Clinical trials: Bleeding Disorder
Thrombotic Microangiopathy, Hemolytic Uremic Syndrome
International Registry and Biorepository for TMA(Thrombotic Microangiopathy)
This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy
- Conditions
- Thrombotic Microangiopathy, Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura
- Trial name
- NCT00593229
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Hemophilia A
Study to Learn More About the Safety of Drug Jivi Over a Long Period of Time in Previously Treated Patients With Hemophilia A (Bleeding Disorder Resulting From a Lack of FVIII) Who Are Receiving Jivi Regularly at Their Treating Doctors to Prevent Bleeding
In this observational study researchers want to learn more about the safety of drug Jivi over a long period of time. Jivi (generic name: Damoctocog alfa pegol) is an approved blood clotting Factor VIII (FVIII) medication for the…
- Trial name
- HA-SAFE (NCT04461639)
- Testing
- Damoctocog alfa pegol (Jivi, BAY94-9027)
- Where
- 6 sites in Austria, Germany and 4 more
- Volunteers
- 62 people
- Sponsor
- Bayer
Premature Infants, Bronchopulmonary Dysplasia
Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)
This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term…
- Conditions
- Premature Infants, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Neurodevelopmental Outcomes
- Trial name
- OptiSTART (NCT05849077)
- Testing
- Sat75, Sat50
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Texas Southwestern Medical Center
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage
Prospective evaluation of patients with subarachnoid hemorrhage (SAH) will be done by computed tomography angiography (CTA) and perfusion imaging (CTP) for any correlation between degree of vasospasm and perfusion deficit as well…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Delayed Cerebral Ischemia
- Trial name
- NCT03214705
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy
The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhage
- Trial name
- NSR-GENE (NCT05361070)
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of California, San Francisco
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Intraventricular Hemorrhage, Autoregulation
Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage
Annually, almost 5,000 extremely low birth weight (9 ounces to about 2 lbs) infants born in the US survive with severe bleeding in the brain (intraventricular hemorrhage); this devastating complication of prematurity is…
- Trial name
- PhysDis (NCT00665769)
- Testing
- Hypercapnia, Normocapnia
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Baylor College of Medicine
Abnormal Uterine Bleeding, Unspecified, Uterine Bleeding Heavy
Treatment of Unacceptable Bleeding Patterns in ETG Implant Users With an Oral Contraceptive
This double-blinded, placebo-controlled, randomized trial will compare the effects of the use of a combined oral contraceptive pill to a placebo pill for women who are experiencing irregular and/or heavy bleeding associated with…
- Trial name
- ROBI (NCT01963403)
- Testing
- EE 30mcg/LNG 150mcg
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of California, Davis
Cesarean Delivery
The Effectiveness of a Care Bundle to Prevent Postpartum Hemorrhage After Cesarean Delivery
Delays in the detection or inconsistent use of effective interventions of postpartum hemorrhage can result in complications or death.
- Trial name
- RE-TEAM (NCT06684080)
- Testing
- A care bundle
- Volunteers
- 52,000 people
- Sponsor
- Dunjin Chen
Intracranial Hemorrhages, Mesenchymal Stem Cells
Follow-Up Study of Safety of Pneumostem® in Premature Infants With Intraventricular Hemorrhage
This is a follow-up study of the open label, single-center, phase I clinical trial to evaluate the safety of Pneumostem® in premature infants with Intraventricular hemorrhage.
- Conditions
- Intracranial Hemorrhages, Mesenchymal Stem Cells, Newborn Infant
- Trial name
- NCT02673788
- Testing
- observation without intervention in this follow up study
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Samsung Medical Center
Hemophilia A
A Study to Test a Medicine (Fitusiran) for Preventing Bleeds in People With Severe Hemophilia Who Previously Received Preventive Treatment With Emicizumab
This is an exploratory, single group, Phase 4, study to assess treatment with fitusiran prophylaxis after switching from emicizumab prophylaxis.
- Trial name
- NCT06145373
- Testing
- Fitusiran (SAR439774), Clotting factor concentrates (CFC) or bypassing agents (BPA), Antithrombin concentrate (ATIIIC)
- Where
- 3 sites in United States, Taiwan
- Volunteers
- 20 people
- Sponsor
- Sanofi
Hemophilia A
A Study of ADVATE in People With Hemophilia A in India
The main aim of this study is to learn more about side effects of Advate when given as standard treatment to people with hemophilia A who have already been treated.
- Trial name
- NCT04985682
- Testing
- ADVATE
- Where
- 5 sites in India
- Volunteers
- 50 people
- Sponsor
- Baxalta now part of Shire
Immune Thrombocytopenia
Extension Study of Herombopag for Pediatric Patients With Chronic Immune Thrombocytopenia
The main purpose of this extended study is to enable subjects who are currently receiving the PartB experimental drug in the HR-TPO-ITP-III-PED clinical trial .To continue receiving the experimental drug after the completion of…
- Trial name
- NCT05685420
- Testing
- Herombopag
- Volunteers
- 117 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Factor X Deficiency
A Study Investigating Treatment Factor X in People With Factor X Deficiency
The main objective of the study is to assess the pharmacokinetics of FACTOR X after a single dose of 25IU/kg. The secondary objectives of the study are to assess efficacy and safety of FACTOR X in the treatment of bleeding…
- Trial name
- NCT00930176
- Testing
- Human Coagulation FACTOR X
- Where
- 14 sites in United States, Germany and 3 more
- Volunteers
- 16 people
- Sponsor
- Bio Products Laboratory
Acquired Bleeding Disorder, Acquired Haemophilia
Observational Study on the Use of NovoSeven® for Haemostatic Treatment of Bleeding Episodes in Patients With Acquired Haemophilia
This study is conducted in Europe. The aim of this prospective, observational study are to describe the different clinical practice and detailed haemostatic management of activated recombinant human factor VII (NovoSeven®) in…
- Trial name
- ACQUI-7 (NCT01285089)
- Testing
- activated recombinant human factor VII
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Novo Nordisk A/S
Factor XIII Deficiency
A Study of the Use of Factor XIII Concentrate in Patients With Inherited FXIII Deficiency
Congenital deficiency of Factor XIII is an extremely rare hereditary disorder associated with potentially life-threatening bleeding.
- Trial name
- NCT00883090
- Testing
- FXIII Concentrate (Human)
- Where
- 6 sites in United States, Spain
- Volunteers
- 15 people
- Sponsor
- CSL Behring
Wiskott-Aldrich Syndrome (WAS)
Gene Therapy for Wiskott-Aldrich Syndrome
This is phase I/II protocol to evaluate the safety and efficacy of WAS gene transfer into hematopoietic stem/progenitor cells for the treatment of Wiskott Aldrich Syndrome.
- Trial name
- TIGET-WAS (NCT01515462)
- Testing
- TLT003
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione Telethon
Haemophilia A
An Open Study to Investigate the Safety and Efficacy of Optivate® in Haemophilia A Patients Undergoing Surgery.
The main objective of the study is to investigate the safety and efficacy of Optivate®, administered in appropriate dosage to present bleeding and achieve haemostasis in patients with Haemophilia A undergoing surgery.
- Trial name
- NCT02250482
- Testing
- Optivate® (Human Coagulation Factor VIII)
- Where
- 8 sites in Poland, United Kingdom
- Sponsor
- Bio Products Laboratory
Postpartum Hemorrhage, Pregnancy
RCT of Misoprostol for Postpartum Hemorrhage in India
Death rates for pregnant women in rural India are approximately forty-five times higher than in the United States. Bleeding after the birth of a child and underlying anemia are the primary causes of mothers' deaths and sickness…
- Trial name
- NCT00097123
- Testing
- Misoprostol
- Where
- India
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Phenprocoumon for the first…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947959
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Standard of care
- Where
- Germany
- Volunteers
- 665,533 people
- Sponsor
- Bayer
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