Clinical trials: AIS
Idiopathic Scoliosis
Vertebral Body Tethering Outcomes for Pediatric Idiopathic Scoliosis
This study will assess whether Anterior Vertebral Tethering is a safe and feasible method of anterior approach surgery for spinal deformity in pediatric idiopathic scoliosis.
- Trial name
- NCT03194568
- Testing
- Anterior Vertebral Tether
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Patrick Cahill, MD
Scoliosis, Idiopathic Scoliosis
Validation of a New Optimized Nighttime Providence Brace for Personalized Treatment of Adolescent Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT05001568
- Testing
- Immediate in-brace correction: Conventional Brace, Immediate in-brace correction: Optimized Brace, Long-term bracing: Conventional Brace
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- St. Justine's Hospital
Adolescent Idiopathic Scoliosis
Posterior Column Spinal Osteotomies in the Treatment of Adolescent Idiopathic Scoliosis
Background: Posterior column osteotomies (PCO) are routinely used to facilitate curve correction in surgical treatment of adolescent idiopathic scoliosis (AIS).
- Trial name
- ASPO (NCT05379868)
- Testing
- Posterior column osteotomy, No osteotomies
- Where
- 2 sites in Finland
- Volunteers
- 116 people
- Sponsor
- Turku University Hospital
Spinal Fusion, Adolescent Idiopathic Scoliosis
Low Dose Dexmedetomidine as a Postoperative Pain Adjunct
This randomized controlled trial examines whether the addition of a low-dose dexmedetomidine infusion to our current multimodal pain management plan decreases narcotic consumption and reduces side effects in adolescent patients…
- Trial name
- NCT06067893
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nichole Doyle
Idiopathic Scoliosis
Assessment of Dynamic Balance in Idiopathic Scoliosis Compared to Normal Subjects
The purpose of this study is to assess dynamic balance in females with adolescent idiopathic scoliosis compared to normal subjects.
- Trial name
- NCT06219772
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adolescent Idiopathic Scoliosis (AIS)
Validation of the Clinical Decision Support Systems (CDSS) Developed in the EU Horizon PREPARE Project in the Rehabilitative Treatment of Idiopathic Scoliosis
The study aims to validate both the predictive capacity and the clinical usability of the Clinical Decision Support System (CDSS) developed within the PREPARE project (European Union Grant Agreement 101080288 PREPARE…
- Trial name
- PREPARE (NCT07379593)
- Testing
- CDSS simulation, Focus group - clinicians, Focus group - patients
- Where
- Italy
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Adolescent Idiopathic Scoliosis (AIS)
Detection of Scoliosis
This study aims to evaluate whether plantar pressure data collected during standing and walking can be used with machine learning to support early detection of scoliosis in young people.
- Trial name
- NCT07581015
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College, London
Scoliosis
Impact of the Choice of the Distal Vertebral in the Surgery of the Thoracic Adolescent Idiopathic Scoliosis
The problem of choosing the supporting vertebra was the subject of several studies. They do not suggest as regards the techniques that are not currently used or with insufficient setback.
- Trial name
- VD-SIA (NCT02791776)
- Testing
- Scoliosis
- Where
- 16 sites in France, Lebanon
- Volunteers
- 157 people
- Sponsor
- Fondation Lenval
Scoliosis Idiopathic, Scoliosis; Adolescence
fNIRS-based Analysis and Evaluation of the Effect of Schroth Rehabilitation on Motor Functions in Adolescent Idiopathic Scoliosis (AIS)
This study investigates the effects of Schroth-based rehabilitation on cortical dynamics, body awareness, and quality of life in individuals with Adolescent Idiopathic Scoliosis (AIS).
- Trial name
- NCT06884150
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Adolescent Idiopathic Scoliosis
Efficacy of Scoliosis Specific Exercise in Patients With Adolescent Idiopathic Scoliosis During Bracing
The purpose of this study is to examine the effectiveness of Schroth scoliosis-specific exercises (SSE) on patients with adolescent idiopathic scoliosis (AIS) during bracing.
- Trial name
- NCT03305185
- Testing
- Schroth SSE with Bracing, Bracing alone
- Where
- Hong Kong
- Volunteers
- 98 people
- Sponsor
- The University of Hong Kong
Scoliosis
Predictive Progressive Factors of Adolescent Idiopathic Scoliosis
The hypothesis of this study is that progressive AIS is characterized by a disorder of orthostatic postural control. The analysis and the treatment of posturographic signal on computerized integrate force plates, coupled to…
- Trial name
- SCOLEVOL (NCT02862392)
- Where
- 4 sites in France
- Volunteers
- 95 people
- Sponsor
- Lille Catholic University
Adolescent Idiopathic Scoliosis
Posterior Spinal Fusion With Pedicle Screws vs. Anterior Vertebral Body Tethering in Adolescent Idiopathic Scoliosis
Background- Adolescent idiopathic scoliosis is the most common indication for major surgery in adolescents. The current standard of care for adolescent idiopathic scoliosis (AIS) with a curve magnitude of over 40-50˚ in…
- Trial name
- NCT04590807
- Testing
- Posterior spinal fusion with pedicle screws, Anterior vertebral body tethering
- Volunteers
- 70 people
- Sponsor
- Turku University Hospital
Adolescent Idiopathic Scoliosis
Application of Virtual Reality in Post-Operative Recovery of a Pediatric Scoliosis Patient Population
The purpose of this study is to assess the effect of virtual reality on subjective post-operative pain, total inpatient narcotic administration, and mobilization with physical therapy in pediatric patients who have undergone…
- Trial name
- NCT06101264
- Testing
- Control, Virtual Reality
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Connecticut Children's Medical Center
Opioid Free Anesthesia
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids.
- Trial name
- NCT07389096
- Testing
- Dexmedetomidine, Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nashwa Ahmed
Adolescent Idiopathic Scoliosis
Is Respiratory Muscle Strength, Peripheral Muscle Strength and Postural Control Affected in Scoliosis?
The vertebral column is a structure that transfers the weight of the head and torso to the lower extremity, provides trunk movements and protects the spinal cord.A three dimensional deformity involving lateral flexion of the…
- Trial name
- NCT05833425
- Testing
- Respiratory Pressure Meter (MicroRPM)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Adolescent Idiopathic Scoliosis, Posterior Spinal Fusion
Return to Sport After Posterior Spinal Fusion
The primary purpose of this prospective study is to determine when adolescent athletes with idiopathic scoliosis are able to return to sports participation after posterior spinal fusion surgery.
- Trial name
- NCT03513120
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Scoliosis; Adolescence
Conservative Management for Adolescent Idiopathic Scoliosis
Idiopathic scoliosis is a living problem that resists correction. The underlying cause of the such disorder is unknown but directed more toward muscular disorders.
- Trial name
- NCT05819034
- Testing
- Scoliosis-Specific Exercise Program, Soft orthoses with external strapping.
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Umm Al-Qura University
Adolescent Idiopathic Scoliosis
Intraoperative Cell Salvage and Hemodilution Technique in Scoliosis Surgery
Surgical correction of scoliosis with instrumentation carries significant blood loss and needs for blood transfusion with its inherent risk and cost.
- Trial name
- NCT02112409
- Testing
- cell salvage technique, acute normovolemic hemodilution
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- University of Malaya
Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis
Kids With Iron Deficiency and Scoliosis
This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and…
- Conditions
- Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis, Perioperative/Postoperative Complications, Iron Deficiencies
- Trial name
- KIDS (NCT06042699)
- Testing
- Oral ferrous sulfate
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
Back Pain, Scoliosis
Back Pain and Spinal Manipulation in Adolescent Scoliosis
Adolescent idiopathic scoliosis (AIS) affects 2 - 3% of children and adolescents older than 10 years and is of unknown cause. It was initially thought that occurrences of back pain (BP) were similar to the one encounter in…
- Trial name
- NCT02609009
- Testing
- Spinal Manipulation Therapy, Usual Medical Care
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital