Clinical trials: ACL Tears
ACL Tear
Safe Return to Play After ACL Reconstruction
Recent studies report that as few as 44% of athletes undergoing ACL reconstruction were able to return to their prior level of competitive level of sports.
- Trial name
- NCT04827264
- Testing
- Safe Return to Play Following ACL Reconstruction Checklist
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Rothman Institute Orthopaedics
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
ACL Tear
Augmentation of Anterior Cruciate Ligament Reconstruction Using Mesenchymal Stem Cells and Collagen Matrix Carrier
The goal of this observational study is to compare patient outcomes for reconstructive surgery of ACL tears. This study utilizes two randomized groups, one being the control group that receives standard ACL reconstructive…
- Trial name
- BioACL (NCT05582226)
- Testing
- ACL reconstruction, Mesenchymal stem cell implantation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Andrews Research & Education Foundation
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
Complete Tear, Knee, Anterior Cruciate Ligament, Rupture of Anterior Cruciate Ligament
Tibial Tunnel Placement for ACL Reconstruction
Although extensive research has been carried out on Anterior Cruciate Ligament (ACL) femoral tunnel placement, very little attention has been given to the tibial tunnel.
- Trial name
- NCT02374710
- Testing
- ACL Reconstruction: Anterior Tunnel, ACL Reconstruction: Posterior Tunnel
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Virginia
Anterior Cruciate Ligament Rupture
Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Ligament
The purpose of this study is to evaluate the accuracy of tunnel positions in anterior cruciate ligament reconstruction
- Trial name
- NCT01267435
- Testing
- Anterior cruciate ligament reconstruction
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Anterior Cruciate Ligament Rupture
RCT of PEP Program to Reduce ACL Injuries in Female Collegiate Soccer Players
This research study involves implementing and evaluating a physical training program specifically designed to reduce the risk of ligamentous knee injuries in female soccer players by incorporating proven neuromuscular and…
- Trial name
- NCT00140270
- Testing
- PEP program
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery
The purpose of this study is to explore patient outcomes associated with, the use of a 3D printed knee extender device, in conjunction with an at-home rehabilitation program, for patients who are performing knee rehabilitation…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06524349
- Testing
- 3D printed knee extender device
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Sanford Health
Anterior Cruciate Ligament Rupture
Femoral Tunnel Position on Conventional MRI After Anterior Cruciate Ligament Reconstruction-Transtibial Technique Versus Transportal Technique
The position of the femoral tunnel in anterior cruciate ligament (ACL) reconstruction has been assessed on three dimensional CT (3D-CT) scan or in cadaveric study.
- Trial name
- NCT01513434
- Testing
- transtibial technique, Transportal technique, anterior cruciate ligament reconstruction
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- National Police Hospital
Anterior Cruciate Ligament Tear, Meniscal Tear
Prospective Registry of Anterior Cruciate Ligament Reconstructions
The purpose of the study is to investigate factors that are associated with outcomes of injury to the anterior cruciate ligament (ACL) in the knee among patients who are undergoing surgical reconstruction.
- Conditions
- Anterior Cruciate Ligament Tear, Meniscal Tear, Cartilage Injury, Bone Bruising
- Trial name
- NCT04135950
- Where
- United States
- Volunteers
- 1,646 people
- Sponsor
- State University of New York at Buffalo
Rupture of Anterior Cruciate Ligament
The Effect of Early WBVT on Neuromuscular Control After ACLR
To investigate the effect of early WBVT on neuromuscular control after ACLR.
- Trial name
- WBVT (NCT01300182)
- Testing
- Whole body vibration therapy, Control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Rupture
Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace
The Investigators are studying the effect of an ACL reconstruction on return to play by capturing outcome measures and biomechanics information.
- Trial name
- NCT06294314
- Testing
- Fertilized ACL
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Marshall University
ACL Tear
Quadriceps Strengthening ACL Reconstruction
The purpose of this study is to characterize quadriceps function and squat biomechanics during the early strengthening phase in adolescent patients undergoing a standardized combined neuromuscular electrical stimulation (NMES)…
- Trial name
- ACL (NCT07015541)
- Testing
- NMES and BFR, Standard physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Rupture of Anterior Cruciate Ligament
Multicenter Orthopaedics Outcomes Network for ACL Reconstructions
The purpose of this study is to determine the effect of modifiable risk factors on knee function, osteoarthritis, and re-rupture of the anterior cruciate ligament (ACL) following ACL reconstruction.
- Trial name
- NCT00463099
- Where
- 8 sites in United States
- Volunteers
- 3,294 people
- Sponsor
- Vanderbilt University Medical Center
Anterior Cruciate Ligament Rupture
Cross Bracing Protocol Versus Surgery for Acute Anterior Cruciate Ligament Rupture
The aim of the EMBRACE clinical trial is to compare outcomes (knee pain, symptoms, function and quality of life) between people with anterior cruciate ligament (ACL) rupture who are managed with either a novel bracing protocol…
- Trial name
- EMBRACE (NCT06956339)
- Testing
- Early anterior cruciate ligament surgery, Novel bracing protocol
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- University of Melbourne
Knee Injury, ACL Injury
Reducing Disparities in Knee Arthroscopy for Adolescents
Hundreds of thousands of youth athletes require surgery for knee injuries annually. The incidence of operative knee injuries has skyrocketed, but surgery can be delayed due to late recognition and barriers, such as insurance…
- Conditions
- Knee Injury, ACL Injury, Meniscus Tear, Hispanic or Latino
- Trial name
- RED KARD (NCT07580625)
- Testing
- Educational program and patient navigator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Anterior Cruciate Ligament Rupture
Are Opioids Needed After ACL Reconstruction
As the public health sector continues to confront the opioid epidemic, orthopaedic surgeons must revisit pain management protocols to reduce unnecessary opioid prescriptions.
- Trial name
- NCT04285853
- Testing
- Oxycodone
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Emory University
Anterior Cruciate Ligament Tear
Anterior Cruciate Ligament (ACL) Reconstruction: Single Bundle Versus Double Bundle
ACL tear is a common injury among athletes. The recommended treatment includes reconstruction of the ligament. The common reconstruction technique is single bundle reconstruction.
- Trial name
- NCT01025895
- Testing
- acl reconstruction - double bundle technique, acle reconstruction - single bundle technique
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Anterior Cruciate Ligament Tear
IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Injury to the knee during sports participation often involves partial or full detachment of the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and inflammation.
- Trial name
- EASI ACL (NCT02930122)
- Testing
- anakinra (150mg), Saline intraarticularly
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cale Jacobs, PhD
Anterior Cruciate Ligament Rupture, Motor Imagery
Motor Imagery After Reconstruction of the Anterior Cruciate Ligament
The primary aim of this study is to investigate the effect of motor imagery training as an additional tool in the rehabilitation after anterior cruciate ligament reconstruction (ACLR).
- Trial name
- MIRACL (NCT05168033)
- Testing
- Motor imagery training, Classic rehabilitation
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Ghent