Clinical trials: Compartment Syndromes
Hernia Abdominal Wall, Botox Injection
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as "BOTOX®" (onabotulinumtoxinA) into the…
- Conditions
- Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome
- Trial name
- PRETOX (NCT07220382)
- Testing
- OnabotulinumtoxinA Injection, OnabotulinumtoxinA, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Cleveland Clinic
Proximal Tibia Fracture, Tibial Shaft Fracture
MY01 Pressure Monitoring in Adolescent Tibia Fractures
The goal of this clinical trial is to learn more about anterior leg compartment pressures in adolescents who have sustained tibia fractures.
- Conditions
- Proximal Tibia Fracture, Tibial Shaft Fracture, Acute Compartment Syndrome
- Trial name
- NCT07674043
- Testing
- Continuous Compartmental Pressure Monitor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Compartment Syndrome Traumatic Lower Extremity
BM-MNCs for Lower Extremity Compartment Syndrome Injury
This is a phase 1 study to assess safety and tolerability of intramuscular administration of two different doses of autologous bone marrow mononuclear cells (BM-MNCs) for treatment of lower extremity injury complicated by…
- Trial name
- NCT03880656
- Testing
- Intramuscular administration of autologous BM-MNCs
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Oregon Health and Science University
Intraabdominal Hypertension, Abdominal Compartment Syndrome
Comparison of Bladder Pressure Versus Regional Intestinal Tissue Oxygenation in Infants
The goal of this clinical trial is to learn more about intestinal regional oxygen saturation measurements made with near-infrared spectroscopy and bladder pressure measurements in infants without risk of intraabdominal…
- Trial name
- BPvsNIRS (NCT05971264)
- Testing
- Near infrared-spectroscopy
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Chronic Exertional Compartment Syndrome
Treatment of Lower Leg Anterolateral Chronic Exertional Compartment Syndrome With Intra-muscular Botulinum Injections.
The goal of this pilot triple-blind randomized clinical trial is to determine the effectiveness of intra-muscular botulism injection for treatment of lower leg anterolateral chronic exertional compartment syndrome (CECS).
- Trial name
- NCT05765071
- Testing
- Botulinum toxin A, Normal saline
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Abdominal Hypertension, Abdominal Compartment Syndrome
Updated Abdominal Compartment Society Consensus Definitions
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2.
- Trial name
- WSACS (NCT07563842)
- Testing
- Delphi study
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Compartment Syndrome Nontraumatic Lower Extremity
The Effects of Prolonged Head-Down Tilt Lithotomy Position on Lower Limb Haemodynamics
During certain bowel surgeries for cancer (colorectal surgery), individuals frequently have to be placed in a head-down position to enable surgeons have optimal access to the cancer site.
- Trial name
- HELP (NCT06036641)
- Testing
- NIRS monitoring, Laser Doppler flowmetry, Inflammatory and Oxidative stress biomarkers
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Portsmouth
Intracranial Pressure Increase, Abdominal Compartment Syndrome
Vasopressin in Intraabdominal Pressure Elevation
The aim of this study is to investigate any direct correlation between increased intrathoracic pressure, intraabdominal pressure and intracranial pressure, following a controlled elevation in intraabdominal pressure and…
- Trial name
- NCT03707054
- Testing
- Study Arm
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Compartment Syndrome Nontraumatic Lower Leg
Physiotherapy or Fasciotomy as Treatment for Chronic Exertional Compartment Syndrome in the Lower Leg?
It is hypothesized that physiotherapy including a change in running landing pattern and surgical fasciotomy are equally good as treatment options for chronic exertional compartment syndrome (CECS) of the anterior compartment of…
- Trial name
- NCT03584815
- Testing
- Surgery/Fasciotomy, Physiotherapy
- Where
- 2 sites in Denmark
- Volunteers
- 72 people
- Sponsor
- Bispebjerg Hospital
Chronic Exertional Compartment Syndrome
Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS)
Chronic Exertional Compartment Syndrome (CECS) in the lower leg is a debilitating condition in highly active individuals. Pain occurs in 1 or several leg compartments upon an exertional activity, typically running, that quickly…
- Trial name
- NCT04409600
- Testing
- Supervised Gait Retraining, Home Based Gait Retraining, Saline Injection
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Walter Reed National Military Medical Center
Abdominal Compartment Syndrome
Intraoperative Peak Airway Pressure Changes on Postoperative Pulmonary Function After Muscle Plication
An abdominal panniculus excision procedure is known as an abdominoplasty (panniculectomy). Musculofascial plication is a crucial aspect of abdominoplasty, especially for patients with significant divarication of the recti…
- Trial name
- NCT06291389
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication
Continuous Compartment Pressure Monitoring for Compartment Syndrome in VA-ECMO Patients
Acute compartment syndrome (ACS) is a surgical emergency that can develop in patients on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Compartment Syndrome of Leg, Extracorporeal Membrane Oxygenation Complication, Limb Ischemia, Limb Ischemia, Critical
- Trial name
- VA-ECMO (NCT05830721)
- Testing
- MY01 + Standard of Care, 14-Gauge Slit Catheter + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Johns Hopkins University
Compartment Syndrome of Leg
Chronic Exertional Compartment Syndrome (CECS) Treated With Abobotulinumtoxin A
Chronic Exertional Compartment Syndrome (CECS) is a painful condition affecting runners and it is caused by a reversible increase in pressure within a closed compartment in the leg.
- Trial name
- CECS (NCT05466539)
- Testing
- AbobotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Compartment Syndromes, Compartment Syndrome of Lower Leg
NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome
This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and…
- Conditions
- Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm
- Trial name
- NCT05672381
- Testing
- Lower extremity and/or upper extremity surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Compartment Syndrome, Fracture, Bone
Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)
The goal of this clinical trial is to learn if tissue ultrafiltration (TUF) catheters can reduce intramuscular pressure and prevent acute compartment syndrome (ACS) in adults ages 18-60 with severe proximal tibia or tibial shaft…
- Conditions
- Acute Compartment Syndrome, Fracture, Bone, Tibial Fractures
- Trial name
- NCT05889559
- Testing
- Tissue Ultrafiltration Catheters
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Major Extremity Trauma Research Consortium
Compartment Syndromes
Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?
Near infrared spectroscopy (NIRS), a technique that relies on differential absorption of infrared light to provide relative estimation of tissue oxygenation, has been successfully used to monitor perfusion of various tissues…
- Trial name
- NIRS (NCT06512870)
- Testing
- Near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Amputation, Compartment Syndromes
Our Emergency Fasciotomy and Amputation Experiences
Earthquakes are natural disasters that threaten human life and cause loss of life and property in a very short time. In our country, where a large part of the population faces the risk of earthquakes, unfortunately, destructive…
- Conditions
- Amputation, Compartment Syndromes, Earthquake
- Trial name
- Earthquakes (NCT06764446)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Ischemia Limb, Blood Circulation Disorder
Ischemia Detection During Development of Acute Compartment Syndrome
This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide…
- Conditions
- Ischemia Limb, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- IDEA (NCT06079255)
- Testing
- IscAlert sensor(s) in patient with risk of acute compartment syndrome
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Compartment Syndromes
ACS Monitoring Charité Berlin
Compartment syndrome is a very serious musculoskeletal disorder, which can lead to devastating consequences, such as limb amputation and life-threatening conditions.
- Trial name
- NCT06030635
- Testing
- Measurement of compartment compressibility using the CPMX1 device
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Compremium AG
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic