Clinical trials: Bowel Dysfunction
Crohn Disease
Advanced Non-Invasive Diagnostics in Inflammatory Bowel Disease
The purpose of this study is to determine whether Non-invasive endoscopic procedures (pillcam colon capsule endoscopy, PCCE) and non-ionizing radiological modalities (MR enterocolonography, MREC and ultrasound, US) - offer a…
- Trial name
- ANDI (NCT03134586)
- Testing
- Diagnostic imaging
- Where
- 3 sites in Denmark
- Volunteers
- 153 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Appendicitis
Non Absorbable Clips vs Endoloops in Laproscopic Appendicectomy
a) Compare between Nonabsorbable Polymeric Clips and Endoloop ligatures regarding: 1. technical difficulties. 2. operation time. 3. cost effectiveness. 4. postoperative complications. 5. inpatient stay.
- Trial name
- NCT04094480
- Testing
- polymeric non absorbable clips, endoloops
- Volunteers
- 40 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases (IBD)
Epidemiological Evaluation Of Chronic Kidney Disease In Pediatric Patients With Inflammatory Bowel Disease
This multicenter observational cross-sectional study aims to evaluate the prevalence of chronic kidney disease (CKD) in pediatric patients with inflammatory bowel disease (IBD) and to compare it with a control group without IBD.
- Trial name
- KIBD (NCT07670988)
- Testing
- Clinical and Laboratory Data Collection
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Colorectal Cancer
Real World Study of Regorafenib Versus Fruquintinib in Colorectal Cancer
This is an observational, ambispective cohort study. The aim is to compare the efficacy and safety of regorafenib versus fruquintinib conducted in China.
- Trial name
- NCT04431791
- Testing
- Regorafenib, Fruquintinib
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Peking University
Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies
Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral Deficiency
Dysimmune and specially hepatic immuno-pathological processes are frequent in patients with PIDs (primary immune deficiencies), particularly but not exclusively in patients with humoral defects.
- Conditions
- Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies, Combined Immunodeficiency (CID), Severe Combined Immunodeficiency (SCID)
- Trial name
- EVAH (NCT06659588)
- Testing
- Plasma, urine and stool collection
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crohn's Disease, Ulcerative Colitis
To Evaluate the Safety and Efficacy of Remsima™ in Patients With Crohn's Disease (CD) or Ulcerative Colitis (UC)
An observational, prospective cohort study to evaluate the safety and efficacy of Remsima™ in patients with Crohn's disease (CD) or Ulcerative Colitis (UC)
- Trial name
- NCT02326155
- Volunteers
- 470 people
- Sponsor
- Celltrion
Celiac Disease, Ovarian Failure
Can Celiac Disease Affect Ovarian Function in Adolescent?
This case-control multicentre trial was performed from January 1, 2017, to May 31, 2018, in University of Health Sciences Bakirkoy Dr. Sadi Konuk Training and Research Hospital and Hitit University Hospital.
- Trial name
- NCT04024449
- Testing
- Group A
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Diarrhea, Dysentery (Bloody Diarrhea)
Solar Disinfection of Drinking Water
SODISWATER is a European Union funded health impact assessment study investigating the effect of sunlight to inactivate microbial pathogens in drinking water.
- Trial name
- SODISWATER (NCT01082107)
- Testing
- Solar disinfection in transparent containers (plastic bottles)
- Where
- South Africa
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Council for Scientific and Industrial Research, South Africa
Irritable Bowel Syndrome
Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome
The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome.
- Trial name
- NCT01268709
- Testing
- Doxepin, Nortriptyline
- Where
- Iran
- Sponsor
- Qom University of Medical Sciences
Crohn's Disease
Top-down Infliximab Study in Kids With Crohn's Disease
The purpose of this study is to determine whether a top-down treatment approach, prescribing infliximab (IFX) and azathioprine (AZA) at diagnose, yields better outcome in comparison to the usual step-up treatment approach…
- Trial name
- TISKids (NCT02517684)
- Testing
- Infliximab, Prednisolone, Exclusive enteral nutrition
- Where
- 13 sites in Belgium, Finland and 1 more
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Crohn's Disease
Salvage Therapy With High/Low Methotrexate for Loss of Response to Infliximab Dose Escalation
The goal of the present study is to evaluate if addition of methotrexate can restore remission after loss of response to infliximab after dose escalation.
- Trial name
- NCT02269358
- Testing
- METHOTREXATE
- Where
- Israel
- Volunteers
- 22 people
- Sponsor
- Prof. Arie Levine
To Report the Rare Occurrence of Meckel's Diverticulum
The Uncommon Complications of Meckel's Diverticulum
Acas series study was conducted on emergency acute abdomen patients who finally confirmed intraoperatively as Meckel's diverticulum with different complications.
- Trial name
- MD (NCT05793385)
- Testing
- operative intervention
- Where
- Ethiopia
- Volunteers
- 4 people
- Sponsor
- Haramaya Unversity
Ulcerative Colitis, Crohn's Disease
Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate
Iron deficiency anaemia is common in inflammatory bowel disease (IBD), affecting at least 20% patients at any one time. Hepcidin, a recently described anti-microbial peptide synthesized by the liver, is a key regulator of iron…
- Trial name
- NCT01991314
- Testing
- Ferrous sulphate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Queen Mary University of London
Cryptosporidiosis
Treatment of Cryptosporidiosis
Background: 1. Burden: Cryptosporidiosis among the top 10 causes of diarrhea in the 1st year of life in low and middle-income countries (LMICs), with an estimated total of 48,000 annual deaths and accounting for 4.2 million…
- Trial name
- NCT04103216
- Testing
- Nitazoxanide with Lactobacillus Reuteri DSM 17938, Nitazoxanide
- Where
- Bangladesh
- Volunteers
- 64 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Breast Cancer, Colo-rectal Cancer
Cancer Mortality Affected by the Choice of Anesthetic Drugs?
Knowledge gap: Does the choice of anaesthetic affect outcome for cancer surgery? Aim: To retrospectively examine possible associations (Cox Multiple Regression) between survival from breast-, colorectal-, or skin cancer and the…
- Conditions
- Breast Cancer, Colo-rectal Cancer, Skin Cancer
- Trial name
- NCT01418326
- Where
- Sweden
- Volunteers
- 3,284 people
- Sponsor
- Enlund
Shigella Infection
Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants
The goal of this phase 1/2a, randomized, observer-blind, age-descending, dose-finding trial is to evaluate the safety and immunogenicity of a quadrivalent synthetic oligosaccharide-based Shigella vaccine (adjuvanted IP-QSV) in…
- Trial name
- NCT07666750
- Testing
- 30μg IP-QSV, 10μg IP-QSV, 2μg IP-QSV
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Intraventricular Hemorrhage, Sepsis
Placental Transfusion Project for Preterm Infants
The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants.
- Conditions
- Intraventricular Hemorrhage, Sepsis, Necrotizing Enterocolitis
- Trial name
- NCT02400697
- Testing
- <30 wks gestation or 1500 grams
- Where
- United States
- Volunteers
- 2,856 people
- Sponsor
- Indiana University
Hemorrhoids
A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids
The purpose of this study is to compare the therapeutic effect and safety of compound carraghenates cream with Mayinglong musk hemorrhoid (swollen veins in the lower part of the rectum or anus) ointment in the treatment of…
- Trial name
- NCT01881282
- Testing
- Carraghenates Cream, Mayinglong Musk Hemorrhoid Ointment
- Where
- China
- Volunteers
- 123 people
- Sponsor
- Xian-Janssen Pharmaceutical Ltd.
Reflux Disease, Gastro-Esophageal, Hiatal Hernia
Treatment of Reflux With Sleeve Gastrectomy
In 2008, the World Health Organization (WHO) report found that 0.5-1.5 billion people aged 20 years and above suffer from overweight (body mass index (BMI) ≥ 25) and obesity (BMI ≥ 30 kg / m2) stated.
- Conditions
- Reflux Disease, Gastro-Esophageal, Hiatal Hernia, Reflux Esophagitis
- Trial name
- NCT06170060
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Yusuf Emre ALTUNDAL
Computed Tomography, Carcinogenesis
CT Carcinogenic Risk in Patients With Appendicitis
The purpose of this study is to compare the incidence rate of leukemia between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
- Conditions
- Computed Tomography, Carcinogenesis, Radiation Exposure, Appendicitis
- Trial name
- NCT03776435
- Testing
- Abdomen CT
- Where
- South Korea
- Volunteers
- 1,000,000 people
- Sponsor
- Seoul National University Bundang Hospital