Clinical trials: Brain Function
Cerebral Palsy (CP)
Effect of a Humanoid Robot With Virtual Reality Games to Train Arm Function in Children With Cerebral Palsy - THRIVE Trial
About 60% of children with cerebral palsy (CP) have impaired arm function. Improving arm function requires hundreds of repetitions per day, which is impossible in a single clinical visit.
- Trial name
- THRIVE (NCT06881407)
- Testing
- Robot, Virtual Reality
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Georgia State University
Brain Tumor, Central Nervous System Neoplasms
Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment
The aim of this study is to follow up with all of the pediatric brain tumor patients who received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which there is baseline neuropsychological testing in…
- Trial name
- NCT01180881
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Massachusetts General Hospital
Fragile X Syndrome
Optical Imaging as a Tool for Monitoring Brain Function in Fragile X Syndrome
The objective of this project is to explore the potential of functional near- infrared spectroscopy (fNIRS) as innovative functional biomarker for clinical trial readiness in Fragile X Syndrome (FXS) that is still without cure.
- Trial name
- NCT06293027
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Cerebral Palsy
Comparative Effects of Myofascial Stretch and Contract-relax in Children With Spastic cp
Cerebral palsy (CP) is primarily a neuromotor disorder that affects the development of movement, muscle tone and posture.It is one of the three most common lifelong developmental disabilities, the other two being autism and…
- Trial name
- NCT06292507
- Testing
- MYOFASCIAL STRETCH, CONTRACT-RELAX TECHNIQUE
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Cerebral Palsy
Effects of Trunk Stability Exercises on Hand Function in Children With Cerebral Palsy
Rationale of this research is to evaluate the outcome of trunk stabilizing exercises on the fine motor skills of subjects with hemiplegic CP.
- Trial name
- NCT05491863
- Testing
- conservative physiotherapy plan, trunk stability exercise plan
- Where
- Pakistan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Attention Deficit Hyperactivity Disorder
Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder
The aims of the current study are to examine gene-environment interactions associated with norepinephrine (NE) system genes (ADRA2A, SLC6A2) in ADHD, and to evaluate whether genetic changes in norepinephrine pathway are…
- Trial name
- NCT01912352
- Testing
- Methylphenidate
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Cerebral Palsy (CP), Balance
Sensory Integration Therapy and Function in Cerebral Palsy
Cerebral palsy (CP) is a non-progressive neurological disorder that affects movement, posture, and functional abilities. Children with CP frequently experience impairments in motor control, sensory processing, balance, postural…
- Conditions
- Cerebral Palsy (CP), Balance, Sensory Integration Disorder
- Trial name
- NCT07278635
- Testing
- Sensory Integration Therapy, Balance and Coordination Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Yeditepe University
Spastic Cerebral Palsy (sCP)
Rhythmic Stabilization Versus Ball Balancing
Spastic Cerebral Palsy (CP) is the leading cause of upper motor neuron syndrome (UMN) in children. The primary factors contributing to motor behavior disorders in these children are impairments in motor control and muscle…
- Trial name
- NCT06673849
- Testing
- Rhythmic Stabilization, Ball Balancing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Concussion, Mild Traumatic Brain Injury
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion (Acute Phase)
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the acute period after concussion.
- Trial name
- Breathe - PED (NCT07572734)
- Testing
- Paced breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hemiplegic Cerebral Palsy
A Study on Safety of tDCS One-shot in UCP
The study aims to evaluate the safety and the feasibility of transcranial Direct Current Stimulation (tDCS) session in children and young adults with Unilateral Cerebral Palsy (UCP).
- Trial name
- NCT03137940
- Testing
- real tDCS
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- IRCCS Fondazione Stella Maris
Growth Hormone Deficiency, Idiopathic Short Stature
Skeletal Muscle Effects of GH in Boys
The purpose of the study is to measure the functional effects of recombinant GH in skeletal muscle, in addition to growth promotion, in short prepubertal boys with either growth hormone deficiency or idiopathic short stature.
- Trial name
- NCT04020913
- Testing
- Somatropin injection
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Child Development, Motor Skills
Motor-Focused Exercise and Brain Development in Preschool Children
This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children.
- Conditions
- Child Development, Motor Skills, Neurodevelopment, Brain Function
- Trial name
- MoBraD (NCT07307742)
- Testing
- Motor-Focused Physical Education, Ordinary Physical Education
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Hunan Normal University
Cerebral Palsy, Hemiplegic
Effects of Robotic Hand Therapy on Hand Function and Dexterity in Cerebral Palsy
This randomized controlled trial aims to evaluate the effects of robotic hand therapy using the Syrebo E12 soft-robotic glove compared with conventional physiotherapy on hand function and manual dexterity in children with…
- Trial name
- NCT07571668
- Testing
- Robotic Hand Therapy, Conventional physical Therapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Riphah International University
Traumatic Brain Injury
Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases.
- Trial name
- NCT04530032
- Testing
- ketogenic/modified Atkins diet, Standard diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Middle Meningeal Artery Embolization, Chronic Subdural Hematomas
Middle Meningeal Artery Embolization in Patients With Chronic Subdural Hematoma
Primary : to evaluate the efficacy of MMAE on resolution and recurrence of hematoma in patients with CSDH. Secondary : evaluate the effect of MMAE on functional outcome, radiological changes, the need to repeat surgery, duration…
- Trial name
- NCT07806552
- Testing
- middle meningeal artery embolization
- Volunteers
- 35 people
- Sponsor
- Assiut University
Parkinson Disease
Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)
In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking.
- Trial name
- NCT00993291
- Testing
- Frequency change to 60 Hz, Frequency change to 130 Hz
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Neurodevelopmental Disorders, Child Behavior Disorders
Impact of General Anesthesia in Childhood on Cognitive Processes
This study aims to evaluate the potential long-term cognitive effects of general anesthesia administered before the age of 4. Specifically, it investigates executive functions-including inhibition, working memory, and cognitive…
- Trial name
- NCT07141797
- Testing
- Executive functions assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cerebral Palsy
Effect of Intrathorathic Oscillations on Pulmonary Functions in Children With Cerebral Palsy
Aim: To investigate the effect of intrathoracic oscillations on forced expiratory volume at first second and peak expiratory flow in the children with cerebral palsy.
- Trial name
- NCT05252663
- Testing
- Quake device training, Traditional chest physiotherapy
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Cerebral Palsy, Hemiparesis
Whole Body Vibration Versus Functional Strength Training On Balance In Children With Hemiparetic Cerebral Palsy
The study will be directed to compare which of whole body vibration (WBV) training and Functional strength training (FST) has better effect on balance in children with hemiparesis
- Trial name
- NCT05936554
- Testing
- whole body vibration, Functional strength training
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Amany Ibrahim AbdElhamed Sabra
Traumatic Brain Injury
Functional and MRI Evaluation of the Robot-assisted and Traditional Rehabilitation Programs on the Muscle
Walk recovery is one of the goals of rehabilitation programs in patients with acquired brain injury. Recent experiences have shown the effectiveness of rehabilitation programs including traditional physiotherapy in combination…
- Trial name
- NCT04768192
- Testing
- Physical Rehabilitation without lokomat, Physical Rehabilitation with Lokomat
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Eugenio Medea
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