Clinical trials: Biliary Condition
Congenital Biliary Dilatation, Choledochal Cyst
The Application of Digital Intelligent Diagnostic and Therapeutic Technology in Biliary Dilation Diagnosis
This research discusses the clinical application value of augmented reality navigation technology combined with three-dimensional visualization technology in improving surgical safety and promoting the development of precision…
- Trial name
- DIIBD (NCT06418490)
- Testing
- Three-dimensional visualization technology
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Choledocholithiasis With Cholecystitis
Early Versus Delayed Laparoscopic Cholecystectomy Following ERCP in Concomitant Gallstones and Common Bile Duct Stones
The present study aimed to compare early and delayed laparoscopic cholecystectomy after ERCP for CBDs and gallstones.
- Trial name
- NCT04475796
- Testing
- Laparoscopic cholecystectomy
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Kafrelsheikh University
Cholestasis
Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis
The purpose of this research study is to see if giving Omegaven (an intravenous fat emulsion containing fish oil) instead of the current lipid emulsion, which contains fat derived from soybeans, as part of your child's…
- Trial name
- NCT01173159
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Alagille Syndrome
A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment
This study will collect information from patients with ALGS who are using odevixibat in their daily lives. Odevixibat is a medication that helps patients with ALGS, a rare disease that affects the liver and causes itching.
- Trial name
- NCT07585097
- Where
- 14 sites in France, Italy
- Volunteers
- 30 people
- Sponsor
- Ipsen
Acute Calculous Cholecystitis, Gallbladder Empyema
Role of Intra-Operative Aspiration in Distended GB in LC
Laparoscopic cholecystectomy (LC) is a standard procedure for gallstones and the standard surgical approach for acute calcular cholecystitis, superseding open cholecystectomy for gallbladder (GB) pathologies.
- Conditions
- Acute Calculous Cholecystitis, Gallbladder Empyema, Gallbladder Mucocele
- Trial name
- NCT07378410
- Testing
- Laparoscopic needle
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Aswan University
Alagille Syndrome
Safety and Efficacy Study of LUM001 in the Treatment of Cholestatic Liver Disease in Patients With Alagille Syndrome
The study is a randomized, double-blind, placebo-controlled study to evaluate the safety and tolerability of LUM001. Efficacy will be assessed by evaluating the effect of LUM001 versus placebo on the biochemical markers and…
- Trial name
- IMAGO (NCT01903460)
- Testing
- LUM001
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Determine the benefit of oral vancomycin therapy for Primary Sclerosing Cholangitis.
- Trial name
- PSC (NCT01802073)
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Biliary Atresia, Cholangitis
Definition for Biliary Atresia Associated Cholangitis After Surgery
Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients.
- Trial name
- NCT05464303
- Testing
- Intravenous Antibodies
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Children's Hospital
Biliary Atresia
Part II: Granulocyte-Colony Stimulating Factor Adjunct Therapy for Biliary Atresia
The Investigators propose to test the hypothesis that GCSF enhances the clinical outcome of biliary atresia in a multi-institutional Phase 2 trial to prospectively evaluate the safety and efficacy of GCSF in each of the 2 groups…
- Trial name
- BA_GCSF2b (NCT04373941)
- Testing
- Filgrastim
- Where
- 4 sites in United States, Pakistan and 1 more
- Volunteers
- 400 people
- Sponsor
- Holterman, Ai-Xuan, M.D.
Biliary Atresia
Safety Study of Intravenous Immunoglobulin (IVIG) Post-Portoenterostomy in Infants With Biliary Atresia
The Children Liver Disease Research and Education Network (ChiLDREN) is conducting a clinical trial to determine the feasibility, acceptability, tolerability and safety profile of IVIG treatment administered to infants after…
- Trial name
- PRIME (NCT01854827)
- Testing
- Intravenous immunoglobulin (IVIG)
- Where
- 7 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Parenteral Nutrition, Necrotizing Enterocolitis
Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain.
- Conditions
- Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392730
- Testing
- Remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Biliary Atresia, Intrahepatic Cholestases
Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)
A prospective observational study in infants with biliary atresia and controls to determine whether the composition of the intestinal microbiome is specific for biliary atresia will be conducted.
- Conditions
- Biliary Atresia, Intrahepatic Cholestases, Normal Controls
- Trial name
- BA (NCT03890536)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Nutrition Disorder, Infant, Biliary Atresia
Nutritional Intervention for Biliary Atresia
Infants with biliary atresia (Biliary atresia, BA) have an increased risk of malnutrition due to insufficient dietary intake to maintain normal growth, impaired intestinal absorption, increased metabolic rate, and damage to some…
- Trial name
- NCT06764082
- Testing
- high MCT formula, normal oral intake of the traditional formula
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji Hospital
Living Donor Liver Transplantation
Transcystic Versus Transanastomotic Tube Drainage in Right Lobe LDLT
To evaluate the safety and effectiveness of the use of transcystic biliary drainage tube (not transanastomotic) in comparison to the usual transanastomotic biliary drainage tube.
- Trial name
- NCT01907750
- Testing
- biliary drainage tube
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Mansoura University
Cholelithiasis, Biliary Dyskinesia
Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Cholecystectomy
Prospective randomized trial of single incision versus standard 4 port laparoscopic cholecystectomy. Hypothesis is that the operative time will be longer with single incision.
- Trial name
- SILS (NCT00981604)
- Testing
- SILS, Standard Laparoscopic Cholecystectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cholecystitis
Predictive Factors of Drain Insertion After Laparoscopic Cholecystectomy: A Cohort Study
This study looks at when surgical drains are truly needed after laparoscopic gallbladder removal (laparoscopic cholecystectomy).
- Trial name
- NCT07195643
- Testing
- Drain
- Where
- Iraq
- Volunteers
- 559 people
- Sponsor
- University of Baghdad
Cholestatic Liver Disease (Except ALGS, PFIC, PBC and PSC)
Evaluation of Maralixibat in Pruritus Associated With General Cholestatic Liver Disease (EXPAND)
The purpose of this study is to determine whether the investigational treatment (maralixibat) is safe and effective in pediatric and adult participants who have cholestatic liver disease with pruritus that has been refractory to…
- Trial name
- NCT06553768
- Testing
- Maralixibat
- Where
- 23 sites in United States, Brazil and 8 more
- Volunteers
- 90 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Cholestasis, Total Parenteral Nutrition-induced Cholestasis
Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury
The purpose of this study is to provide intravenous omega-3 fatty acids and monitor tolerance in subjects with prolonged parenteral nutrition dependence and parenteral nutrition-associated cholestasis through expanded access.
- Trial name
- NCT02780193
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Rush University Medical Center
Gallbladder Diseases
Cholecystoduodenal Fistula With and Without Gallstone Ileus
Observative and descriptive study of 10 patients, which were diagnosed with a Cholecystoduodenal fistula, All electronic medical records were retrospectively reviewed.
- Trial name
- NCT03888976
- Testing
- Cholecystectomy
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Tecnologico de Monterrey