Clinical trials: Adult Depression
Depression, HIV
Implementation of a Collaborative Care Model to Manage Depression Among Adolescents and Young Adults in HIV Services in Thailand
This study aims to investigate the acceptability and feasibility of the implementation of a collaborative care model (CCM) to screen and treat depression.
- Trial name
- NCT05006625
- Testing
- Collaborative Care Model
- Where
- Thailand
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
LGBTQ, Sexual Behavior
A Trial of Online LGBTQ-affirmative Cognitive Behavioral Therapy to Reduce Depression and Associated Health Risks Among Young Adults
This study is to test the efficacy of an online CBT intervention (EQuIP) that addresses the pathways through which minority stress compromises LGBTQ young adults' co-occurring mental (e.g., depression) and behavioral (e.g.…
- Trial name
- NCT04408469
- Testing
- Online EQuIP, Self-monitoring control
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Adolescent Cancer Survivors, Childhood Cancer Survivors
IMpact of Mind-body Therapies (HYpnosis and Relaxation) on Anxiety in Children, Adolescents and Young Adults Who Had Been Treated in ONcology. Multicenter Study.
In France today, it is estimated that one in 850 people aged between 20 and 45 has been cured of cancer in childhood. Some descriptive studies have established that cancer diagnosis and treatment can affect psychological health…
- Conditions
- Adolescent Cancer Survivors, Childhood Cancer Survivors, Anxiety
- Trial name
- HARMONY-Impact (NCT07380672)
- Testing
- 10 mind-body therapy sessions (hypnosis or relaxation, depending on the patient's choice), 9 sessions of standard psychological care
- Where
- 5 sites in France
- Volunteers
- 558 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Depression
Reducing the Risk of Developing Major Depression in Adolescents/Young Adults With Minor Depression/Depression Symptoms
The purpose of this research study is to assess the feasibility of a combined primary care/web-based depression prevention intervention.
- Trial name
- NCT00145951
- Testing
- motivational interviewing, brief advice in primary care
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Depression
Probiotic Administration for Adolescent Depression
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
- Trial name
- PAD (NCT06898788)
- Testing
- Visbiome
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of California, San Francisco
Depression, Cancer
Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit
Our team has developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression.
- Conditions
- Depression, Cancer, Adolescent, Young Adult
- Trial name
- ASCENT (NCT07173205)
- Testing
- AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
- Where
- 2 sites in United States
- Volunteers
- 208 people
- Sponsor
- East Carolina University
Major Depressive Disorder
Eealy Improvement Predicts Antidepressants Response in Adults With Major Depression Disorder
Early improvemrnt, decreased 20% in the 17 items of Hamilton Depression Rating Scale (HAMD-17) at the second week of the treatment of major depression disorder (MDD), can arguably predict the remission at the 12th week.
- Trial name
- NCT03230682
- Testing
- antidepressant
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Huashan Hospital
Mood Disorder, Neurobehavioral Manifestation
Adolescence, Puberty, and Emotion Regulation
The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses.
- Conditions
- Mood Disorder, Neurobehavioral Manifestation, Healthy
- Trial name
- NCT00016731
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Symptoms
Efficacity of Psychological Intervention on Reducing the Suicidal Ideations, Depression Level and Improving Reinsertion
Suicide is the third leading cause of death in adolescents and young adults in the United States and the second leading cause in European countries.
- Trial name
- MLADO (NCT03655730)
- Testing
- weekly psychotherapeutic individual sessions, Usual care
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Depression, Anxiety
Identification of Anxiety and Depression in Adolescents/Young Adults (AYA) With Cancer
This is a prospective, multisite (but all within the UTSW IRB), observational study assessing the relationship of hope to anxiety and depression, QoL, and social support over time in the first year after cancer diagnosis or…
- Trial name
- NCT04589052
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Eating Disorders
Implementation of Project YES in Ambulatory Adolescent & Young Adult Medicine
This study tests a suite of single-session intervention (SSI) targeting risk factors for depression and eating disorders among adolescents and young adults.
- Conditions
- Depression, Eating Disorders, Anxiety
- Trial name
- NCT06359951
- Testing
- Project YES
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Cancer, Bone Marrow Neoplasms
The PRISM Intervention for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation
Multisite Randomized Controlled Trial (RCT) testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults receiving hematopoietic cell transplantation for hematology…
- Conditions
- Cancer, Bone Marrow Neoplasms, Anxiety, Depression
- Trial name
- NCT03640325
- Testing
- PRISM (Promoting Resilience in Stress Management)
- Where
- 5 sites in United States
- Volunteers
- 143 people
- Sponsor
- Seattle Children's Hospital
Bipolar Disorder, Major Depressive Disorder
Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms
The purpose of this study is to advance a non-pharmacologic suicide preventive intervention with wide dissemination potential as an innovative high-yield solution to reduce suicide rates.
- Conditions
- Bipolar Disorder, Major Depressive Disorder, Mood Disorders, Suicide
- Trial name
- NCT05317481
- Testing
- BE-SMART-DR, psychoeducational control comparator condition (CC)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Anxiety Depression
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH
The goal of this clinical trial will be to evaluate the efficacy of an AI-informed peer-mentoring program to improve stress management and social skills and reduce the risk of depressive and anxiety symptoms in healthy…
- Trial name
- PeerMentorAnxD (NCT07472894)
- Testing
- Peer-mentoring behavioral intervention, Health Education
- Where
- 2 sites in Greece, Italy
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- University of Patras
Depression in Adolescence, Depression in Adults
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in…
- Trial name
- NCT05712772
- Testing
- Blue Light, Red Light
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Suicidal Behavior, Self-Harm, Deliberate
Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
This randomized controlled trial will evaluate two approaches to achieving the aspirational goal of Zero Suicide within a health system: 1) Zero Suicide Best Practices initiated through a zero suicide quality improvement…
- Conditions
- Suicidal Behavior, Self-Harm, Deliberate, Suicidal Ideation, Suicide
- Trial name
- Step2Health (NCT03092271)
- Testing
- Stepped Care for Suicide Prevention, Zero Suicide Quality Improvement
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
rTMS for Adolescents and Young Adults
rTMS is a promising, though largely untested, option for treating adolescent and young adult depression. This study hypothesizes that rTMS will safely and significantly alleviate depression and decrease suicidal ideation in…
- Trial name
- JHU (NCT00984087)
- Testing
- TMS with Neurostar TMS Therapy System
- Where
- United States
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases, Hypertension
Impact of Sleep Disordered Breathing in Older Adults
To test the hypothesis that clinically inapparent sleep-disordered breathing was associated with blood pressure elevation, impairment of health-related quality of life, and depression.
- Conditions
- Cardiovascular Diseases, Hypertension, Depression, Sleep Apnea Syndromes
- Trial name
- NCT00005378
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Suicide, Suicide, Attempted
Suicide Prevention Among Recipients of Care
Randomized controlled trial to determine the best brief suicide prevention intervention for adults and adolescents who screen positive for suicidal ideation or behavior in emergency departments or primary care clinics.
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Social Support
- Trial name
- SPARC (NCT04893447)
- Testing
- SPI+, SP+CC (Caring Contacts)
- Where
- United States
- Volunteers
- 1,520 people
- Sponsor
- St. Luke's Health System, Boise, Idaho