Compartment SyndromeBLAST-PCSNCT07911085
From Blast Injury to Multicompartment Dysfunction:
An observational study of Compartment Syndrome and Compartment Syndrome Nontraumatic Lower Extremity, run by Ukrainian Society of Regional Anesthesia and Pain Therapy at 1 site in Ukraine.
Trial summary
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect multiple body areas and whether they occur at the same time or one after another. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity
- How many people
- 100 participants
- Where
- 1 siteUkraine
- Study dates
- 24 Oct 2026to 24 Oct 2026
- How long will I take part?
- 3 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Study population: Patients with combat-related blast injuries treated at the participating study site(s) during the study period will form the source population. The cohort will include patients with and without documented polycompartment syndrome, allowing the frequency and pattern of compartment involvement to be described. The study population will be identified from existing medical records for the index hospitalization.
Who may be able to join
- Patients of any sex treated at a participating study site for a combat-related blast injury during the study period.
- The index hospitalization record is available for retrospective review.
Who cannot join
- Patients treated for trauma without a blast-related injury.
- Duplicate records for the same injury event; only the index hospitalization will be included.
- Records that do not contain sufficient information to confirm eligibility.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Ukraine1 site
Vinnitsya university hospital
Vinnytsia, Vinnitsa, 21018
Dmytro Dmytriiev, Phd, 0674309449, dmytrodmytriiev@gmail.com
About this study
Official title: From Blast Injury to Multicompartment Dysfunction: A Retrospective Cohort Study Protocol
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect multiple body areas and whether they occur at the same time or one after another. Researchers will examine records for signs involving the abdomen, chest, limbs, or head, and explore how these findings relate to injury severity, resuscitation, organ function, and patient outcomes. No treatment will be assigned as part of this study, and patient care will not be changed.
Read the detailed description
Polycompartment syndrome (PCS) refers to pressure-related dysfunction involving two or more anatomical compartments, either at the same time or in sequence. In severe blast trauma, direct tissue injury, hemorrhage, fractures, burns, swelling, and resuscitation may affect several regions. Assessing each region in isolation may not capture how these problems develop together or relate to organ dysfunction.
This retrospective cohort will use existing clinical records to describe compartment-related findings in patients treated for blast-related injuries. The review will consider documented assessments of the abdomen, thorax, extremities, and head, including pressure measurements when available, their timing, and associated organ dysfunction. It will also examine recorded injury characteristics, resuscitation, management, and clinical outcomes to identify patterns and associations.
Each region will be evaluated using its own clinical assessment criteria. Findings in one compartment will not, by themselves, be treated as evidence of dysfunction in another. The study will describe how often multiple compartments are involved and whether documented involvement is concurrent or sequential. Because this is a retrospective review, the analyses will depend on the completeness and consistency of information in the medical records.
- Conditions
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity, Compartment Syndromes, Blast Injury, Abdominal Compartment Syndrome
- Keywords
- Polycompartment Syndrome, Thoracic Compartment Syndrome, Blast Injury, Combat-Related Trauma, Compartment Syndrome, Abdominal Compartment Syndrome, Extremity Compartment Syndrome
- Medical subject headings
- Compartment Syndromes, Blast Injuries, Intra-Abdominal Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients With Blast-Related Trauma | Participants in this cohort are patients treated for blast-related trauma whose existing medical records will be reviewed for documented involvement of multiple anatomical compartments. Exposures of interest include injury characteristics, compartment-specific findings, and resuscitation documented during routine care. No intervention is assigned by the study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of Patients With Polycompartment Syndrome
Number and percentage of patients meeting the study's prespecified definition of compartment syndrome or pressure-related dysfunction in two or more anatomical compartments (abdomen, thorax, cranium, and/or extremity). Cases will be classified as concurrent or sequential when timing is documented.
Measured: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Secondary outcomes (3)
Distribution of Affected Anatomical Compartments
Frequency and percentage of patients with abdominal, thoracic, cranial, or extremity involvement, including documented combinations.
Measured: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Timing and Sequence of Compartment Involvement
Proportion of cases with simultaneous versus sequential involvement and, where documented, the time between the first and subsequent compartment involvement.
Measured: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
In-Hospital Clinical Outcomes
In-hospital clinical outcomes will be obtained from the medical record and reported separately. These will include in-hospital mortality, hospital length of stay, ICU admission and ICU length of stay, need for mechanical ventilation, and documented complications.
Measured: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Nov 2026
- Study start24 Oct 2026 (estimated)
- Primary completion24 Oct 2026
- Study completion24 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Compartment SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
- Target duration
- 3 Months
Sponsor and investigators
- Lead sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dmytro Dmytriiev, Ukrainian Society of Regional Anesthesia and Pain Therapy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07911085
- Sponsor's protocol ID
- 2410102026
- Acronym
- BLAST-PCS
- Status last verified
- Oct 2026
- First submitted
- 25 Oct 2026
- Last updated
- 2 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No individual participant data will be shared. This retrospective study involves sensitive health information related to combat injuries. Only aggregate, non-identifiable findings will be reported.
Study at a glance
From the registry record, last updated by the sponsor on 2 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- From Blast Injury to Multicompartment Dysfunction: A Retrospective Cohort Study Protocol
- ClinicalTrials.gov ID
- NCT07911085
- Acronym / sponsor ID
- BLAST-PCS / 2410102026
- Conditions
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity, Compartment Syndromes, Blast Injury, Abdominal Compartment Syndrome
- Keywords
- Polycompartment Syndrome, Thoracic Compartment Syndrome, Blast Injury, Combat-Related Trauma, Compartment Syndrome, Abdominal Compartment Syndrome, Extremity Compartment Syndrome
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Ukrainian Society of Regional Anesthesia and Pain TherapyUniversity, hospital or other
- Study start
- 24 Oct 2026 (estimated)
- Primary completion
- 24 Oct 2026 (actual)
- Study completion
- 24 Oct 2026 (estimated)
- First posted
- 2 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect multiple body areas and whether they occur at the same time or one after another. Researchers will examine records for signs involving the abdomen, chest, limbs, or head, and explore how these findings relate to injury severity, resuscitation, organ function, and patient outcomes. No treatment will be assigned as part of this study, and patient care will not be changed.
Detailed description
Polycompartment syndrome (PCS) refers to pressure-related dysfunction involving two or more anatomical compartments, either at the same time or in sequence. In severe blast trauma, direct tissue injury, hemorrhage, fractures, burns, swelling, and resuscitation may affect several regions. Assessing each region in isolation may not capture how these problems develop together or relate to organ dysfunction.
This retrospective cohort will use existing clinical records to describe compartment-related findings in patients treated for blast-related injuries. The review will consider documented assessments of the abdomen, thorax, extremities, and head, including pressure measurements when available, their timing, and associated organ dysfunction. It will also examine recorded injury characteristics, resuscitation, management, and clinical outcomes to identify patterns and associations.
Each region will be evaluated using its own clinical assessment criteria. Findings in one compartment will not, by themselves, be treated as evidence of dysfunction in another. The study will describe how often multiple compartments are involved and whether documented involvement is concurrent or sequential. Because this is a retrospective review, the analyses will depend on the completeness and consistency of information in the medical records.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 3 Months
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients With Blast-Related Trauma | – | –Participants in this cohort are patients treated for blast-related trauma whose existing medical records will be reviewed for documented involvement of multiple anatomical compartments. Exposures of interest include injury characteristics, compartment-specific findings, and resuscitation documented during routine care. No intervention is assigned by the study. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Patients with combat-related blast injuries treated at the participating study site(s) during the study period will form the source population. The cohort will include patients with and without documented polycompartment syndrome, allowing the frequency and pattern of compartment involvement to be described. The study population will be identified from existing medical records for the index hospitalization.
Key inclusion criteria (2 listed)
- Patients of any sex treated at a participating study site for a combat-related blast injury during the study period.
- The index hospitalization record is available for retrospective review.
Key exclusion criteria (3 listed)
- Patients treated for trauma without a blast-related injury.
- Duplicate records for the same injury event; only the index hospitalization will be included.
- Records that do not contain sufficient information to confirm eligibility.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Proportion of Patients With Polycompartment Syndrome
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Number and percentage of patients meeting the study's prespecified definition of compartment syndrome or pressure-related dysfunction in two or more anatomical compartments (abdomen, thorax, cranium, and/or extremity). Cases will be classified as concurrent or sequential when timing is documented.
3 secondary outcomes
Distribution of Affected Anatomical Compartments
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Timing and Sequence of Compartment Involvement
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
In-Hospital Clinical Outcomes
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Nov 2026.
- Individual participant dataSharing planned: No. No individual participant data will be shared. This retrospective study involves sensitive health information related to combat injuries. Only aggregate, non-identifiable findings will be reported.
Related trials for Compartment Syndrome
Recruiting
Physiotherapy or Fasciotomy as Treatment for Chronic Exertional Compartment Syndrome in the Lower Leg?
Compartment Syndrome Nontraumatic Lower Leg
RecruitingPhase 4
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
Hernia Abdominal Wall, Botox Injection
Not yet recruitingObservational study
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
Intra-Abdominal Hypertension, Respiratory Mechanics
Recruiting
MY01 Pressure Monitoring in Adolescent Tibia Fractures
Proximal Tibia Fracture, Tibial Shaft Fracture
Not yet recruitingObservational study
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
Acute Kidney Injury, Intra-Abdominal Hypertension
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Compartment Syndrome and Compartment Syndrome Nontraumatic Lower Extremity, run by Ukrainian Society of Regional Anesthesia and Pain Therapy at 1 site in Ukraine.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Ukraine. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dmytro Dmytriiev, PhD.Professor (0674309449, mddmytriiev@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of Patients With Polycompartment Syndrome (time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Nov 2026.