Clinical trials: Breast Lesion
Breast Cancer
VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients
Purpose: This study will evaluate how measurements of tissue stiffness, viscosity, and anisotropy using non-invasive ultrasound imaging correlate with breast tumor malignancy and response to chemotherapy.
- Trial name
- NCT06878547
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Visibility of Lesion Characteristics With Phase Contrast Mammography
To determine if diagnostic phase contrast mammography (PCM) will provide improved image detail in assessing lesion characteristics when compared to diagnostic x-ray mammography (XM).
- Trial name
- NCT00467727
- Testing
- Phase Contrast Mammography
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
"The Efficacy of 'Radioguided Occult Lesion Localization' (ROLL) Versus 'Wire-guided Localization' (WGL) in Breast Conserving Surgery for Non-palpable Breast Cancer: a Randomized Clinical Trial"
Rationale: Approximately 25% of breast cancers detected are non palpable. Accordingly, a localization technique is required to help the surgeon to find and remove the cancer.
- Trial name
- ROLL (NCT00539474)
- Testing
- Radio guided occult lesion localisation
- Where
- 4 sites in Netherlands
- Volunteers
- 316 people
- Sponsor
- UMC Utrecht
Breast Cancer
Comparison of Two Types of Biopsy in Patients With Breast Lesions
RATIONALE: Biopsy is the removal of cells or tissue for examination under a microscope. It is not yet known which type of breast biopsy is more effective for diagnosing breast lesions.
- Trial name
- NCT00006031
- Testing
- Needle localized breast biopsy with specimen x-ray, Low dose radioactive seed followed by surgery and mammogram
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer Female, Diagnoses Disease
Ultrasound-based Diagnostic Model for Differentiating Malignant Breast Lesion From Benign Lesion
This study proposed to construct an ultrasound-based diagnostic model for Differentiating Malignant Breast Lesion From Benign Lesion.
- Trial name
- NCT03080623
- Where
- 4 sites in China
- Volunteers
- 1,981 people
- Sponsor
- Peking University
Suspicious Breast Lesion for Which Biopsy is Scheduled
Use of Low-dose Molecular Breast Imaging for the Detection of Small Breast Lesions
The purpose of this study is to show that improvements in the molecular breast imaging (MBI) technology will allow reduction of the administered dose of Tc-99m sestamibi while maintaining a sensitivity of 90% for tumor detection.
- Trial name
- Lowdoseprebx (NCT01285440)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Breast Diseases
Performance Indicators and Patient Experience in 7G and 10G Vacuum-assisted Excision of Probably Benign Breast Lesions
The purpose of this study is to assess how the needle size 7G vs 10G affects performance indicators and patient experience in vacuum-assisted excision (VAE) of probably benign breast lesions
- Trial name
- NCT04911101
- Testing
- Excision with 7G needle, Excision with 10G needle
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska University Hospital
Breast Cancer
Clinical Investigation to Evaluate the Ability of MammoWave in Breast Lesions Detection
This is a multicentric, single arm, prospective, stratified by breast density clinical investigation using Mammowave that is a device, which uses microwaves instead of ionizing radiation (X-ray)for breast lesions(BL) detection.
- Trial name
- DE-17-17 (NCT04253366)
- Testing
- Clinical investigation device class IIa not marked CE
- Where
- 3 sites in Italy, Spain
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Umbria Bioengineering Technologies
Breast Cancer
BIOPSY SCANNER LLTECH© Technology for Diagnosis of Breast Cancer
Breast cancer is a frequent pathology and the speed of initial diagnosis makes it possible to improve the course of care and to reduce the anxiety of the patients.
- Trial name
- LLTECHBreast (NCT04292821)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HER2-positive Breast Cancer
Basket Study for Oligo-metastatic Breast Cancer
The study will include patients with HER2-positive breast cancer and 1- 3 distant metastatic lesions, all amenable for curative intervention. Patients will be stratified by prior therapy and ER expression.
- Trial name
- ANISE (NCT05982678)
- Testing
- Trastuzumab deruxtecan
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Multifunctional Magnetic Resonance Imaging in Predicting Breast Lesions in Women Undergoing Mastectomy for Breast Cancer
RATIONALE: Diagnostic procedures, such as multifunctional magnetic resonance imaging, may help doctors learn the extent of disease and plan the best treatment.
- Trial name
- NCT00602316
- Testing
- gadolinium-chelate, conventional surgery, magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Metastatic Breast Cancer, Lung Metastases
Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients With Metastatic Lesions
This study will test the investigational antibody, MEDI6469 (anti-OX40), in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received systemic therapy and have…
- Conditions
- Metastatic Breast Cancer, Lung Metastases, Liver Metastases
- Trial name
- OX40 Breast (NCT01862900)
- Testing
- MEDI6469
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Providence Health & Services
Non Mass Breast Lesions
Diagnostic Accuracy of Multiparametric Dynamic Contrast Enhanced Magnetic Resonance Imaging in Improving Detection of Ultrasound Non-mass Breast Lesions According to ACR BI-RADS v2025
this study aims To evaluate the diagnostic performance of Ultrasound (US) in correlation with Dynamic Magnetic Resonance Imaging (MRI) for the assessment, characterization, and evaluation of non-mass breast lesions.
- Trial name
- NCT07679308
- Testing
- multiparametric DCE- MRI and US for all patients
- Volunteers
- 60 people
- Sponsor
- Sohag University
Benign Breast Disease
REGENERA Implant in Excised Non-Malignant Breast Lesions
The purpose of this First-in-Human pilot study is to evaluate the safety and performance of REGENERA breast implant in a selected cohort of patients with non- malignant breast lesions treated with excision or lumpectomy in whom…
- Trial name
- NCT04131972
- Testing
- REGENERA
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Tensive SRL
Benign Breast Lesions, Malignant Breast Tumours
Photo-Acoustic and Ultrasonographic Mammoscope
The aim of this study is to evaluate the negative predictive value of the Photo Acoustic Imager 3+ (PAM3+) in the detection of female breast lesions (malignant and benign)in an outpatient setting.
- Trial name
- PAUS (NCT07492589)
- Testing
- Photo-Acoustic Mammoscope Imager 3+
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Franciscus Gasthuis & Vlietland (Hospital)
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Breast Neoplasms, Tomosynthesis
Evaluation of Tomosynthesis for Characterization and the Management of Breast Lesions
Tomosynthesis is an innovative technique developed in digital mammography for obtaining a sectional image of the breast. Mammography has the main disadvantage of being an imaging projection that creates overlays, which eliminates…
- Conditions
- Breast Neoplasms, Tomosynthesis, BRCA1 Protein, BRCA2 Protein
- Trial name
- ETOLE (NCT02959398)
- Testing
- Standard mammography, Standard mammography and tomosynthesis
- Where
- 2 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Diseases
New Mammographic Techniques Versus MRI in Assessment of Breast Lesions
Value of New Mammography Techniques in Comparison to Dynamic Contrast-Enhanced MRI of the Breast in the Detection and Diagnosis of Breast lesions
- Trial name
- CEDM&DBTVSMR (NCT06089148)
- Testing
- contrast enhanced digital mammography, tomosyntheis and MRI
- Volunteers
- 40 people
- Sponsor
- Cairo University
Breast Cancer, Breast Tumor Benign
Evaluation of Carebot AI MMG Medical Device for Breast Lesion Detection and Density Assessment
Comparison of accuracy of clinician and DLAD image evaluation (Carebot AI MMG v2.2) 1. Comparison of the Accuracy of Density Assessment by Clinician and DLAD (DENS) 2.
- Trial name
- EMBLEDDA-MMG (NCT06428799)
- Testing
- Carebot AI MMG
- Where
- 3 sites in Czechia
- Volunteers
- 122 people
- Sponsor
- Carebot s.r.o.
Breast Cancer Prevention
Antler Plate on Preventing Mammary High-risk Lesions From Malignant Development
This study aims to prove whether antler disk extract can be put into clinical practice to prevent breast precancerous lesions from developing into cancer.
- Trial name
- NCT04440683
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Jilin University