Clinical trials: Administration, Topical
Oral Aphthous Ulcer
Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer
Recurrent oral aphthous ulcer is the most common oral lesion in occurrence and one of cause is oxidative stress so investigators need to use antioxidant drugs like topical coenzyme Q10 gel to treat the lesion and more safe for…
- Trial name
- NCT03213769
- Testing
- topical coenzyme Q10 gel, Carpabol gel
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Oral Lichen Planus
Effect of Adjunctive Systemic Vitamin E on Clinical Parameters and Salivary Total Antioxidant Capacity in Symptomatic Oral Lichen Planus Patients: Randomized-controlled Clinical Trial
Treatment of oral lichen planus is challenging. Diverse therapeutic modalities have been suggested, but a permanent cure is not yet available.
- Trial name
- NCT04126720
- Testing
- topical corticosteroids and vitamin E suplements
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Anesthesia, Local
Lidocaine Administration Using STAR Particles
This study is being done to answer the question: Do STAR particles (tiny pieces of ceramic with small spikes) help numbing gel (a gel that helps you feel less pain) work more quickly to provide local anesthesia or numbing in a…
- Trial name
- NCT06034340
- Testing
- LET Gel after STAR Particle Application (Right or Left Arm), LET Gel Application without STAR Particle Application (Contralateral Arm)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Emory University
Skin Aging
Efficacy of Extract of Trigonella Foenum-graceum as Topical Phytoestrogen in Skin Aging Treatment of Post Menopausal Women
Skin is subjected to intrinsic aging and extrinsic aging. Intrinsic aging is influenced by genetic and hormonal factors. Estrogen has significant role in modulating skin physiology.
- Trial name
- NCT04123743
- Testing
- Trigonella foenum-graceum extract topical cream, Facial Wash, Sunscreen Cream
- Where
- Indonesia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acne Vulgaris
Efficacy and Tolerability Evaluation of a Novel Dermo-cosmetic Product for Mild-to-moderate Acne
The goal of this non-interventional, observational study is to evaluate the real-world efficacy and tolerance of a novel dermocosmetic cream containing 15% Azelaic acid and a complex of active ingredients (α-AZ cream) in patients…
- Trial name
- NCT07759505
- Where
- Romania
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ISISPHARMA
Atopic Dermatitis
Improvement of Short Term Outcome of Mild to Moderate Atopic Dermatitis Using a Combination of Crisaborole and a Concomitant Topical Corticosteroid Over a 8 Week Period
This trial is a single-center two arm, open label observational prospective study, that will evaluate the safety and efficacy of crisaborole ointment, 2% alone compared to a combination therapy of crisaborole and a topical…
- Trial name
- NCT04008784
- Testing
- Crisaborole 2% Topical Application Ointment [EUCRISA], Triamcinolone Acetonide 0.1% Ointment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clinical Research Center of the Carolinas
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Dermatology, Female Pattern Baldness
Efficacy and Safety of Topical Vitamin D Analogue in Treatment of Female Pattern Hair Loss
The trial aims to study efficay of topical vitamin D analogue in treatment of female pattern hair loss cases
- Trial name
- NCT06333600
- Testing
- Topical minoxidil, Topical Vitamin D, Saline spray
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University
Topical Corticosteroid, Topical, Medication, Utilization
Topical Corticosteroid App
The study aims to evaluate the effectiveness of a mobile application to assist in the prescription of topical corticosteroids (TCS), focusing on best fit choices of potency, vehicle and volume.
- Trial name
- NCT02921503
- Testing
- mobile topical corticosteroid app
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Acne Vulgaris
Vitamin A and Azithromycin for Acne Vulgaris
Patients seen with acne lesions not having responded to existing treatments will be offered a placebo or a topical preparation consisting of Vitamin A USP with or without Azithromycin for a duration of 4-6 months USP for the…
- Trial name
- NCT03090048
- Testing
- Vitamin A, Azithromycin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Manchanda Medical Clinic
Vitiligo - Macular Depigmentation
Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"
This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.
- Trial name
- NCT07548918
- Testing
- microneedling with minoxidil 5% and NBUVB, Microneedling with Minoxidil5%
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Plaque Psoriasis
An Open Label, Safety Study to Assess the Potential for Adrenal Suppression
An Open Label, Safety Study to Assess the Potential for Adrenal Suppression Following Treatment with DSXS (Taro Pharmaceuticals U.S.A., Inc.) in Patients with Plaque Psoriasis
- Trial name
- NCT02932878
- Testing
- DSXS topical
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Allergic Conjunctivitis
Effectiveness of PR013 Topical Ophthalmic Drops Compared to Vehicle for the Treatment of Allergic Conjunctivitis
To evaluate the efficacy and safety of PR013 topical ophthalmic drops (0.045% and 0.06%) compared to vehicle for the treatment of the signs and symptoms of allergic conjunctivitis using a modified Conjunctival Allergen Challenge…
- Trial name
- NCT03368339
- Testing
- PR013 (0.045%), PR013 (0.06%), Vehicle
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Realm Therapeutics, Inc.
Vitiligo, Generalized
Evaluation Safety ,Efficacy Baricitinib Plus Excimer Light Versus Excimer Light Alone in Non Segmental Vitiligo
The study aims to evaluate the safety and efficacy of the combination of topical baricitinib and 308-nm monochromatic excimer light versus 308-nm monochromatic excimer light alone in treatment of non-segmental vitiligo.
- Trial name
- NCT05950542
- Testing
- Baricitinib
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Molluscum Contagiosum
Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum
The purpose of this study is to determine if cantharidin is a safe and effective treatment for molluscum contagiosum in kids
- Trial name
- NCT02665260
- Testing
- Cantharidin, Gauze occlusion bandage
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Oral Lichen Planus
Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial
The aim of the present investigation is to assess the clinical therapeutic effect of topical use of Coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus and determine whether the effect, if…
- Trial name
- NCT04091698
- Testing
- Co-Enzyme Q10 mucoadhesive tablets
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Efficacy of Subgingivally Delivered Doxycycline Plus Ketoprofen Gel as an Adjunct to Non-surgical Periodontal Treatment
Objectives: The aim of the present clinical study was to evaluate the efficacy of doxycyline 3% plus ketoprofen 2.5% as an adjunct to scaling and root planing in the treatment of chronic periodontitis(early-modearte).
- Trial name
- NCT02538224
- Testing
- 2.5%ketoprofen gel + 3 % doxycycline, :2.5%ketoprofen gel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Oral Lichen Planus
The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients
Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus. Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva.
- Trial name
- NCT03877679
- Testing
- Triamcinolone, Turmeric paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hidradenitis Suppurativa
An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.
The purpose of this study is to compare the efficacy of Provodine™ topical cream to 10% benzoyl peroxide topical body wash for the treatment of early stage hidradenitis suppurativa.
- Trial name
- NCT01818167
- Testing
- 10% Benzoyl Peroxide Topical Body Wash, Provodine Topical Cream
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Otomycosis
Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment
Background and Objectives To compare the efficacy of gel foam-soaked pyodine with a single topical application of clotrimazole ointment.
- Trial name
- NCT06339294
- Testing
- Clotrimazole Cream, Povidone-Iodine
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College