Alveolar Bone RegenerationNCT07918014
Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite
A study testing Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite and Heal spontaneously without placement of any grafting material in people with Alveolar Bone Regeneration and Advanced Platelet-Rich Fibrin, run by Kafrelsheikh University at 1 site in Egypt.
Trial summary
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with spontaneous socket healing. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Alveolar Bone Regeneration, Advanced Platelet-Rich Fibrin, Strontium-Doped Hydroxyapatite
- What is being tested?
- Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite and Heal spontaneously without placement of any grafting material
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Aug 2026to 1 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged between 18 and 60 years.
- Both male and female patients.
- Indicated for extraction of teeth with preservation of intact extraction sockets.
- Presence of adequate surrounding bone walls suitable for socket preservation.
- Good oral hygiene and acceptable plaque control.
- Systemically healthy patients or those with medically controlled conditions that do not interfere with bone healing.
- Ability and willingness to comply with the study protocol and follow-up visits.
Who cannot join
- Pregnancy or lactation.
- Current smokers or tobacco users.
- Uncontrolled diabetes mellitus or systemic diseases affecting bone metabolism or wound healing.
- History of radiotherapy or chemotherapy involving the head and neck region.
- Active acute infection at the extraction site.
- History of bisphosphonate therapy or long-term corticosteroid use.
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- Bleeding disorders or anticoagulant therapy contraindicating blood collection.
- Previous regenerative procedures at the intended surgical site within the preceding six months.
- Patients unable or unwilling to attend scheduled follow-up visits.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Kafr Elsheikh University
Kafr ash Shaykh, Kafr Elsheikh, 33516
Abdulkarim J Al-Jahed, B.Sc, 00201121618187, dr.abdulkareemaljahed@gmail.com
Mohammed M Hussein, MD
About this study
Official title: Evaluation of Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite: A Randomized Clinical Study
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with spontaneous socket healing.
Read the detailed description
Tooth extraction is one of the most common procedures performed in dental practice and is frequently followed by physiologic remodeling of the alveolar process.
Alveolar ridge preservation has therefore become an essential component of contemporary oral and maxillofacial surgery. Various techniques have been developed to minimize post-extraction bone loss, including the use of autogenous bone, allografts, xenografts, alloplastic materials, barrier membranes, and biologically active agents.
Advanced platelet-rich fibrin (A-PRF), a second-generation platelet concentrate prepared without anticoagulants or biochemical additives, forms a three-dimensional fibrin matrix enriched with platelets, leukocytes, and circulating stem cells.
Strontium-doped hydroxyapatite (Sr-HA) has emerged as a promising synthetic bone substitute because of its favorable osteoconductive and bioactive properties. Incorporation of strontium ions into the hydroxyapatite crystal lattice enhances bone remodeling by simultaneously stimulating osteoblastic activity and inhibiting osteoclastic bone resorption.
- Being tested
- Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite, Heal spontaneously without placement of any grafting material
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Advanced Platelet-Rich FibrinDrug
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction.
Advanced Platelet-Rich Fibrin combined with Strontium-Doped HydroxyapatiteDrug
Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation.
Heal spontaneously without placement of any grafting materialOther
Extraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct.
| Study group | Role | What they receive |
|---|---|---|
| Group I (Control Group) | Active comparator | Extraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct. Receives: Other: Heal spontaneously without placement of any grafting material |
| Group II (A-PRF Group) | Experimental | Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction. Receives: Drug: Advanced Platelet-Rich Fibrin |
| Group III (Combination Group) | Experimental | Extraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation. Receives: Drug: Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of bone density
Radiographic bone density within the extraction socket was assessed using cone-beam computed tomography (CBCT) and standardized image-analysis software by an examiner blinded to treatment allocation.
Measured: 6 months after tooth extraction
Secondary outcomes (3)
Change in Alveolar Ridge Width
Change in horizontal alveolar ridge width, measured in millimeters using cone-beam computed tomography (CBCT), relative to the immediate post-extraction baseline.
Measured: 6 months after tooth extraction
Change in Alveolar Ridge Height
Change in vertical alveolar ridge height, measured in millimeters using cone-beam computed tomography (CBCT), relative to the immediate post-extraction baseline.
Measured: 6 months after tooth extraction
Incidence of postoperative complications
Incidence of postoperative complications including edema, infection, graft exposure, and wound dehiscence were recorded.
Measured: 6 months after tooth extraction
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Nov 2026
- Study start1 Aug 2026
- Primary completion1 Dec 2027 (estimated)
- Study completion1 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone RegenerationStudies of the same condition, open and under way.
- More trials run by Kafrelsheikh UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kafrelsheikh University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abdulkareem Jamal Al-Jahed, Kafrelsheikh University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07918014
- Sponsor's protocol ID
- KFSIRB200-1112
- Status last verified
- Nov 2026
- First submitted
- 29 Oct 2026
- Last updated
- 5 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Alveolar Bone Regeneration Using Advanced Platelet-Rich Fibrin Combined With Strontium-Doped Hydroxyapatite: A Randomized Clinical Study
- ClinicalTrials.gov ID
- NCT07918014
- Acronym / sponsor ID
- KFSIRB200-1112
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Kafrelsheikh UniversityUniversity, hospital or other
- Study start
- 1 Aug 2026 (actual)
- Primary completion
- 1 Dec 2027 (estimated)
- Study completion
- 1 Dec 2027 (estimated)
- First posted
- 5 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effectiveness of advanced platelet-rich fibrin (A-PRF) combined with strontium-doped hydroxyapatite (Sr-HA) in enhancing alveolar bone regeneration following tooth extraction compared with spontaneous socket healing.
Detailed description
Tooth extraction is one of the most common procedures performed in dental practice and is frequently followed by physiologic remodeling of the alveolar process.
Alveolar ridge preservation has therefore become an essential component of contemporary oral and maxillofacial surgery. Various techniques have been developed to minimize post-extraction bone loss, including the use of autogenous bone, allografts, xenografts, alloplastic materials, barrier membranes, and biologically active agents.
Advanced platelet-rich fibrin (A-PRF), a second-generation platelet concentrate prepared without anticoagulants or biochemical additives, forms a three-dimensional fibrin matrix enriched with platelets, leukocytes, and circulating stem cells.
Strontium-doped hydroxyapatite (Sr-HA) has emerged as a promising synthetic bone substitute because of its favorable osteoconductive and bioactive properties. Incorporation of strontium ions into the hydroxyapatite crystal lattice enhances bone remodeling by simultaneously stimulating osteoblastic activity and inhibiting osteoclastic bone resorption.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group I (Control Group) | Active comparator | Other: Heal spontaneously without placement of any grafting materialExtraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct. |
| Group II (A-PRF Group) | Experimental | Drug: Advanced Platelet-Rich FibrinExtraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction. |
| Group III (Combination Group) | Experimental | Drug: Advanced Platelet-Rich Fibrin combined with Strontium-Doped HydroxyapatiteExtraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Patients aged between 18 and 60 years.
- Both male and female patients.
- Indicated for extraction of teeth with preservation of intact extraction sockets.
- Presence of adequate surrounding bone walls suitable for socket preservation.
- Good oral hygiene and acceptable plaque control.
Key exclusion criteria (9 listed)
- Pregnancy or lactation.
- Current smokers or tobacco users.
- Uncontrolled diabetes mellitus or systemic diseases affecting bone metabolism or wound healing.
- History of radiotherapy or chemotherapy involving the head and neck region.
- Active acute infection at the extraction site.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Advanced Platelet-Rich FibrinExtraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) alone following tooth extraction. | Drug | Group II (A-PRF Group) |
| Advanced Platelet-Rich Fibrin combined with Strontium-Doped HydroxyapatiteExtraction sockets received Advanced Platelet-Rich Fibrin (A-PRF) combined with Strontium-Doped Hydroxyapatite (Sr-HA) for alveolar ridge preservation. | Drug | Group III (Combination Group) |
| Heal spontaneously without placement of any grafting materialExtraction sockets is left to heal spontaneously without placement of any grafting material or biologic adjunct. | Other | Group I (Control Group) |
Primary outcome
Assessment of bone density
Time frame: 6 months after tooth extraction
Radiographic bone density within the extraction socket was assessed using cone-beam computed tomography (CBCT) and standardized image-analysis software by an examiner blinded to treatment allocation.
3 secondary outcomes
Change in Alveolar Ridge Width
Time frame: 6 months after tooth extraction
Change in Alveolar Ridge Height
Time frame: 6 months after tooth extraction
Incidence of postoperative complications
Time frame: 6 months after tooth extraction
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Related trials for Alveolar Bone Regeneration
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L-PRF Block vs Composite Graft for Horizontal Ridge Augmentation
Alveolar Ridge Resorption After Extraction, Alveolar Bone Loss
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Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy
Active, not recruitingObservational study
Long-Term Stability of Soft and Hard Tissues After Guided Bone Regeneration in the Maxillary Anterior Region
Alveolar Bone Deficiency
Not yet recruiting
Comparison of Three Autogenous Bone and Xenograft Ratios for Horizontal Ridge Augmentation
Horizontal Alveolar Ridge Deficiency
Not yet recruitingPhase 1/2
Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
Alveolar Ridge Augmentation, Bone Substitutes
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Advanced Platelet-Rich Fibrin, Advanced Platelet-Rich Fibrin combined with Strontium-Doped Hydroxyapatite and Heal spontaneously without placement of any grafting material in people with Alveolar Bone Regeneration and Advanced Platelet-Rich Fibrin, run by Kafrelsheikh University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abdulkarim J Al-Jahed, B.Sc (00201121618187, dr.abdulkareemaljahed@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of bone density (time frame: 6 months after tooth extraction). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.