Clinical trials: Apnea (Central and Obstructive)
Obstructive Sleep Apnea, Sleep Disorder
Validation of Pediatric Sleep Questionnaire on a Swedish Cohort
This study is aimed to validate the questionnaire called Pediatric Sleep Questionnaire on a Swedish cohort of children from 18 months to 15 years old with obstructive sleep disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Sleep Disorders in Children, Obstructive Sleep Apnea of Child
- Trial name
- NCT06367400
- Testing
- Pediatric Sleep Questionnaire
- Where
- Sweden
- Volunteers
- 520 people
- Sponsor
- Uppsala University
Central And Obstructive Apnoeas In Infants
Improved Discrimination Of Central And Obstructive Apnoeas In Infants
Referral of infants to the respiratory sleep disorders breathing team with apnoeas [pauses in their breathing] and apparent life-threatening episodes are frequent.
- Trial name
- NCT04234074
- Testing
- Volusense paediatric monitoring device
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Hypotonia, Muscle, Obstructive Sleep Apnea
Long-term Evaluation of Nasopharyngeal Airway in Hypotonia
This research is studying the long term use of a nasal airway device (self-supporting nasopharyngeal airway; "ssNPA") in children with hypotonic upper airway obstruction to learn about its effectiveness and tolerability as a…
- Conditions
- Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
- Trial name
- NCT06614582
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and Malocclusion
Multi-disciplinary Diagnosis and Treatment Process and Evaluation System for Children With Sleep Disordered Breathing and Malocclusion
The aim of this study is to compare the efficacy and safety of drug therapy, tonsillar adenoidectomy only, orthodontic treatment only and tonsillar adenoidectomy plus orthodontic treatment in children with obstructive sleep apnea…
- Trial name
- NCT03451318
- Testing
- Mometasone Furoate Nasal Spray, tonsillar adenoidectomy, Maxillary expander plus Twin-Block
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Stomotological Hospital
Apnea of Prematurity, Desaturation of Blood
Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%.
- Conditions
- Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing
- Trial name
- NCT03695900
- Testing
- Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Miami
Asthma, Bronchial, Bronchial Asthma
Sleep Apnea in Asthmatic Children and Teenagers
Asthma and sleep apnea are both respiratory diseases and one can worsen the other. Those who suffer from asthma have a higher risk of sleep apnea and sleep apnea can make the asthma more difficult to control.
- Conditions
- Asthma, Bronchial, Bronchial Asthma, Apnea, Sleep, Sleep Apnea, Mixed Central and Obstructive
- Trial name
- NCT03034447
- Testing
- Questionnaire, Lung Function Test, Home Sleep Study
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of São Paulo
Stroke, Transient Ischemic Attack
DOC Utility: Screening of Depression, Obstructive Sleep Apnea and Cognitive Impairment
The primary objective of this study is to determine whether baseline DOC screening can add to clinical and demographic data to predict the occurrence of a composite negative outcome (any of: recurrent stroke, myocardial…
- Conditions
- Stroke, Transient Ischemic Attack, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02363114
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- Dr. Richard H. Swartz
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis
European Home Mechanical Ventilation Registry
The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Muscular Dystrophies
- Trial name
- EHMVR (NCT02315339)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- ResMed
Sleep Disordered Breathing, Obstructive Sleep Apnea
Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients
The purpose of this study is to assess the prevalence and morbidity rates of sleep disordered breathing in cardiac surgery patients.
- Conditions
- Sleep Disordered Breathing, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- NCT00922168
- Where
- 2 sites in United States
- Volunteers
- 146 people
- Sponsor
- Cleveland Medical Devices Inc
Obstructive Sleep Apnea, Hypoventilation
The IPAd Study: Exploring the Association Between Insomnia and Positive Airway Pressure Adherence in Children
Sleep-disordered breathing (SDB) is prevalent in children and adolescents and untreated SDB impacts key indicators of physical and psychosocial health.
- Conditions
- Obstructive Sleep Apnea, Hypoventilation, Central Sleep Apnea
- Trial name
- IPAd (NCT05949164)
- Testing
- Insomnia
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- The Hospital for Sick Children
Apnea, Sleep Apnea Syndromes
Oropharyngeal Exercises and Post-Stroke Obstructive Sleep Apnea
This study evaluates the feasibility and effectiveness of an oropharyngeal exercise (O-PE) regimen in treating post-stroke obstructive sleep apnea, as an alternative therapy to continuous positive airway pressure (CPAP).
- Conditions
- Apnea, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Stroke
- Trial name
- NCT04212260
- Testing
- Oropharyngeal exercises
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea
Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study
The goal of this clinical trial is to learn whether a newer sleep-testing device gives results that closely match the standard overnight sleep study, in children and adolescents ages 6-18 who are being evaluated for possible…
- Trial name
- NCT07851402
- Testing
- WatchPAT 400
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Sleep Disorder; Breathing-Related, Central Apnea
Transcutaneous CO2 Monitoring at Home for Children With Neuromuscular Disease
There is an unmet demand for the evaluation of nocturnal hypoventilation in children with NMD. An ambulatory screening tool that can reliably facilitate timely diagnosis and treatment in these children would be invaluable.
- Conditions
- Sleep Disorder; Breathing-Related, Central Apnea, Neuromuscular Diseases, Obstructive Sleep Apnea
- Trial name
- NCT03478566
- Testing
- Transcutaneous CO2 monitoring
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- The Hospital for Sick Children
Obesity, Obstructive Sleep Apnea
Does Treating Obstructive Sleep Apnea in Obese Canadian Youth Improve Blood Sugar Control?
To determine whether, in obese children with moderate-severe Obstructive Sleep Apnea who are prescribed Positive Airway Pressure(PAP) therapy, increased hours of PAP usage per night over a one-year period is associated with a…
- Trial name
- IMPACT Obesity (NCT01116375)
- Where
- 4 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Katz, Sherri Lynne, M.D.
Obstructive Sleep Apnea, Sleep Apnea, Obstructive
Orthognathic Surgery and Obstructive Sleep Apnea Assessed by Mandibular Jaw Movement Monitoring (SUNRISE-ORTHO)
Orthognathic surgery changes the skeletal framework of the upper airway, but its functional effect on sleep-disordered breathing remains poorly documented, particularly with respect to respiratory effort.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Obstructive, Dentofacial Deformities
- Trial name
- SUNRISE-ORTHO (NCT07910461)
- Testing
- Orthognathic surgery (BSSO with or without Le Fort I osteotomy), Sunrise mandibular jaw movement monitoring, Facial multidetector CT in natural head position
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- CHR Sambre et Meuse Site Meuse
Transient Ischemic Attack, Stroke
Post-stroke Triage "DOC": Simple Screening for Depression, Obstructive Sleep Apnea and Cognitive Impairment
The purpose of this study is to determine whether simple, evidence-based clinical screening be quickly and feasibly implemented (>85% of patients in an average of <6 minutes) in large-volume urgent transient ischemic attack…
- Conditions
- Transient Ischemic Attack, Stroke, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02007265
- Where
- Canada
- Volunteers
- 1,504 people
- Sponsor
- Sunnybrook Health Sciences Centre
Epilepsy, Obstructive Sleep Apnea
Investigation of Sleep Quality and Prevalence of Sleep-disordered Breathing in Children and Young People With Epilepsy
Obstructive sleep apnoea (OSA) is a condition that affects around one in 20 children. In children with OSA, repeated episodes of airway obstruction can severely disturb and fragment sleep, leading to subsequent cognitive and…
- Trial name
- NCT03103841
- Testing
- Sleep studies [Polysomnography]
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Sleep Disordered Breathing (SDB), Sleep Apnea
Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study
Sleep disordered breathing (SDB) is one of the most common sleep disorders, including obstructive sleep apnea (OSA), central sleep apnea (CSA), sleep-related hypoventilation, hypoxemia, etc., with OSA being the most prevalent.
- Conditions
- Sleep Disordered Breathing (SDB), Sleep Apnea, Cardiometabolic Diseases, Multimorbidity
- Trial name
- NCT06755840
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Obesity, Obstructive Sleep Apnea (Moderate to Severe)
Heated Humidified High Flow Nasal Cannula Oxygen in Obstructive Sleep Apnea in Adolescents
The research study is being done to test heated humidified high-flow air (HHF), as a treatment for OSA.
- Conditions
- Obesity, Obstructive Sleep Apnea (Moderate to Severe), Central Sleep Apnea
- Trial name
- NCT05354401
- Testing
- HHF
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children