Clinical trials: Antimicrobial Photodynamic Therapy
Burns, Wound Infection
Topical Methylene Blue-Photodynamic Therapy (MB-PDT) for Burn Wound Infection
Burn wound infections remain a major source of morbidity in patients with thermal injuries and contribute to delayed healing, graft loss, and prolonged hospitalization.
- Trial name
- NCT07494773
- Testing
- Methylene Blue, Blue Light Illumination
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma
COVID-19 Respiratory Infection, SARS-CoV-2 Acute Respiratory Disease
Photodynamic Therapy for COVID-19 Prevention
This is a single-center open-label study to evaluate antimicrobial photodynamic therapy (aPDT) for upper airway decolonization in patients presenting with SARS-CoV-2 positive antigen test with mild or no symptoms of COVID-19.
- Trial name
- NCT05184205
- Testing
- Nasal Photodisinfection
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Ondine Biomedical Inc.
Dental Caries in Children, Dental Plaque
Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases
The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can…
- Conditions
- Dental Caries in Children, Dental Plaque, Tooth Decay, Periodontitis
- Trial name
- LumoPrevent (NCT06286501)
- Testing
- Lumoral Treatment, Standard, personalized oral health care
- Where
- Finland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wellbeing Services County of Pirkanmaa
Photodynamic Therapy (PDT), Periodontitis
Photodynamic Therapy in Non-surgical Periodontal Therapy
Non-surgical periodontal therapy is a widely adopted procedure for the treatment of periodontitis, particularly in its moderate to severe stages.
- Conditions
- Photodynamic Therapy (PDT), Periodontitis, Antimicrobial Photodynamic Therapy
- Trial name
- aPDT-PD (NCT07080762)
- Testing
- antimicrobial photodynamic therapy (aPDT) after non-surgical therapy
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Periodontal Diseases
Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients
The aim of this study was to evaluate the effectiveness of antimicrobial photodynamic therapy as an adjuvant of scaling and root planning for treatment of periodontal disease in patients with Down's Syndrome.
- Trial name
- NCT02938988
- Testing
- Antimicrobial photodynamic therapy, Scaling and root planning, red laser
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo
Dental Plaque, Pus Collection
Regular Antibacterial Photodynamic Therapy on Oral Hygiene in Elderly Residents
Around 40 people will participate in the study. The study participants will be recruited from service homes in the City of Helsinki. The subjects will be randomized into two groups.
- Conditions
- Dental Plaque, Pus Collection, Oral Disease, Dryness Oral
- Trial name
- NCT05853679
- Testing
- Lumoral Treatment, Standard oral hygiene instructions according to the Finnish Dental Association
- Where
- Finland
- Volunteers
- 31 people
- Sponsor
- Koite Health Oy
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling
Chronic periodontitis is an infectious disease resulting in inflammation of the teeth support structures, progressive periodontal attachment loss and bone loss.
- Trial name
- NCT03498404
- Testing
- Photodynamic Therapy, scaling and root planing
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontal Diseases, Oral Halitosis
The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered Toothbrush in Older Individuals With Periodontitis and Mild Cognitive Impairment.
Objective: To compare three different oral hygiene regimens regarding plaque index (PI), bleeding on probing (BOP), the number of deepened periodontal pockets ≥4 mm (PPD), oral halitosis, and changes in oral health-related…
- Trial name
- e-DENT II (NCT07166224)
- Testing
- Oral-B Powered toothbrush, Dual-Light aPDT Treatment - Lumoral
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Blekinge Institute of Technology
Root Canal Infection
Toluidine Blue-Based Photodynamic Therapy for Antibacterial Activity and Postoperative Pain
This clinical study aims to evaluate the antimicrobial effectiveness and postoperative pain outcomes of photodynamic therapy using Toluidine Blue O as an adjunct to conventional root canal treatment in patients diagnosed with…
- Trial name
- NCT07266233
- Testing
- Toluidine Blue O (0.1 mg/mL), 630-nm LED Light Device, Photodynamic Therapy (PDT)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ataturk University
Efficacy of Preoperative Microbial Reduction in the Nasal Cavity Using Antimicrobial Photodynamic Therapy (aPDT)
Preoperative Microbial Reduction of the Nasal Cavity With Antimicrobial Photodynamic Therapy (aPDT).
The goal of this clinical trial is to investigate the preoperative microbial reduction of the nasal cavity using Photodynamic Therapy (aPDT) in adult patients undergoing surgical intervention at the Department for…
- Trial name
- NCT06570252
- Testing
- activated Light Source (aPDT), non activated Light Source (Control)
- Volunteers
- 208 people
- Sponsor
- University of Zurich
DENT IMPLANTS, LASER
Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
The purpose of this study is to compare clinical outcomes (change in bleeding sites (BOP) and probing depth reduction (PPD) after mechanical debridement of implant surfaces at sites exhibiting plaque induced inflammation with or…
- Trial name
- NCT04187053
- Testing
- Conventional mechanical therapy, Saline, Methylene Blue
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hypomineralization Molar Incisor
Evaluation of Antimicrobial Photodynamic Therapy and Minimal Intervention Associated With Deproteinization in Permanent Teeth With Molar Incisor Hypomineralization
Introduction: Molar Incisor Hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT05443035
- Testing
- Antimicrobial PDT and Papacarie Deproteinization, Conventional caries treatment, Antimicrobial PDT and 5% NaOCl Deproteinization
- Where
- Brazil
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Periodontitis
Single Session Of Antimicrobial Photodynamic Therapy Using Indocyanine Green
In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. Commercially available photodynamic therapy for periodontal diseases utilizes methylene blue as a…
- Trial name
- NCT02043340
- Testing
- indocyanine green, LASER, Scaling and Root Planing
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Surgical Site Infections, Infections
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada
This is a Phase 4 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Infections, Surgical Wound Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT07189858)
- Testing
- Nasal antimicrobial photodisinfection therapy
- Where
- 4 sites in Canada
- Volunteers
- 401 people
- Sponsor
- Ondine Biomedical Inc.
Chronic Periodontitis, Smoking
Adjunct Photodynamic Therapy in Chronic Periodontitis Among Cigarette-smokers.
This study evaluates the efficacy of scaling and root planing with and without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of chronic periodontitis (CP) among cigarette-smokers and never-smokers.
- Trial name
- NCT03308019
- Testing
- Photodynamic therapy, Scaling and root planing (SRP)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- King Saud University
Chromogenic Extrinsic Tooth Stains
Photodynamic Therapy for Preventing Recurrent Chromogenic Stains on Deciduous Teeth
Chromogenic extrinsic stains are common in children and frequently recur following conventional prophylaxis. Antimicrobial photodynamic therapy (aPDT) using methylene blue activated by red light has demonstrated antimicrobial…
- Trial name
- NCT07736339
- Testing
- Antimicrobial Photodynamic Therapy, Conventional Prophylaxis
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Molar Incisor Hypomineralization
Antimicrobial Photodynamic Therapy on Teeth With Molar Incisor Hypomineralization
Molar Incisor Hypomineralization (MIH) is a change in the formation of dental enamel of systemic origin that affects at least one of the first four permanent molars and usually affects incisors.
- Trial name
- NCT03904641
- Testing
- aPDT, ART
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Caries
An in Vitro Evaluation of Antimicrobial Photodynamic Therapy on Deciduous Carious Dentin
Despite of the decline of dental caries, this disease is still common in polarized groups affecting children. Therefore, the aim of this randomized blind in vivo study was to compare the antimicrobial effect of two antimicrobial…
- Trial name
- NCT02479958
- Testing
- Rubber dam isolation, Tooth drying, Dentin wash with chlorhexidine 2%
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Sinusitis
Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis
The purpose of this study is to determine whether the use of light and a topically applied photosensitizer can relieve symptoms and clinically improve patients with chronic rhinosinusitis.
- Trial name
- NCT01854619
- Testing
- Photodisinfection (antimicrobial photodynamic therapy, aPDT), Saline irrigation
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Ondine Biomedical Inc.
Peri Implant Mucositis, Dental Implant Rehabilitation
Home-Use Dual-Light Antibacterial Photodynamic Therapy for Peri-Implant Mucositis in Full-Arch Implant Prostheses
The goal of this clinical trial is to learn whether a home-use light device helps control gum inflammation around dental implants in adults who have a full set of fixed teeth attached to implants.
- Conditions
- Peri Implant Mucositis, Dental Implant Rehabilitation, Prosthesis and Implant Dentistry, Implant Supported Prosthesis
- Trial name
- NCT07763431
- Testing
- Dual-light antibacterial photodynamic therapy, Supportive peri-implant care
- Volunteers
- 24 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City