Clinical trials: Augmentation
Obesity
The Effects of Methylphenidate on Energy Intake and Energy Expenditure
The Problem: Obesity is one of the leading causes of chronic disease and death. The efficacy of diet and exercise to sustain weight loss over the long term is weak.
- Trial name
- MPH (NCT02754258)
- Testing
- MPH
- Where
- 2 sites in Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Severely Atrophic Jaw
Determination of Bone Volume Changes of the Cranial Bone-augmented Jaw: A Feasibility Study
The investigators aim to determine the level of total bone volume remodeling at 6, 24 and 36 months post-surgery in patients who underwent immediate prosthetic rehabilitation through a cranial bone-grafted maxilla in combination…
- Trial name
- VOLCRAN (NCT02810184)
- Testing
- cone-beam computed tomography (CBCT)
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- AZ Sint-Jan AV
Deproteinized Bovine Bone Mineral Graft Dimensional Changes
Long-term DBBM Dimensional Changes in Sinus Grafting
This study aims to evaluate graft volumetric changes and stability up to 12 years after lateral sinus floor elevation with deproteinized bovine bone mineral (DBBM) as a filling material.
- Trial name
- NCT07635472
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Saint-Joseph University
Bone Grafting, Sinus Lifting
Outcomes of Different Bone Graft Combinations for Maxillary Sinus Augmentation Procedure
This study investigates the outcomes of a surgical procedure that is performed to increase bone support at a future implant site on the upper back jaw area.
- Trial name
- MSA-BGC (NCT07512011)
- Testing
- Bone grafting on both sides
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ohio State University
Metabolic Syndrome, Obesity
Effect of Low Carbohydrate Versus Low Fat Diet in the Treatment of Dyslipidemia in Obese Children With Metabolic Syndrome
Two-arm, parallel design with children between the ages of 10 - 18 with obesity and metabolic syndrome randomized (15 per group) to reduced-carbohydrate diet or a reduced-fat diet for 8 weeks.
- Conditions
- Metabolic Syndrome, Obesity, Dyslipidemias
- Trial name
- NCT03937960
- Testing
- Carbohydrate restricted group, Standard low fat diet
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Multiple Myeloma
Health-Related Quality of Life (QOL), Physical and Respiratory Function in Patients With Myeloma Affecting the Spine
The purpose of this study is to create a prospective database of patients with myeloma affecting the spine. This database will define changes in health-related quality of life over time, and the effect of incident fractures and…
- Trial name
- NCT01006070
- Testing
- kyphoplasty
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Rotator Cuff Tear, Rotator Cuff Tears
Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff
This is a clinical investigation study. It will verify the long-term safety and performance of the Pitch-Patch when implanted to reinforce partially repairable rotator cuff tears and used as described by the manufacturer's…
- Conditions
- Rotator Cuff Tear, Rotator Cuff Tears, Rotator Cuff Tears of the Shoulder, Rotator Cuff Injuries
- Trial name
- NCT05906004
- Testing
- Pitch-Patch
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Xiros Ltd
Obsessive Compulsive Disorder (OCD)
NAC for Treatment-Resistant OCD and Other Related Disorders
This is a randomized, double-blind, placebo-controlled study investigating N-acetylcysteine (NAC) as an augmentation therapy for individuals with treatment-resistant obsessive-compulsive disorder (TR-OCD), studied within a…
- Trial name
- NCT06956157
- Testing
- N-Acetylcysteine Tablets
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Atrophy of Edentulous Alveolar Ridge, Alveolar Ridge Augmentation
Evaluation of Ridge Dimensional Changes After Immediate Implantation and Efficacy of This Procedure
1. Evaluation of dimensional changes in alveolar ridge following immediate implantation compared to delayed implantation 2. evaluation of the effect of gap dimensions between socket walls and dental implant in implant stability
- Trial name
- NCT01399775
- Testing
- immediate implantation, Delayed implantation
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Maxillary Sinus
PRF Versus Advanced PRF in Sinus Augmentation
In the present study the main hypothesis , Advanced PRF will improve the bone quality and quantity in sinus augmentation
- Trial name
- NCT05134753
- Testing
- Advanced PRF, Control
- Volunteers
- 32 people
- Sponsor
- Cairo University
Meniscal Tear
This is a Study to Verify if Marrow Venting Procedure Can Improve Meniscal Suture Healing
Meniscal suture represents the current surgical practice, and marrow venting is a low risk procedure. Bone venting may be able to improve the outcome of meniscal repair, allowing the patient a better recovery.
- Trial name
- NCT05053646
- Testing
- Meniscal repair, Marrow venting procedure
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Christian Candrian
Leukemia
Immuno-Augmentation With GM-CSF of Pneumococcal Vaccine in Chronic Lymphocytic Leukemia Patients
The goal of this clinical research study is to see if Leukine(R) (sargramostim) improves the effectiveness of the pneumococcal vaccine, a medicine used to prevent pneumococcal pneumonia, in patients with chronic lymphocytic…
- Trial name
- NCT00323557
- Testing
- Sargramostim (GM-CSF), Pneumococcal Vaccine
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- M.D. Anderson Cancer Center
Regeneration of Alveolar Tissue After Maxillary Sinus Floor Augmentation
Smart Scaffolds, Stronger Smiles Smarter Healing: AI-Boosted Multiphasic Scaffold Design for PDL Regeneration
The periodontal ligament is vital for tooth support, and its loss, frequently resulting from periodontitis, trauma, or endodontic lesions, presents a significant clinical challenge; global cases of severe periodontitis increased…
- Trial name
- NCT07845006
- Testing
- AI algorithms generated a 3D multiphasic, graded lattice structure
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Misr University for Science and Technology
Obsessive-compulsive Disorder
D-Cycloserine Augmentation of Therapy for Pediatric Obsessive-Compulsive Disorder
Cognitive-behavioral therapy (CBT) has proven efficacy for treatment of pediatric obsessive-compulsive disorder (OCD). Yet, CBT does not help all children and those who benefit often remain symptomatic upon treatment completion.
- Trial name
- NCT00864123
- Testing
- Cognitive-behavioral therapy, D-cycloserine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Atrophied Anterior Maxillary Ridges
GBR With Ptfe With Bovine Bone With and Without Autogenous
Ridge Augmentation in Atrophic Anterior Maxillary Ridges with a Titanium Reinforced Polytetraflouroethelene Membrane and Anorganic Bovine Bone-Derived Mineral in intervention group and Anorganic Bovine Bone-Derived Mineralwith…
- Trial name
- NCT03628157
- Testing
- Geistlich Bio-Oss® bovine bone alone
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adrenoleukodystrophy, Batten Disease
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
The primary objective of the study is to determine the safety and feasibility of intrathecal administration of DUOC-01 in patients who are undergoing standard treatment with umbilical cord blood transplant (UCBT) for inborn…
- Conditions
- Adrenoleukodystrophy, Batten Disease, Mucopolysaccharidosis II, Leukodystrophy, Globoid Cell
- Trial name
- DUOC-01 (NCT02254863)
- Testing
- DUOC-01
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Joanne Kurtzberg, MD
Dental Implants, Dental Implants , Osseointegration , Marginal Bone Loss , Implant Stability
Periosteal Sutures Versus Titanium Tacks for Guided Bone Re-generation in the Aesthetic Zone: a Pilot Randomized Controlled Trial
This randomized controlled clinical study, titled "Periosteal sutures for fixation of composite bone substitutes in guided bone regeneration: a randomized controlled clinical study," is being conducted at the Dental Unit of…
- Conditions
- Dental Implants, Dental Implants , Osseointegration , Marginal Bone Loss , Implant Stability, Maxillary Alveolar Reconstruction
- Trial name
- NCT07330232
- Testing
- Periosteal mattress sutures for graft/membrane stabilization in guided bone regeneration Titanium tacks for graft/membrane stabilization in guided bone regeneration
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Treatment Resistant Psychosis, Psychosis
Stratification and Treatment in Early Psychosis Study -ASSIST
The purpose of this trial is: To investigate whether the response to clozapine treatment can be enhanced by adding cannabidiol (CBD), compared to placebo, in treatment resistant psychosis patients.
- Trial name
- STEP-ASSIST (NCT07326124)
- Testing
- CBD 100 mg/mL Oral Solution, Placeb
- Where
- 15 sites in Germany, Greece and 6 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Rotator Cuff Tears
MRI Evaluation of Integrity Implant for Rotator Cuff Tears
The goal of this observational study is to evaluate the effectiveness and safety of the Integrity bio-inductive implant in treating partial and full thickness rotator cuff tears.
- Trial name
- NCT06353893
- Testing
- Anika Integrity Implant System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for Orthopaedic Research and Education
First Episode Psychosis
Efficacy of Treating First Episode Psychosis With Folic Acid,B12 and B6 in Addition to Antipsychotic Medication
The purpose of this study is to determine whether Vitamin B12,B6 and Folic Acid are effective with antipsychotic medication in the treatment of First Episode Psychosis.The B-complex Vitamins' homocysteine lowering properties may…
- Trial name
- NCT00202280
- Testing
- Folic Acid 5mg, Vitamin B12 0.4mg and B6 50mg
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Melbourne Health