperative hours
- Requiring simple posterior tooth extraction
- Clinically achievable hemostasis
Who cannot join
- Systemic diseases affecting healing
- Pregnancy or lactation
- Acute infection at the extraction site
- Use of anti-inflammatory or immunosuppressive drugs
- Surgical extraction requiring flap elevation or bone removal
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Cross-Linked vs Non-Cross-Linked Hyaluronic Acid on Early Soft Tissue Healing After Tooth Extraction: A Randomized Blinded Clinical Trial
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.
- Conditions
- Wound Healing After Tooth Extraction
- Being tested
- Cross-linked sodium hyaluronate 1%, Non-cross-linked low-molecular-weight hyaluronic acid, Gelatin sponge
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cross-linked sodium hyaluronate 1%Drug
Cross-linked sodium hyaluronate 1% applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Non-cross-linked low-molecular-weight hyaluronic acidDevice
Non-cross-linked low-molecular-weight hyaluronic acid applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Gelatin spongeDevice
Gelatin sponge placed in the extraction socket without hyaluronic acid after non-surgical tooth extraction.
| Study group | Role | What they receive |
|---|---|---|
| Cross-Linked HA + Gelatin Sponge | Experimental | Participants receive cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction. Receives: Drug: Cross-linked sodium hyaluronate 1%; Device: Gelatin sponge |
| Non-Cross-Linked HA + Gelatin Sponge | Experimental | Participants receive non-cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction. Receives: Device: Non-cross-linked low-molecular-weight hyaluronic acid; Device: Gelatin sponge |
| Gelatin Sponge Alone | Active comparator | Participants receive a gelatin sponge alone after non-surgical tooth extraction. Receives: Device: Gelatin sponge |
What is being measured
The primary outcome is the main question the study is designed to answer.
ercentage Reduction in Wound Area
Wound area will be measured from standardized, calibrated clinical photographs using ImageJ. Percentage reduction will be calculated relative to baseline: [(baseline wound area - follow-up wound area) / baseline wound area] × 100. Results will be compared among the three groups over time.
Measured: Postoperative days 0, 3, 7, and 14
Secondary outcomes (4)
Wound Healing Score (WHS)
Clinical wound healing will be assessed using the study's WHS, with a total score ranging from 0 to 9.
Measured: Postoperative days 3, 7, and 14
Index of Postoperative Recovery (IPR)
Postoperative recovery will be assessed using the IPR measure specified in the study protocol.
Measured: Postoperative days 3, 7, and 14
Postoperative Pain Intensity
Pain intensity will be recorded using a 10-cm visual analogue scale (VAS), where 0 indicates no pain and 10 indicates the worst pain.
Measured: Postoperative days 1, 3, and 7
Postoperative Analgesic Consumption
The number of analgesic doses taken by each participant will be recorded in the postoperative medication log.
Measured: Postoperative days 1-7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2026
- Study start5 Oct 2026
- Primary completion3 Nov 2026
- Study completion3 Nov 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Wound Healing After Tooth ExtractionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cyprus Health and Social Sciences University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, omran nasab, Cyprus Health and Social Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07898163
- Sponsor's protocol ID
- KSTU//2026/026
- Status last verified
- Oct 2026
- First submitted
- 21 Oct 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Cross-Linked vs Non-Cross-Linked Hyaluronic Acid on Early Soft Tissue Healing After Tooth Extraction: A Randomized Blinded Clinical Trial
- ClinicalTrials.gov ID
- NCT07898163
- Acronym / sponsor ID
- KSTU//2026/026
- Conditions
- Wound Healing After Tooth Extraction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Cyprus Health and Social Sciences UniversityUniversity, hospital or other
- Study start
- 5 Oct 2026 (actual)
- Primary completion
- 3 Nov 2026 (actual)
- Study completion
- 3 Nov 2026 (actual)
- First posted
- 27 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Cross-Linked HA + Gelatin Sponge | Experimental | Drug: Cross-linked sodium hyaluronate 1%, Device: Gelatin spongeParticipants receive cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction. |
| Non-Cross-Linked HA + Gelatin Sponge | Experimental | Device: Non-cross-linked low-molecular-weight hyaluronic acid, Device: Gelatin spongeParticipants receive non-cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction. |
| Gelatin Sponge Alone | Active comparator | Device: Gelatin spongeParticipants receive a gelatin sponge alone after non-surgical tooth extraction. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age 18-45 years
- Systemically healthy
- Light smokers, instructed to abstain completely from smoking for the first 72 postoperative hours
- Requiring simple posterior tooth extraction
- Clinically achievable hemostasis
Key exclusion criteria (5 listed)
- Systemic diseases affecting healing
- Pregnancy or lactation
- Acute infection at the extraction site
- Use of anti-inflammatory or immunosuppressive drugs
- Surgical extraction requiring flap elevation or bone removal
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cross-linked sodium hyaluronate 1%Cross-linked sodium hyaluronate 1% applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction. | Drug | Cross-Linked HA + Gelatin Sponge |
| Non-cross-linked low-molecular-weight hyaluronic acidNon-cross-linked low-molecular-weight hyaluronic acid applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction. | Device | Non-Cross-Linked HA + Gelatin Sponge |
| Gelatin spongeGelatin sponge placed in the extraction socket without hyaluronic acid after non-surgical tooth extraction. | Device | Cross-Linked HA + Gelatin Sponge, Gelatin Sponge Alone, Non-Cross-Linked HA + Gelatin Sponge |
Primary outcome
ercentage Reduction in Wound Area
Time frame: Postoperative days 0, 3, 7, and 14
Wound area will be measured from standardized, calibrated clinical photographs using ImageJ. Percentage reduction will be calculated relative to baseline: [(baseline wound area - follow-up wound area) / baseline wound area] × 100. Results will be compared among the three groups over time.
4 secondary outcomes
Wound Healing Score (WHS)
Time frame: Postoperative days 3, 7, and 14
Index of Postoperative Recovery (IPR)
Time frame: Postoperative days 3, 7, and 14
Postoperative Pain Intensity
Time frame: Postoperative days 1, 3, and 7
Postoperative Analgesic Consumption
Time frame: Postoperative days 1-7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cross-linked sodium hyaluronate 1%, Non-cross-linked low-molecular-weight hyaluronic acid and Gelatin sponge in people with Wound Healing After Tooth Extraction, run by Cyprus Health and Social Sciences University at 1 site in Cyprus.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Cyprus. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ercentage Reduction in Wound Area (time frame: Postoperative days 0, 3, 7, and 14). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.