Clinical trials: Breast Lesion
Breast - Female, Dense Breast Parenchyma
Evaluation and Reclassification of ( BI-RADS 3) Breast Lesions in Dense Breast
This prospective study aims to compare combined breast ultrasound (US) and digital mammography (DM) with digital breast tomosynthesis (DBT) in the evaluation and reclassification of BI-RADS 3 (probably benign) breast lesions.
- Conditions
- Breast - Female, Dense Breast Parenchyma, Breast Lesion, Digital Mammography
- Trial name
- NCT07804147
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Digital Breast Tomosynthesis
Value of Digital Breast Tomosynthesis in Breast Lesions
The aim of the study is to evaluate the added value of digital breast tomosynthesis (DBT) in the characterization of breast lesions.
- Trial name
- NCT06687902
- Testing
- Digital breast tomosynthesis
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Breast Cancer
Cryosurgery in Treating Women With Breast Lesions
RATIONALE: Cryosurgery kills cancer cells by freezing them. Cryosurgery followed by lumpectomy or mastectomy may be an effective treatment for breast lesions.
- Trial name
- NCT00020852
- Testing
- conventional surgery, cryosurgery
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Diseases
Radiomics Model Based on DCE-MRI and Ultrasound Images for Breast Lesion Classification
To develop and compare multi-modality radiomics models based on DCE-MRI, B-mode ultrasound (BMUS) and strain elastography (SE) images for classifying benign and malignant breast lesions.
- Trial name
- NCT06497023
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Ma Zhe
Breast Cancer, Ductal Carcinoma
Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
The goal of this research study is to evaluate the efficacy and safety of low-dose exemestane versus low-dose tamoxifen in post-menopausal women at high risk for breast cancer.
- Conditions
- Breast Cancer, Ductal Carcinoma, Estrogen-receptor-positive Breast Cancer, Atypical Lobular Hyperplasia
- Trial name
- BabyTEARS (NCT07499999)
- Testing
- Exemestane, Tamoxifen
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer Diagnosis, Breast Cancer
A Simplified Approach to Predicting the Malignancy of Breast Lesions: Nomogram in Ultrasonography
This study aims to construct and validate a quantitative mammographic model based on breast ultrasound images, incorporating patient characteristics such as age and significant sonographic features.
- Trial name
- NCT06185855
- Testing
- Retrospective Ultrasonographic Data Analysis
- Volunteers
- 550 people
- Sponsor
- RenJi Hospital
Breast Diseases
New Mammographic Techniques Versus MRI in Assessment of Breast Lesions
Value of New Mammography Techniques in Comparison to Dynamic Contrast-Enhanced MRI of the Breast in the Detection and Diagnosis of Breast lesions
- Trial name
- CEDM&DBTVSMR (NCT06089148)
- Testing
- contrast enhanced digital mammography, tomosyntheis and MRI
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer
Incidence and Prognostic Significance of HER-2 Status Discordance Between Primary Breast Cancer and Paired Recurrent/Metastatic Lesions
About a half of HER2-negative breast cancer show HER2-low expression that can be targeted by new antibody-drug conjugates. The main aim of this study is to describe the evolution of HER2 expression from primary BC to relapse by…
- Trial name
- NCT05510037
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,299 people
- Sponsor
- Fudan University
Neoplasm of Breast
Ultrasound Guided Percutaneous Microwave Ablation for Breast Lesions
The investigators will perform this study to prospectively analyse the clinical outcome after percutaneous microwave ablation(MWA) of benign and malignant breast lesion under ultrasound (US) guidance.
- Trial name
- NCT02860104
- Testing
- microwave ablation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese PLA General Hospital
Breast Neoplasms
Diffusion Coefficient and Micro-calcifications to Kaiser Score in Evaluation of BI-RADS 4 Breast Lesions
Breast cancer is the most commonly diagnosed cancer worldwide and is the leading cause of cancer-related deaths in women. Mammography, breast ultrasonography (US), and breast magnetic resonance imaging (MRI) are essential for the…
- Trial name
- NCT07033507
- Testing
- MRI diffusion coefficient and micro-calcifications to Kaiser Score in evaluation of BI-RADS 4 breast lesions
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University Hospital
Breast Diseases
Using Deep Learning and Radiomics to Diagnose Benign and Malignant Breast Lesions Based on Ultrasound
This retrospective study aimed to create a prediction model using deep learning and radiomics features extracted from intratumoral and peritumoral regions of breast lesions in ultrasound images, to diagnose benign and malignant…
- Trial name
- NCT06069921
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Ma Zhe
Breast Cancer
Quantitative Dynamic Contrast Enhanced Breast MRI
The purpose of this study is to see if dynamic contrast enhanced (DCE) MRI imaging makes it possible to distinguish benign conditions of the breast from malignant tumors and provide better information than can be obtained with…
- Trial name
- NCT00582764
- Testing
- perform dynamic contrast enhanced (DCE) MRI
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Premalignant Lesion
High-risk Breast Lesions: A Multicenter Retrospective Study
In this multicenter study, the goal was to document the excisional biopsy or follow-up results of high risk lesions diagnosed on image guided CNB/VAB, and evaluate the clinical, imaging and histologic features for associated…
- Trial name
- NCT04926688
- Where
- Turkey (Türkiye)
- Volunteers
- 1,345 people
- Sponsor
- Ege University
LAD (Left Anterior Descending) Coronary Artery Stenosis
Reconstruction of Diffusely Diseased Left Anterior Descending with Left Internal Mammary Artery On-lay Patch or Saphenous Vein Patch Without Endarterectomy by Opening the Whole Wall of the Diseased Segment(s) Has Less Risk and Fewer Complications Compared to Endarterectomy Technique
The objective of this study is to compare different surgical strategies for management of severely diseased LAD artery during CABG i.e. LIMA on-lay patch vs.
- Trial name
- NCT06835114
- Testing
- CABG, LIMA on lay patch, Safenous vein patch
- Volunteers
- 90 people
- Sponsor
- Assiut University
Non Mass Breast Lesions
Diagnostic Accuracy of Multiparametric Dynamic Contrast Enhanced Magnetic Resonance Imaging in Improving Detection of Ultrasound Non-mass Breast Lesions According to ACR BI-RADS v2025
this study aims To evaluate the diagnostic performance of Ultrasound (US) in correlation with Dynamic Magnetic Resonance Imaging (MRI) for the assessment, characterization, and evaluation of non-mass breast lesions.
- Trial name
- NCT07679308
- Testing
- multiparametric DCE- MRI and US for all patients
- Volunteers
- 60 people
- Sponsor
- Sohag University