Clinical trials: Antimicrobial Photodynamic Therapy
Antimicrobial Photodynamic Therapy
The Effect of Antimicrobial Photodynamic Therapy on the Success of Root Canal Treatment
The decontamination of the root canal system from pathological microflora is essential for the success of endodontic treatment. Mechanical instrumentation and irrigation solutions, known as the chemomechanical process, are…
- Trial name
- NCT06634745
- Testing
- Standard Needle Irrigation (SNI), Passive Ultrasonic Irrigation (PUI, EndoActivator (EA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Dental Pulp Necroses, Tooth, Nonvital
Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Anterior Primary Teeth With Pulp Necrosis
This randomized controlled clinical trial evaluated the immediate reduction in intracanal microbial load and the short-term clinical and radiographic progression of anterior primary teeth with pulp necrosis after conventional…
- Trial name
- NCT02485210
- Testing
- Conventional Endodontic Treatment, Antimicrobial Photodynamic Therapy
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- University of Nove de Julho
Chromogenic Extrinsic Tooth Stains
Photodynamic Therapy for Preventing Recurrent Chromogenic Stains on Deciduous Teeth
Chromogenic extrinsic stains are common in children and frequently recur following conventional prophylaxis. Antimicrobial photodynamic therapy (aPDT) using methylene blue activated by red light has demonstrated antimicrobial…
- Trial name
- NCT07736339
- Testing
- Antimicrobial Photodynamic Therapy, Conventional Prophylaxis
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Photochemotherapy Reaction, Dental Pulp Necrosis
Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study
Microorganisms play a critical role in the etiology and pathogenesis of apical periodontitis. Enterococcus faecalis and Candida sp. are frequently associated with persistent infections.
- Conditions
- Photochemotherapy Reaction, Dental Pulp Necrosis, Polymerase Chain Reaction, Infection
- Trial name
- NCT03212729
- Testing
- ANTIMICROBIAL PHOTODYNAMIC THERAPY, Conventional endodontic treatment
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Dental Caries
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct Treatment of Deep Carious Lesions in Children
This project aims to evaluate the effect of antimicrobial photodynamic therapy (aPDT) in deep carious lesions. This study was approved by the Research Ethics Committee and was conducted on 53 patients between 3 and 12 years.
- Trial name
- NCT02908789
- Testing
- Antimicrobial photodynamic therapy (aPDT), Without Antimicrobial phothodynamic therapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Dental Caries
An in Vitro Evaluation of Antimicrobial Photodynamic Therapy on Deciduous Carious Dentin
Despite of the decline of dental caries, this disease is still common in polarized groups affecting children. Therefore, the aim of this randomized blind in vivo study was to compare the antimicrobial effect of two antimicrobial…
- Trial name
- NCT02479958
- Testing
- Rubber dam isolation, Tooth drying, Dentin wash with chlorhexidine 2%
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Photodynamic Therapy, Third Molar Extraction
The Effect of Photodynamic Therapy on Post-extraction Third Molar
The extraction of lower third molars is one of the most frequent procedures in oral surgery. For this reason, the extraction of these teeth generally requires a surgical approach involving the elevation of a mucoperiosteal flap…
- Conditions
- Photodynamic Therapy, Third Molar Extraction, Antimicrobial Photodynamic Therapy
- Trial name
- NCT06964178
- Testing
- Experimental: antimicrobial photodynamic therapy (aPDT) after extraction of third molar
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Caries
Antimicrobial Photodynamic Therapy as an Adjunct for Management of Deep Caries Lesions
Alternatively to conventional treatments, chemo-mechanical caries removal agents can be used. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT).
- Trial name
- NCT05236205
- Testing
- Caries removal with a lowspeed drill, Partial removal of carious tissue with the administration of Papacarie™, Partial removal of carious tissue with the administration of Papacarie™ and application of Bixa Orellana extract (20%)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Molar Incisor Hypomineralization
Antimicrobial Photodynamic Therapy on Teeth With Molar Incisor Hypomineralization
Molar Incisor Hypomineralization (MIH) is a change in the formation of dental enamel of systemic origin that affects at least one of the first four permanent molars and usually affects incisors.
- Trial name
- NCT03904641
- Testing
- aPDT, ART
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Hypomineralization Molar Incisor
Evaluation of Antimicrobial Photodynamic Therapy and Minimal Intervention Associated With Deproteinization in Permanent Teeth With Molar Incisor Hypomineralization
Introduction: Molar Incisor Hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT05443035
- Testing
- Antimicrobial PDT and Papacarie Deproteinization, Conventional caries treatment, Antimicrobial PDT and 5% NaOCl Deproteinization
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Periradicular Disease
Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy
The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.
- Trial name
- NCT02555488
- Testing
- diode laser, Methylene blue
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Health Care Associated Infection
Clinical Trial Evaluating Chlorine e6 Derivative-mediated Antimicrobial Photodynamic Therapy as a Treatment for Denture Stomatitis
Objective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS).
- Trial name
- NCT04532060
- Testing
- Nystatin, Antimicrobial Photodynamic Therapy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Periodontal Diseases
Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients
The aim of this study was to evaluate the effectiveness of antimicrobial photodynamic therapy as an adjuvant of scaling and root planning for treatment of periodontal disease in patients with Down's Syndrome.
- Trial name
- NCT02938988
- Testing
- Antimicrobial photodynamic therapy, Scaling and root planning, red laser
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo
Root Canal Disinfection
Estimate the Effect of aPDT on Root Canal Disinfection
The aim of this study is to compare the clinical effect of traditional root canal disinfection and aPDT on root canal disinfection. And provide the reference for clinical application and experience.
- Trial name
- NCT02929927
- Testing
- Rubber dam isolation, aPDT, 1% iodine tincture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Dental Plaque
Disclosing Agents as Photosensitizers in aPDT for Biofilm Control in Children
This randomized controlled clinical trial aims to evaluate the effectiveness of plaque disclosing agents used as photosensitizers in antimicrobial photodynamic therapy (aPDT) for the control of dental biofilm in children aged 3…
- Trial name
- NCT07539181
- Testing
- Mechanical Prophylaxis, aPDT with Erythrosine, aPDT with GC TriPlaque ID Gel
- Volunteers
- 72 people
- Sponsor
- University of Nove de Julho
Aggressive Periodontitis
Treatment of Aggressive Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
The treatment of aggressive periodontitis (AgP) represents a challenge for clinicians, because there are no standardized protocols for efficient control of the disease.
- Trial name
- NCT02049008
- Testing
- Photodynamic Therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Dental Caries
Effect of aPDT on Deep Caries in Permanent Tooth
The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium…
- Trial name
- NCT02929914
- Testing
- Local anesthesia and rubber dam isolation, Incomplete caries removal and microbiological samples collection, Dentin washed with sodium 0.9% saline
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University
Dental Caries in Children, Dental Plaque
Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases
The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can…
- Conditions
- Dental Caries in Children, Dental Plaque, Tooth Decay, Periodontitis
- Trial name
- LumoPrevent (NCT06286501)
- Testing
- Lumoral Treatment, Standard, personalized oral health care
- Where
- Finland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wellbeing Services County of Pirkanmaa
Dental Plaque, Tooth Discoloration
aPDT for the Remediation of Dental Black Stain
In today's society cosmetic dentistry plays an important role in social relationships and in important aspects of life such as job applications and recruitment processes.
- Trial name
- NCT03483376
- Testing
- Dental prophylaxis, Antimicrobial photodynamic therapy (aPDT)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University