Clinical trials: Acute Respiratory Failure
Acute Renal Failure (ARF), Acute Tubular Necrosis
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
- Trial name
- QRX3 in ARF (NCT07161843)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ebima Clifford Okundaye
Acute Respiratory Distress Syndrome
PEEP Test and Gas Exchange in ALI/ARDS Patients
The investigators aim to study the effect of different levels of PEEP in ALI/ARDS patients on gas exchange.
- Trial name
- NCT00284102
- Testing
- Mechanical ventilation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Hospital
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Respiratory Failure, Mechanical Ventilation
Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study
Despite its life-saving potential, the mechanical ventilator has great potential to do harm. Despite years of research, the mortality in acute lung injury (ALI) remains very high.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Acute Lung Injury
- Trial name
- NCT01628523
- Testing
- For inclusion in the study, patients will have to require mechanical ventilation either via an endotracheal tube or tracheostomy tube.
- Where
- 4 sites in United States
- Volunteers
- 219 people
- Sponsor
- Washington University School of Medicine
Respiratory Failure
Closed-Loop O2 Use During Invasive Mechanical Ventilation Of Pediatric Patients
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Trial name
- CLOUDIMPP (NCT05714527)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Rhinitis, Nasal Obstruction
Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction
The purpose of this post-market clinical investigation is to assess the performance and the safety of the mechanical decongestant seawater spray enriched with essential oils from Laboratoires Gilbert.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEMECA (NCT06580210)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- Laboratoires Gilbert
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
Closed-loop Synchronization Versus Conventional Synchronization
A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient.
- Trial name
- CHESTSIPP (NCT05731024)
- Testing
- close-loop synchronization controller with SPONT mode, Conventional synchronization settings with SPONT mode
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Hypoxemic Respiratory Failure
HFNC and Prone Positioning in Awake Patients With Severe COVID-19
The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.
- Trial name
- NCT04982341
- Testing
- prone position
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
Acute Respiratory Distress Syndrome, Severe Pneumonia
One Year Follow-ups of Patients Admitted to Spanish Intensive Care Units Due to COVID-19
The latest epidemiological data published from Chine reports that up to 30% of hospital-admitted patients required admission to intensive care units (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Severe Pneumonia, Respiratory Failure
- Trial name
- NCT04457505
- Where
- 31 sites in Spain
- Volunteers
- 8,500 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Acute Coronary Syndrome, Heart Failure
A Survey of Hospitalizations in Cardiology Units in Sub-Saharan Africa
FEVRIER study is an observatory of hospitalizations in cardiology units in sub-Saharan Africa.
- Conditions
- Acute Coronary Syndrome, Heart Failure, Syncope, Stroke
- Trial name
- FEVRIER (NCT03231449)
- Testing
- observation of current care
- Where
- 20 sites in Benin, Burkina Faso and 11 more
- Volunteers
- 5,000 people
- Sponsor
- Cardiologie et Développement
Bronchiolitis, Respiratory Syncytial Virus (RSV)
High Flow Nasal Cannula Therapy in Bronchiolitis : Early vs Rescue
The enrolled RSV-bronchiolitis patients will be randomized into two arms , the early HHHFNC group and the standard therapy group with rescue HHHFNC to study the efficacy of this treatment.
- Trial name
- NCT03095495
- Testing
- Heated Humidified High Flow Nasal Cannula, Standard Therapy (Low Flow Nasal Cannula)
- Where
- Qatar
- Volunteers
- 28 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Failure, ECMO
Cardinality Matching Study of Early v.s. Delayed VV ECMO in Severe Respiratory Failure
Clinical reasoning and recent data suggest that early use of venovenous extracorporeal membrane oxygenation in refractory respiratory failure may confer a survival advantage.
- Trial name
- NCT03981393
- Volunteers
- 667 people
- Sponsor
- University of Cambridge
Mechanical Ventilation
Evaluation of the Patient-ventilator Asynchrony During Mechanical Ventilation for Pediatric Acute Respiratory Failure
The synchronization between the patient and the ventilator is an essential objective during mechanical ventilation (MV). Maintaining the patient's respiratory activity during MV reduces ventilation pressures, improves…
- Trial name
- Asynchrony (NCT03138148)
- Testing
- Routine mechanical ventilation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Failure (ARF), Non Invasive Ventilation (NIV)
Music Therapy During NIV Implantation in Pediatric Intensive Care Units
Non-invasive ventilation makes it possible to avoid intubation and improve patients' quality of life. However, pain is associated with discomfort and could lead to failure of this technique.
- Trial name
- MusiNIV (NCT06848218)
- Testing
- Music Therapy, Setting Up NIV
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
Community Acquired Pneumonia
Clinical Pediatric Pneumonia Score in Critically Ill Children
The purpose of the study is to create a clinical pneumonia tool that can be used to predict the cause of community-acquired pneumonia, which is a lung infection that began outside of the hospital in critically ill children…
- Trial name
- NCT02139384
- Where
- United States
- Sponsor
- Loma Linda University
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Pneumnia, Chest Infection
Use of Simplified Lung Ultrasound Score for Predicting ICU Outcomes in Patients With Acute Respiratory Failure
This study aims to Primary Aims: Verify the predictability of the PLIS at admission in predicting major clinical outcomes including: ICU mortality (or discharge) and time to death (or discharge) Escalation of ventilatory support…
- Conditions
- Pneumnia, Chest Infection, Critically-ill Patients Admitted to the ICU for Acute Respitatory Failure, Regardless the Aetilogy
- Trial name
- NCT06678035
- Volunteers
- 72 people
- Sponsor
- Assiut University
Acute Respiratory Failure With Hypoxia, Malnutrition
Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
Optimal delivery of nutritional support during critical illness is central to appropriate intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing, route, dose, and type of nutritional support…
- Trial name
- SuPPeR (NCT01937884)
- Testing
- Parenteral Nutrition
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Arizona
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
Angina Pectoris, Acute Coronary Syndrome
Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19
Management of known patients with cardiovascular disease (in particular the whole spectrum of atherosclerotic ischaemic coronary artery disease, essential hypertension under treatment, and also patients with chronic heart failure…
- Conditions
- Angina Pectoris, Acute Coronary Syndrome, Coronary Syndrome, Coronary Artery Disease
- Trial name
- eCardioCovid19 (NCT04325867)
- Testing
- Tele-medicine platform
- Where
- 2 sites in Romania
- Volunteers
- 200 people
- Sponsor
- Professor Adrian Covic