Clinical trials: Birth Control
Plasmodium Falciparum Malaria
Superiority of ArTiMist Versus Quinine in Children With Severe Malaria
The purpose of this study is to demonstrate that ArTiMist (sublingual artemether spray) is better than intravenous quinine in reducing parasite counts by >= 90% within 24 hours after the start of treatment in children with severe…
- Trial name
- NCT01258049
- Testing
- Artemether Sublingual Spray, Quinine
- Where
- 3 sites in Burkina Faso, Ghana and 1 more
- Volunteers
- 151 people
- Sponsor
- Proto Pharma Ltd
Growth Hormone Therapy, Infant, Very Low Birth Weight
Somatropin Therapy In Children Born Preterm But Appropriate For Gestational Age
Safety and efficacy of Somatropin will be evaluated in short children born with a list weight below 1500 g and that did not catch up to normal height at the age of 4.
- Trial name
- AGA (NCT00174460)
- Testing
- Somatropin, Control Arm
- Where
- 8 sites in Germany
- Volunteers
- 33 people
- Sponsor
- Pfizer
Respiratory Control in Premature Infants
Prematurity-Related Ventilatory Control
The purpose of this research study is to improve our understanding of unstable breathing and heart blood flow patterns seen in premature infants.
- Trial name
- PreVent (NCT03464396)
- Testing
- Bedside Physiology study, Carotid Body Function Test, Room Air Challenge
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Washington University School of Medicine
Pregnancy, Malnutrition in Pregnancy
Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi)
Acute malnutrition in pregnancy is a risk factor for adverse outcomes in mothers and their unborn children. Undernutrition during pregnancy can result in maternal complications such as life-threatening hemorrhage and hypertensive…
- Conditions
- Pregnancy, Malnutrition in Pregnancy, Nutrition Disorders, Stunting
- Trial name
- NCT03079388
- Testing
- Ready-to-use-supplementary food, Corn-soy-blend, Monthly intermittent preventive treatment of malaria during pregnancy (IPTp)
- Where
- Sierra Leone
- Volunteers
- 1,489 people
- Sponsor
- Washington University School of Medicine
Induction of Labor Affected Fetus / Newborn
An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt
Induction of labour (where labour is started artificially) is traditionally carried out with a range of different drugs or by surgery (rupturing the membranes or 'waters').
- Trial name
- SOLVE (NCT03001661)
- Testing
- Dilapan-S, Dinoprostone
- Where
- United Kingdom
- Volunteers
- 674 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Contraception, Family Characteristics
Evaluation of a Mass Media Family Planning Campaign on the Uptake of Contraceptive Methods in Burkina Faso
In this experiment, the investigators will study the effect of a mass media family planning campaign on contraception related behavior.
- Conditions
- Contraception, Family Characteristics, Family Size, Desired
- Trial name
- NCT02714686
- Testing
- Radio Mass Media Family Planning Campaign
- Where
- Burkina Faso
- Volunteers
- 7,515 people, healthy volunteers welcome
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Unintended Pregnancy, Contraception
Contraceptive Choice Center
The Contraceptive Choice Center will use an innovative-model of contraceptive care which was developed as a part of the Contraceptive CHOICE Project (CHOICE).
- Conditions
- Unintended Pregnancy, Contraception, Family Planning
- Trial name
- C3 (NCT02633631)
- Where
- United States
- Volunteers
- 2,664 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Patent Ductus Arteriosus, Preterm Infant
Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus
The purpose of the present study is to determine whether treatment of hemodynamically significant patent ductus arteriosus with a combined therapy of intravenous Ibuprofen and oral acetaminophen has higher success rate in closing…
- Conditions
- Patent Ductus Arteriosus, Preterm Infant, Bronchopulmonary Dysplasia
- Trial name
- NCT03701074
- Testing
- Ibuprofen and acetaminophen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of South Alabama
Contraceptive Usage
Effectiveness of Counseling on Use of Postpartum Family Planning.
Family planning (FP) is the most supported, reasonable public health service to prevent both maternal and newborn mortality and decrease the risk of adverse maternal, perinatal, and infant outcomes.
- Trial name
- NCT05079100
- Testing
- postpartum contraception method counselling
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Type 1 Diabetes
Simplified Meal Approach Using Hybrid Closed-loop Insulin Delivery in Youth and Young Adults With Type 1 Diabetes
The purpose of the study is to examine whether a simplified meal approach (as compared to exact carbohydrate counting) can alleviate the need of carbohydrate counting without worsening postprandial control in youth and young…
- Trial name
- SMASH (NCT05481034)
- Testing
- SMA bolus option, Exactly estimated carbohydrate content bolus option
- Where
- 2 sites in Switzerland
- Volunteers
- 46 people
- Sponsor
- Lia Bally
Low Birth Weight
Efficacy of Continuous Skin to Skin Care (Technique Kangaroo: TK) After Birth for Low Birth Weight (LBW) Infants and Their Mothers in Developing Countries
The purpose of this study is to examine the efficacy of Technique Kangourou (TK) between low birth weight (LBW) infants and their mothers started as soon as possible within 24 hours after birth in developing country.
- Trial name
- EtudeTK (NCT00531492)
- Testing
- TK as soon as possible within 24 hours after birth, Conventional care
- Where
- Madagascar
- Volunteers
- 73 people
- Sponsor
- Foundation for Advanced Studies on International Development
Periodontal Diseases
Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern
the research highlight the effectiveness of probiotics as adjuncts to SRP in the treatment of periodontitis stage III grade C molar-incisor pattern
- Trial name
- RCT (NCT06253988)
- Testing
- Probiotic Formula
- Where
- Egypt
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Contraception, Contraception Behavior
SihatMand Khandaan Healthy Families for Pakistan
The SMK project's primary goal is to improve the status of SRH of women and adolescents within those targeted areas which feature inadequate progress on existing SRH indicators.
- Conditions
- Contraception, Contraception Behavior, Reproductive Behavior, Maternal Behavior
- Trial name
- SMK (NCT06125470)
- Testing
- Uptake of quality Reproductive health and Family planning products, information and Services, Capacity building of facility based and community based healthcare providers (public and private sector) on FP /SRH, Adolescent Engagement
- Where
- 2 sites in Pakistan
- Volunteers
- 236,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Neonatal Respiratory Distress, Very Low Birth Weight Infant
Evaluation of the Impact of SpO2 Averaging Time on Performance of an Automatic FiO2 Control System: a Randomized Study
The aim of the study is to determine the preferred oximeter averaging setting during automated control of FiO2 (A-FiO2) in infants receiving respiratory support and supplemental oxygen.
- Trial name
- NCT05274386
- Testing
- Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 4to6 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 10 s, Fabian ventilator with PRICO system (Acutronic Medical Systems AG, Hirzel, Switzerland); SpO2 averaging time set to 16 s
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- Czech Technical University in Prague
Respiratory Distress Syndrome, Newborn
Antepartum Betamethasone Treatment for Prevention of Respiratory Distress in Infants Born by Elective Cesarean Section
This is a randomized, multicenter, double blind, placebo controlled trial of betamethasone versus a placebo given prior to the mothers at term and near term gestation (>34 and <40 weeks of gestation) who are scheduled to undergo…
- Trial name
- NCT00139256
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Emory University
Hemodynamic Instability
Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit
Low blood pressure is a common problem in the premature newborn and can affect over 30% of all Extremely Low Gestational Age Neonates (ELGAN) babies delivered less than 28 weeks completed.
- Trial name
- MUSE (NCT03841929)
- Testing
- Hemodynamic report
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Testing a Conversion Factor for a More Rapidly Acting Insulin in an Automated Insulin Delivery System Among Adolescents With T1D
A randomized controlled trial of Control-IQ, assessing glycemic control (time-in-range 70-180 mg/dL) for Lyumjev insulin (in which the insulin settings have been determined using an experimental conversion factor) as compared to…
- Trial name
- Lpad Lyumjev (NCT06948760)
- Testing
- Control-IQ insulin pump with Lyumjev insulin, Control-IQ insulin pump with Humalog or Novolog
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mark D. DeBoer, MD, MSc., MCR
Contraception
Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial
This is a pilot study to determine the feasibility for a randomized controlled trial of two forms of intrauterine contraception: the Levonorgestrel intrauterine system (LNG-IUS) and the Copper T 380A.
- Trial name
- MINT (NCT00653159)
- Testing
- Levonorgestrel-releasing intrauterine device (LNG-IUS), Copper T380A intrauterine device (CuT380A)
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Asthma
Evaluation of the Prevalence of Asthma in a Cohort of Children Born After IVF (Aged 11-15) Compared With a Control Group
Assisted Reproduction Technologies (ART) are increasingly being used worldwide as a result of fertility decline likely caused by changes in both environment and social behaviour.
- Trial name
- EMCeFIV (NCT02636179)
- Testing
- Comparative epidemiological survey
- Where
- France
- Volunteers
- 1,792 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Pregnancy, Sexually Transmitted Diseases
Development and Testing of a Clinic-Based Intervention to Increase Dual Protection Against Unintended Pregnancy and Sexually Transmitted Diseases (STDs) Among High Risk Female Teens
This trial will evaluate a multi-component, clinic-based intervention aimed at increasing dual protection strategy selection and adherence among young African American females at an urban family planning clinic.
- Trial name
- 2Gether (NCT02291224)
- Testing
- Interactive multimedia platform, Intervention arm counseling, Standard of care counseling
- Where
- United States
- Volunteers
- 709 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
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