Clinical trials: Biological Therapy
Metastatic Melanoma
Vaccine Biotherapy of Cancer: Autologous Tumor Cells and Dendritic Cells
This protocol was conducted as a single institution trial at Hoag Cancer Center, Hoag Hospital, Newport Beach, California. It was a single-arm phase II trial in which patients with metastatic melanoma received subcutaneous (s.c.)…
- Trial name
- DCVaccineMel (NCT00948480)
- Testing
- Autologous tumor cells plus dendritic cells, GM-CSF
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Rubinstein-Taybi Syndrome
Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic Trial
An exploratory phase 2 therapeutic trial in children from 6 to 21, RTS carriers, randomized to be treated either with sodium valproate with the usual pediatric dosage (30 mg/kg/j), or by placebo for one year.
- Trial name
- RUBIVAL (NCT01619644)
- Testing
- sodium valproate
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Bordeaux
Diagnosis and Treatment of Depression
A Study of Diagnosis and Treatment of Depression Based on Biological Evidence of Dopamine Reward Pathway
This study will recruit depressed patients unresponsive to selective serotonin reuptake inhibitor antidepressant treatment, first-degree relatives (parents or siblings) of depressed patients, schizophrenia, Parkinson's disease…
- Trial name
- NCT03148509
- Testing
- risperidone, aripiprazole, bupropion
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking University
Attention-deficit/Hyperactivity Disorder
Attention-deficit/Hyperactivity Disorder Translational Center for Identifying Biomarkers
The purpose of this study was to identify genetic, brain morphologic, and environmental biomarkers that contribute to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD).
- Trial name
- NCT02623114
- Testing
- methylphenidate, atomoxetine
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Seoul National University Childrens Hospital
Breast Neoplasms, Breast Cancer
Assessment of Breast Cancer Response to Neoadjuvant Anthracycline-based Chemotherapy by FDG-PET and Molecular Markers
A correlation between early changes in the tumor maximum standardized uptake value (SUVmax) on FDG-PET after one or two cycles of neoadjuvant chemotherapy (NAC) and the pathological response after 6 to 8 cycles has been…
- Trial name
- NCT02600442
- Testing
- non interventional study
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Similarities and Differences of Biological Therapies for Severe Asthma.
This is an ambispective multicenter longitudinal observational study to evaluate the efficacy and safety profile of biological therapies in patients diagnosed with severe asthma in real life conditions.
- Trial name
- NCT04665141
- Testing
- Mepolizumab, Omalizumab, Reslizumab
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Retinoblastoma, Cancer Survivor
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and…
- Conditions
- Retinoblastoma, Cancer Survivor, Biological Sibling, Intraocular Retinoblastoma
- Trial name
- RIVERBOAT (NCT03932786)
- Testing
- Biospecimen collection, Vision assessment, Questionnaire administration
- Where
- 11 sites in United States, Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Crohn's Disease
A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.
- Trial name
- NCT03104413
- Testing
- risankizumab SC, risankizumab IV
- Where
- 403 sites in United States, Argentina and 41 more
- Volunteers
- 618 people
- Sponsor
- AbbVie
Leukemia, Neutropenia
Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00002658
- Testing
- filgrastim, amsacrine, cyclophosphamide
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Medical Research Council
Neuroblastoma, Rhabdomyosarcoma
Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)
Methodology: Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma
- Trial name
- MICCHADO (NCT03496402)
- Testing
- Sampling on blood, bone marrow and cerebrospinal fluid
- Where
- 30 sites in France
- Volunteers
- 600 people
- Sponsor
- Institut Curie
Crohn's Disease (CD)
Biologics and Paediatric Enteral Nutrition in Crohn's Disease Study
Crohn's disease (CD) is a chronic, incurable condition associated with gut inflammation. Two important treatments currently used to manage CD are special drug injections (biologics) or a liquid-only diet using specialised…
- Trial name
- BIOPIC-Kids (NCT07522528)
- Testing
- enteral nutrition
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Multiple Myeloma and Plasma Cell Neoplasm
Combination Chemo, Peripheral Stem Cell Transplant, Biological Therapy, Pamidronate and Thalidomide for Multiple Myeloma
RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and…
- Trial name
- NCT00004088
- Testing
- filgrastim, recombinant interferon alfa, busulfan
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- City of Hope Medical Center
Crohn Disease
Biologics and Partial Enteral Nutrition Study
Crohn's disease (CD) is a chronic, incurable condition associated with inflammation in the gut lining. It causes diarrhoea, severe abdominal pain, poor nutrition and adversely affects the quality of life of sufferers.
- Trial name
- BIOPIC (NCT04859088)
- Testing
- Partial Enteral Nutrition
- Where
- 4 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Crohn's Disease, Ulcerative Colitis
Disease Course in an IBD Cohort in the Era of Biological Treatment
The aim of the study is to do a 7-year follow-up of a consecutive inception cohort of 562 adults and children diagnosed and registered with inflammatory bowel disease in 2003-04 in order to evaluate the consequences of biological…
- Trial name
- NCT01468090
- Where
- 2 sites in Denmark
- Volunteers
- 192 people
- Sponsor
- Hvidovre University Hospital
Effect of Drug
Efficacy of Biological Therapy in Pediatric Inflammatory Bowel Disease
Compare efficacy of different biologicals in induction of remission including clinical, laboratory and histopathological remission.
- Trial name
- NCT06742606
- Testing
- Group 1 of patients will receive Adalimumab while Group 1 will receive ustekinumab
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hypereosinophilic Syndrome, Chronic Eosinophilic Leukemia
Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes
The study was performed to assess: 1) clinical activity of Imatinib in patients with HES, CEL and CIH; 2) correlation between Imatinib activity and specific disease subtype; 3) long-term outcome of HES, CEL and CIH patients…
- Conditions
- Hypereosinophilic Syndrome, Chronic Eosinophilic Leukemia, Chronic Idiopathic Hypereosinophilia
- Trial name
- NILG-HES1-03 (NCT00787384)
- Testing
- Imatinib
- Where
- 4 sites in Italy
- Volunteers
- 25 people
- Sponsor
- Northern Italy Leukemia Group
Congenital Ichthyosis
Scientific Substantiation and Assessment of the Effectiveness of Pathogenetic Methods of Therapy for Congenital Ichthyosis in Children
This is an experimental non-randomized clinical study aimed at expanding the indications for the use of biological drugs with the aim of using them for the pathogenetic therapy of children with congenital ichthyosis.
- Trial name
- NCT04996485
- Testing
- Secukinumab Injection, Ustekinumab Injection, Dupilumab Injection
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Participation Level Below 55% and/or Special Needs
Effects of Hirudotherapy, Phytotherapy, and Forest Therapy in Adults With Reduced Work Capacity or Special Needs
This interventional study will evaluate the effects of three complementary and alternative health care services-forest therapy, phytotherapy, and hirudotherapy-in individuals with a participation level below 55% and/or special…
- Trial name
- CAM-HPMT (NCT07709221)
- Testing
- Phytotherapy, Forest Therapy, Hirudotherapy
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Klaipėda University
Stomach Cancer, Stomach Cancer Recurrent
TIL Therapy Combined With Pembrolizumab for Advanced or Metastatic Refractory Stomach and Esophageal Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with advanced or metastatic refractory stomach…
- Conditions
- Stomach Cancer, Stomach Cancer Recurrent, Stomach Cancer, Adenocarcinoma, Esophageal Cancer
- Trial name
- BAH250 (NCT06532799)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamid, Fludarabine
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Essen Biotech
Colorectal Cancer, Colon Cancer
Biological Tumor Infiltrating Lymphocytes Therapy With Immunotherapy for Colon and Rectum Cancer
This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) and Aldesleukin (interleukin-2, IL-2) immunotherapy in patients with…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectum Cancer
- Trial name
- BAH248 (NCT06530303)
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech