Clinical trials: Brain MRI
Drug Resistant Epilepsy
Epileptogenic Network Visualisation With Advanced MRI
The goal of this clinical trial is to improve non-invasive identification of epileptogenic networks in drug-resistant epileptic patient.
- Trial name
- EPIVAM (NCT06059157)
- Testing
- Advanced MRI
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ADHD - Attention Deficit Disorder With Hyperactivity
Brain Stimulation and Attention Control in Children With ADHD
The goal of this clinical trial is to learn if brain stimulation can help children ages 6 to 12 with attention-deficit/hyperactivity disorder (ADHD) improve their attention and self-control.
- Trial name
- NCT07182344
- Testing
- Intermittent Theta Burst Stimulation to Right DLPFC
- Where
- 2 sites in Kazakhstan
- Volunteers
- 40 people
- Sponsor
- Neurolab Plus
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Encephalopathy, Developmental Delay and Behavioral Changes
RCT for Intermittent Versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
RCT for Intermittent versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
- Conditions
- Encephalopathy, Developmental Delay and Behavioral Changes, Cord Tumor Compression or Instability, Cord Tethering or Malformation
- Trial name
- NCT00515359
- Testing
- Intermittent Propofol Sedation, Continuous Propofol Sedation
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Corewell Health West
MPS IIIB (Sanfilippo B Syndrome)
Evaluation of Blood Brain Barrier Integrity and Structural Abnormalities in MPS IIIB Patients Using Multimodal Magnetic Resonance Imaging
The purpose of the study is to characterize structural abnormalities in the brain and the integrity of the blood brain barrier in patients with mucopolysaccharidosis type IIIB (MPS IIIB).
- Trial name
- NCT02090179
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Brain Cancer
Controlling Coordination After Childhood Cerebellar Cancer, a Pilot Study
Posterior fossa tumours (PFT) account for 2/3 of childhood brain cancers. They can be highly malignant requiring combined chemotherapy and radiotherapy post-surgery for a >50% chance of cure.
- Trial name
- 5C-pilot (NCT04501731)
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Imaging (MRI), Motor assessment
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Conditions Requiring a Brain Magnetic Resonance Imaging, Head Computerized Tomography, or Head Ultrasound
Low Field and High Field Magnetic Resonance Imaging Assessments on Pediatric Patients
Hyperfine Research, Inc. has taken advantage of technological advances and developed an MRI device that is not only portable, but also uses a very-low magnetic field strength, [less than 0.2 Tesla or approximately 10 times less]…
- Trial name
- NCT04629469
- Testing
- Hyperfine MRI
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Children's Mercy Hospital Kansas City
Cognitive Impairment, Dementia
Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the…
- Conditions
- Cognitive Impairment, Dementia, Affective Disorders
- Trial name
- NCT03335696
- Where
- United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Hypoxic-Ischemic Encephalopathy
School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy
Neonatal HIE increases the risk for cognitive impairments in childhood. Neonatal MRI brain scans are a strong predictor for outcome, however a normal scan has only a 35% sensitivity and 85% specificity for a normal outcome.
- Trial name
- SOPHIE (NCT07770035)
- Where
- Ireland
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University College Cork
Auditory Processing Disorders
Contribution of Functional MRI in Assessment of Auditory Processing Disorders
Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability.
- Trial name
- IRMf-TTA (NCT03887182)
- Testing
- functional MRI, Automated Cortical Brainstem Auditory Evoked Potential, whole exome sequencing
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy
MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events
This is a nested cohort study in the PRO-SVD cohort. Small vessel disease is a chronic disease and is thought to progress over time.
- Conditions
- Intracerebral Hemorrhage, CAA - Cerebral Amyloid Angiopathy, Cerebral Small Vessel Diseases
- Trial name
- MRI-PRO-SVD (NCT05773235)
- Testing
- Combined 3- and 7 Tesla-MRI
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Effects of Neurotoxicants on the Brain
PERINE : Effect of Prenatal Exposure to Neurotoxicants on the Developing Brain : an MRI Study
This project aims at evaluating the consequences of prenatal exposure to neurotoxicants (solvents, organophosphate pesticides) on the developing brain, in children aged from 10 to 12 years.
- Trial name
- PERINE (NCT02125110)
- Testing
- MRI, neuropsychological assessment
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Traumatic Brain Injury
Brain Injury Assessment Study at Hennepin County Medical Center
The goals of this study are to develop an objective, multi-modal classification scheme and outcome measures for traumatic brain injury based on several measures: (1) blood-based biomarkers (indicates which cell types are…
- Trial name
- BASH (NCT02706574)
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- CentraCare
Epilepsy
Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database
Objectives: The overall study objective is to compare the sensitivities and specificities of morphometric analysis techniques using structural MRI images based on pre- and postsurgical localization of epileptic foci in patients…
- Trial name
- NCT02107989
- Testing
- MRI, MEG
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Movement Disorders
Evaluation of Diffusion MRI as a Tool in Planning Deep Brain Stimulation (DBS)
The purpose of this study is to explore the relationship between deep brain stimulation implantation site and DTI (diffusion tensor imaging) derived measures for the region and later compare this to the clinical treatment…
- Trial name
- NCT01975532
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Post-concussion Syndrome, Post-concussive Symptoms
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin
PURPOSE: The long-term goal of this line of research is to develop rational, biologically based evidence for the treatment of post-concussion syndrome (PCS) in children.
- Conditions
- Post-concussion Syndrome, Post-concussive Symptoms, Traumatic Brain Injury, Concussion
- Trial name
- PLAYGAME (NCT01874847)
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Neurofibromatosis Type 1, Brain Tumor
Feasibility and Clinically Application of Magnetic Resonance Fingerprinting
This study will look at the feasibility of using magnetic resonance fingerprinting (MRF) in children, adolescents and young adults (AYA) with and without brain tumors.
- Conditions
- Neurofibromatosis Type 1, Brain Tumor, Glioma
- Trial name
- NCT02387840
- Testing
- Magnetic Resonance Imaging, Magnetic Resonance Fingerprinting
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Focal Epilepsy
Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy
Multicentre cross-sectional study with prospective recruitment comparing the detection rate of lesions on brain MRI without and with quantitative volumetry and T1 relaxometry information during the management of children with…
- Trial name
- ORACLE (NCT05100771)
- Testing
- Pediatric brain MRI
- Where
- 5 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Tours