Clinical trials: Augmentation
Incisional Hernia
Standardization of Laparoscopic Hernia Repair
Incisional hernias are one of the most frequent complications in abdominal surgery. Laparoscopic repair is widely used but even not standardized.
- Trial name
- LIPOM (NCT02089958)
- Testing
- Laparoscopic incisional hernia repair
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Klinikum Fulda
Depression
Folate Augmentation of Treatment - Evaluation for Depression: a Randomised Controlled Trial
To determine whether giving folic acid to people with depression will help their antidepressants work better. If folate does help antidepressants to work better, then it will provide a safe, simple and cheap way of improving the…
- Trial name
- FolATED (NCT00514410)
- Testing
- Folic Acid
- Where
- 3 sites in United Kingdom
- Volunteers
- 730 people
- Sponsor
- Bangor University
Rotator Cuff Tear
Decellularized Human Placental Extracellular Matrix Tissue for Rotator Cuff Repair Augmentation
The rotator cuff is a set of muscles and tendons that help move the shoulder. Tears in the rotator cuff are common, particularly as people age. Consequently, rotator cuff repair surgeries are common, as well.
- Trial name
- ECMRCR (NCT07027735)
- Testing
- Rotator Cuff Repair with Allograft Patch, Rotator Cuff Repair with No Augmentation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Columbia University
Peri-Implantational Loss, Surgical Wound
Strip Graft w/ Xenogeneic Matrix vs Free Gingival Graft for the Augmentation of Peri-implant Keratinized Mucosa
The primary objective of this study is to compare changes in peri-implant keratinized mucosa (PIKM) following the application of apically repositioned flap (ARF) using a combination of a Strip graft and a Xenogeneic matrix, or…
- Conditions
- Peri-Implantational Loss, Surgical Wound, Healing Surgical Wounds, Thin-gingiva
- Trial name
- NCT06261268
- Testing
- Strip graft with Mucograft, Free gingival graft
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Cystectomy, Segmental Growing of Alveolar Tissue
Study of Collagen Membrane in Guided Bone Regeneration
The main purpose of this study is to investigate the efficacy of Hypro-Sorb® F, a bilayered bioabsorbable membrane in inducing bone regeneration in different dental procedures requiring GBR.
- Conditions
- Cystectomy, Segmental Growing of Alveolar Tissue, Sinus Lift, Root Amputation and Apicoectomy
- Trial name
- GBR (NCT00454038)
- Testing
- HYPRO SORB F
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Major Depressive Disorder
A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatine
The purpose of this study was to investigate the efficacy and safety of antidepressant augmentation with agomelatine in the treatment of patients with depression who did not demonstrate satisfying response to selective serotonin…
- Trial name
- NCT04589143
- Testing
- Agomelatine
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Central South University
Soft Tissue Defect
Evaluation of Geistlich Fibro-Gide® in Comparison to CTG for the Treatment Around Implants
This double blind, randomized, parallel study evaluates the non-inferiority of Geistlich Fibro-Gide® in comparison to connective tissue graft for soft tissue volume augmentation around dental implants
- Trial name
- NCT04703738
- Testing
- Soft tissue flap + Connective Tissue Graft, Soft tissue flap + Geistlich Fibro-Gide®
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Geistlich Pharma AG
Smoking Cessation
Progesterone Augmentation of Nicotine Replacement Therapy Study
This will be a double-blind, placebo-controlled, pilot, randomized clinical trial. A total of 50 women who smoke and have regular menstrual cycles will be randomized to either progesterone (200 mgs BID) + Transdermal Nicotine…
- Trial name
- PANS (NCT02685072)
- Testing
- Progesterone (200 mgs BID)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Yale University
Lip Augmentation
Safety and Effectiveness of Restylane® Kysse for Lip Augmentation in Chinese Subjects
Open-label, phase IV, post-marketing study to evaluate aesthetic improvement in Chinese subjects after treatment with Restylane Kysse.
- Trial name
- NCT05342753
- Testing
- Restylane Kysse
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Galderma R&D
Peri-implantitis, Soft Tissue Augmentation at Dental Implants
Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis
This study aims to increase the width and thickness of peri-implant keratinized mucosa (KM) by transferring a properly dimensioned free gingival graft (FGG) from the palatal donor site and to evaluate its effect as an adjunctive…
- Trial name
- NCT07471386
- Testing
- Submucosal debridman + saline irrigation, Free gingival graft surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Bone Atrophy
Bone Augmentation Using Calvarial Versus Iliac Crest Bone Blocks.
This study aims to evaluate and compare the quantity of the radiographic horizontal bone gain of severely deficient complete maxillary ridges reconstructed by bone block harvest from the iliac crest versus the calvarial bones
- Trial name
- NCT06434441
- Testing
- Autogenous bone augmentation
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Beni-Suef University
Major Depressive Disorder
Iloperidone Augmentation of SSRIs for Patients With Major Depressive Disorder With Residual Anger and Irritability
Iloperidone is an atypical antipsychotic drug, FDA-approved for the acute treatment of schizophrenia in adults in 2009 (Marino et al., 2010); moreover, some of its pharmacological features seem to be very promising in treating…
- Trial name
- NCT01464229
- Testing
- Iloperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Maurizio Fava, MD
Mid Face Volume Deficit
A Study to Assess Adverse Events and Change in Disease Activity of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation in Adult Participants
The cumulative effect of aging and environmental exposures (ie, ultraviolet, infrared, and visible light radiation and pollution) leads to wrinkles, discoloration, laxity, and roughness of sun exposed skin.
- Trial name
- NCT05452070
- Testing
- HArmonyCa Lidocaine Injectable Gel
- Where
- 12 sites in Canada, Spain and 1 more
- Volunteers
- 171 people
- Sponsor
- Allergan
Major Depressive Disorder
VA Augmentation and Switching Treatments for Improving Depression Outcomes
The overall purpose is to determine research based 'next-steps' for outpatients with major depressive disorder who have not had satisfactory outcomes to standard 'first-step' treatments.
- Trial name
- VAST-D (NCT01421342)
- Testing
- Switching: Bupropion-SR, Augmenting: Antidepressant + Bupropion-SR, Augmenting: Antidepressant + Aripiprazole
- Where
- 35 sites in United States
- Volunteers
- 1,522 people
- Sponsor
- VA Office of Research and Development
Lip Augmentation
New Dermal Filler for Lip Augmentation
To demonstrate non-inferiority of Kysse versus a control in lip fullness augmentation
- Trial name
- NCT03320824
- Testing
- New Dermal Filler, Device: FDA Approved Dermal Filler
- Where
- 14 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Atrophy of Breast
Efficacy and Safety Study of EVERA to Augment Small Breast
Expected Total Number of Subjects Level of significance, alfa 0.05 Power 0.80 Mean difference between two treatments is assumed 35 Standard Deviation is assumed 35. Follow-up loss is assumed 20% N=34(each group:17)
- Trial name
- NCT02009137
- Testing
- EVERA, ESTES
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Depression
Thrive Care: Internet CBT for Depression
This project will study the effectiveness of computerized cognitive behavioral therapy (CBT) in reducing depression symptoms. The design is a two-arm randomized controlled trial comparing (i) control arm, which is treatment as…
- Trial name
- NCT03079895
- Testing
- Thrive
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Kaiser Permanente
Peri-implant Mucositis
Impact of Keratinized Mucosa Augmentation on Treatment Outcomes of Peri-implant Mucositis
This study aims to observe the effects of keratinized mucosa width on peri-implant tissues by evaluating clinical and biochemical parameters.
- Trial name
- NCT06305000
- Testing
- Non-surgical treatment, Free gingival graft
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Biruni University
Lip Augmentation
Safety and Effectiveness of Juvederm(R) Ultra XC Injectable Gel for Lip Augmentation
The purpose of this study is to demonstrate the safety and effectiveness of Juvederm(R) Ultra XC Injectable Gel for lip augmentation
- Trial name
- NCT01197495
- Testing
- hyaluronic acid gel
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Allergan
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