Clinical trials: Antibiotic Resistance, Microbial
Urinary Tract Infection Empiric Antibiotic
Does the National Health Insurance Card Allow us to Predict Antibiotic Resistance?
The objective is to determine if data from the National Insurance Health card (giving antibiotics and hospitalizations in the past 18 months) allow to predict the individual risk of antibiotic resistance and to identify…
- Trial name
- NCT02292160
- Where
- 2 sites in France
- Volunteers
- 1,128 people
- Sponsor
- University Hospital, Rouen
Bacterial Infections
New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)
This study will treat pediatric patients who have infections that are due to a specific bacteria (Vancomycin-Resistant Enterococcus)
- Trial name
- NCT00035854
- Testing
- Zyvox® / Linezolid
- Where
- 21 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pfizer
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients
This study is designed to find out whether HIV-positive patients whose immune systems have improved after receiving anti-HIV treatment should take azithromycin to prevent Mycobacterium avium complex (MAC) disease.
- Trial name
- NCT00000947
- Testing
- Azithromycin
- Where
- 19 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cystic Fibrosis
Antimicrobial Resistance in Cystic Fibrosis (CF)
People with cystic fibrosis (CF) often develop chronic pulmonary infections which are caused by a variety of organisms, the most predominant being Pseudomonas aeruginosa. Antibiotics are important in managing CF lung infections.
- Trial name
- NCT00360503
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
HELICOBACTER PYLORI INFECTIONS
Antibiotic Resistance of Helicobacter Pylori in Nanjing: A Cross-Sectional Study
This study aims to provide an updated analysis of the resistance patterns of H. pylori in the Nanjing region, with a focus on characterizing the current status of phenotypic and genotypic resistance to these six antimicrobial…
- Trial name
- NCT07455448
- Testing
- Antimicrobial susceptibility testing
- Where
- China
- Volunteers
- 7,227 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Escherichia Coli Infections
Detection of Biofilm Among Uropathogenic Escherichia Coli Clinical Isolates in Suez Canal University Hospitals
This descriptive cross-sectional study will beconducted in Suez Canal University Hospitals (SCUHs) in Ismailia, Egypt. The study aims to detect Escherichia coli biofilm producers to improve prognosis and treatment and reduce…
- Trial name
- NCT06252428
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- Suez Canal University
Malnutrition Severe, Antibiotic Resistance
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition
Children with severe malnutrition who are admitted sick to hospitals have a high mortality(death rate), usually because of infection.
- Conditions
- Malnutrition Severe, Antibiotic Resistance, Antibiotic Toxicity
- Trial name
- FLACSAM (NCT03174236)
- Testing
- Ceftriaxone, Benzyl penicillin, Metronidazole
- Where
- 8 sites in Kenya, Uganda
- Volunteers
- 2,000 people
- Sponsor
- University of Oxford
Sexually Transmitted Diseases, Bacterial, Antibiotic Resistant Infection
The Antibiotic Guardian Study- Clinical Evaluation of a Novel, Rapid Diagnostic for Gonorrhoea and Mycoplasma Infections.
Primary research question: Are novel molecular tests for rapid detection of Mycoplasma and Gonorrhoea infections and antimicrobial resistance sensitive and specific in symptomatic patients attending a sexual health clinic?…
- Trial name
- Guardian (NCT05391035)
- Where
- 2 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Acute Otitis Media
Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media
To evaluate the safety profile of amoxicillin-clavulanate potassium containing a reduced concentration of clavulanate potassium, 600 mg/21.5 mg/5 mL (a ratio of 28:1), administered at 90/3.2 mg/kg/day (formulation 1) or at…
- Trial name
- NCT02630992
- Testing
- Amoxicillin-Clavulanate potassium
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Nader Shaikh
HIV Infections, Tuberculosis
A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.
To determine the demographic, behavioral, clinical, and geographic risk factors associated with the occurrence of multidrug-resistant pulmonary tuberculosis (MDRTB).
- Trial name
- NCT00000796
- Testing
- Cycloserine, Ethionamide, Capreomycin sulfate
- Where
- 21 sites in United States
- Volunteers
- 525 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Antibiotic Resistance, Respiratory Tract Infections
CRP for Respiratory Diagnosis in Kyrgyz Pediatric Practice
Rationale: Overuse of antibiotics globally is leading to increasing rates of antibiotic resistance and may lead to a 'post-antibiotic' era.
- Conditions
- Antibiotic Resistance, Respiratory Tract Infections, Pediatric Infectious Disease, CRP
- Trial name
- COORDINATE (NCT05195866)
- Testing
- CRP POCT (C-reactive protein point of care test)
- Where
- Kyrgyzstan
- Volunteers
- 1,204 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Wounds and Injuries, War-Related Injuries
Wound Bacterial Microbiota and Their Antibiotic Resistance
The purpose of the study is to explore the microbiology in war-associated wounds of hospitalized patients from the Syrian armed conflict. Cultures collected from acute wounds with clinical signs of infection will be analyzed.
- Conditions
- Wounds and Injuries, War-Related Injuries, Wound Infection, Wounds, Penetrating
- Trial name
- NCT02744144
- Where
- Jordan
- Volunteers
- 457 people
- Sponsor
- Karolinska Institutet
Infant, Premature, Diseases
Probiotics On Resistant Bacteria Colonization In Preterm Receiving Antibiotics
In this study, the investigators investigated the effect of probiotic use on colonization of resistant microorganisms in newborn preterm infants receiving antibiotics.
- Trial name
- NCT02178267
- Testing
- Lactobacillus reuteri (biogai AB, Sweden)
- Volunteers
- 51 people
- Sponsor
- Baskent University
Antibiotic Resistant Infection
Antibiotic Resistance in Global Pediatric Oncology Centers
Antibiotic resistance is one of the major health threats facing global as well as domestic populations, however it is not well characterized in pediatric patients.
- Trial name
- NCT03721562
- Where
- 5 sites in United States, El Salvador and 2 more
- Volunteers
- 560 people
- Sponsor
- St. Jude Children's Research Hospital
Bacteriology
Dynamic of the Acquisition of Antibiotic Resistance in Integrons in Neonatology Newborns
Antibiotic resistance is a major public health issue as multiresistant bacteria (MRB) are increasing. Among the actions to control resistance, one is an interesting lead: to prevent the emergence of resistant bacteria by limiting…
- Trial name
- DAIR3N (NCT02434679)
- Where
- 5 sites in France
- Volunteers
- 278 people
- Sponsor
- University Hospital, Limoges
Sepsis, Neonatal Mortality
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care…
- Conditions
- Sepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric Infections
- Trial name
- CLEAN (NCT06824350)
- Testing
- chlorination for water disinfection and surface disinfection, infection prevention and control messaging
- Where
- 2 sites in United States, Kenya
- Volunteers
- 45,450 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Culture-proven Infection
Clinical Presentations, Microbiology, Antibiotic Resistance Patterns and Management Outcomes of Culture-proven Infection Among Adolescent and Adult in A Tertiary Hospital in Saudi Arabia
The characteristics of patients as well as microbiologic profile of culture-proven infection will be studies in conjunction with clinical outcome within 28-days
- Trial name
- NCT04395586
- Testing
- Culture
- Sponsor
- Aseer Central Hospital
Detection of Type VI Secretion System in K.Pneumoniae, Detection of Relation to Ab Resistance, Biofilm
Type VI Secretion System in Klebsiella Pneumoniae
Klebsiella pneumoniae (K. pneumoniae) is an important opportunistic pathogen contributing to nosocomial and antimicrobial-resistant infections. The increasing prevalence of infections caused by multidrug-resistant K.
- Trial name
- Klebsiella (NCT05516654)
- Testing
- Routine bacteriological cultures, Identification of the organism and antibiotic sensitivity will be done by VITEK II, Detection of biofilm formation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University
Drug Resistance, Microbial, Antimicrobial Stewardship
Gonorrhoea Resistance Assessment by Nucleic Acid Detection (GRANDII)
Three sexual health clinical services across Australia and their associated pathology testing laboratories are implementing a new management program for gonorrhoea infection.
- Conditions
- Drug Resistance, Microbial, Antimicrobial Stewardship, Gonorrhea
- Trial name
- GRANDII (NCT04268342)
- Testing
- Resistance guided treatment for gonorrhoea infection
- Where
- Australia
- Volunteers
- 1,626 people
- Sponsor
- The University of Queensland
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University