HemodynamicsNCT07901023
Comparison of Mean Arterial Pressure After Endotracheal Intubation in Patients Undergoing Spine Surgery With Pre-emptive Nitroglycerine Versus Dexmedetomidine
A study testing Nitroglycerin (NTG) and Dexmedetomidine in people with Hemodynamics and Arterial Pressure, run by Mayo Hospital Lahore at 1 site in Pakistan.
Trial summary
This randomized controlled study compared nitroglycerine and dexmedetomidine for controlling blood pressure after insertion of a breathing tube in adults undergoing spine surgery under general anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Hemodynamics, Arterial Pressure
- What is being tested?
- Nitroglycerin (NTG) and Dexmedetomidine
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 10 Jan 2026to 10 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 18-60 years.
- Patients of either sex.
- Patients undergoing elective discectomy, laminectomy, or other spine surgery under general anesthesia.
- American Society of Anesthesiologists physical status class I or II.
Who cannot join
- Known or suspected allergy to dexmedetomidine.
- Patients with hypertension, diabetes mellitus, or cardiovascular disease.
- Patients with peripheral vascular disease.
Trial locations and contacts
1 site in 1 country.
About this study
This randomized controlled study compared nitroglycerine and dexmedetomidine for controlling blood pressure after insertion of a breathing tube in adults undergoing spine surgery under general anesthesia. The study hypothesis was that average blood pressure, measured as mean arterial pressure, differed between patients who received the two medicines.
The study included 80 patients aged 18-60 years at the Department of Anesthesia, King Edward Medical University and its affiliated hospital in Lahore, Pakistan. Patients were randomly assigned by a lottery method to two groups of 40. One group received nitroglycerine through an intravenous infusion, while the other received dexmedetomidine. Both groups received the same general anesthesia protocol. Blood pressure was recorded before anesthesia and five minutes after insertion of the breathing tube. The main outcome was mean arterial pressure at five minutes after tube insertion, which was compared between the two groups.
- Conditions
- Hemodynamics, Arterial Pressure
- Being tested
- Nitroglycerin (NTG), Dexmedetomidine
- Keywords
- Nitroglycerin, Dexmedetomidine, Mean arterial pressure, Intubation, Intratracheal, Spine surgery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nitroglycerin (NTG)Drug
Nitroglycerin was administered by intravenous infusion at 120 micrograms/kg/hour and titrated to the target mean arterial pressure.
DexmedetomidineDrug
Dexmedetomidine was administered intravenously, followed by a continuous infusion at 1.0 microgram/kg/hour, titrated to the target mean arterial pressure.
| Study group | Role | What they receive |
|---|---|---|
| Group A: Nitroglycerin | Active comparator | Forty participants received intravenous nitroglycerin during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg. Receives: Drug: Nitroglycerin (NTG) |
| Group B: Dexmedetomidine | Experimental | Forty participants received intravenous dexmedetomidine during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg. Receives: Drug: Dexmedetomidine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean Arterial Pressure
Mean arterial pressure was assessed using noninvasive blood pressure measurements and expressed in millimeters of mercury. It was calculated as [systolic blood pressure + (2 × diastolic blood pressure)] ÷ 3. Mean arterial pressure measured five minutes after endotracheal intubation was compared between the nitroglycerin and dexmedetomidine groups.
Measured: Five minutes after endotracheal intubation.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2026
- Study start10 Jan 2026
- Primary completion10 Jun 2026
- Study completion10 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HemodynamicsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Hospital Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Adeel Ahmed, Mayo Hospital Lahore
- Investigators
- Aymen Zahid, Principal investigator, Mayo Hospital Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07901023
- Sponsor's protocol ID
- Mayo10
- Status last verified
- Oct 2026
- First submitted
- 22 Oct 2026
- Last updated
- 28 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Mean Arterial Pressure After Endotracheal Intubation in Patients Undergoing Spine Surgery With Pre-emptive Nitroglycerine Versus Dexmedetomidine
- ClinicalTrials.gov ID
- NCT07901023
- Acronym / sponsor ID
- Mayo10
- Conditions
- Hemodynamics, Arterial Pressure
- Keywords
- Nitroglycerin, Dexmedetomidine, Mean arterial pressure, Intubation, Intratracheal, Spine surgery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Mayo Hospital LahoreUniversity, hospital or other
- Study start
- 10 Jan 2026 (actual)
- Primary completion
- 10 Jun 2026 (actual)
- Study completion
- 10 Jun 2026 (actual)
- First posted
- 28 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled study compared nitroglycerine and dexmedetomidine for controlling blood pressure after insertion of a breathing tube in adults undergoing spine surgery under general anesthesia. The study hypothesis was that average blood pressure, measured as mean arterial pressure, differed between patients who received the two medicines.
The study included 80 patients aged 18-60 years at the Department of Anesthesia, King Edward Medical University and its affiliated hospital in Lahore, Pakistan. Patients were randomly assigned by a lottery method to two groups of 40. One group received nitroglycerine through an intravenous infusion, while the other received dexmedetomidine. Both groups received the same general anesthesia protocol. Blood pressure was recorded before anesthesia and five minutes after insertion of the breathing tube. The main outcome was mean arterial pressure at five minutes after tube insertion, which was compared between the two groups.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A: Nitroglycerin | Active comparator | Drug: Nitroglycerin (NTG)Forty participants received intravenous nitroglycerin during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg. |
| Group B: Dexmedetomidine | Experimental | Drug: DexmedetomidineForty participants received intravenous dexmedetomidine during general anesthesia for elective spine surgery. The infusion was titrated to maintain mean arterial pressure between 60 and 70 mmHg. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Patients aged 18-60 years.
- Patients of either sex.
- Patients undergoing elective discectomy, laminectomy, or other spine surgery under general anesthesia.
- American Society of Anesthesiologists physical status class I or II.
Key exclusion criteria (3 listed)
- Known or suspected allergy to dexmedetomidine.
- Patients with hypertension, diabetes mellitus, or cardiovascular disease.
- Patients with peripheral vascular disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nitroglycerin (NTG)Nitroglycerin was administered by intravenous infusion at 120 micrograms/kg/hour and titrated to the target mean arterial pressure. | Drug | Group A: Nitroglycerin |
| DexmedetomidineDexmedetomidine was administered intravenously, followed by a continuous infusion at 1.0 microgram/kg/hour, titrated to the target mean arterial pressure. | Drug | Group B: Dexmedetomidine |
Primary outcome
Mean Arterial Pressure
Time frame: Five minutes after endotracheal intubation.
Mean arterial pressure was assessed using noninvasive blood pressure measurements and expressed in millimeters of mercury. It was calculated as [systolic blood pressure + (2 × diastolic blood pressure)] ÷ 3. Mean arterial pressure measured five minutes after endotracheal intubation was compared between the nitroglycerin and dexmedetomidine groups.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Aymen Zahid principal investigator
Mayo Hospital Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nitroglycerin (NTG) and Dexmedetomidine in people with Hemodynamics and Arterial Pressure, run by Mayo Hospital Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean Arterial Pressure (time frame: Five minutes after endotracheal intubation.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.