Clinical trials: CES
Hepatitis B, Hepatitis A
Evaluation of Antibody Persistence & Immune Memory in Subjects Vaccinated During Adolescence With Twinrix™
This study will evaluate the immune response against Hepatitis-A (HAV) and Hepatitis B surface (HBs) antigen in healthy subjects aged 12 to 15 years (at the time of primary vaccination), who received vaccination course with GSK…
- Trial name
- NCT00875485
- Testing
- Blood sampling, Additional challenge dose
- Where
- 2 sites in Belgium, Czechia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Delirium
DELIRIUM SCREENING, INCIDENCE AND MANAGEMENT OBSERVATIONAL STUDY IN 2024 - THE CZECH REPUBLIC
Delirium in intensive care unit (ICU) settings is a frequent complication with reported prevalence of 31%. Recent data has revealed the connection between delirium and increased 30days mortality after hospital release and the…
- Trial name
- DELUSION (NCT05841368)
- Testing
- CAM-ICU, pCAM-ICU
- Where
- Czechia
- Volunteers
- 2,000 people
- Sponsor
- Brno University Hospital
5 Year Old Children Born Prematurely
Early Detection of Developmental Abnormalities of Preterm Infants at 5 Years of Age
The project is a national, prospective, multicenter, interventional pilot project focused on the follow up of 5 year old children that were born prematurely.
- Trial name
- NCT07391527
- Testing
- Pediatric check-up
- Where
- 4 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
COVID, SARS-CoV 2
COVID-19: Herd Immunity Study in the Czech Republic
The aim of the SARS-CoV-2-CZ-Preval study is to quantify the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on…
- Trial name
- SARSCoV2CZPrev (NCT04401085)
- Testing
- SARS-CoV-2 diagnostic rapid test, Quantitative analysis of SARS-CoV-2 antibodies
- Where
- Czechia
- Volunteers
- 27,000 people, healthy volunteers welcome
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Myopia
Myopia Control Effect of DIMS Spectacle Lenses in Czech Children and Young Adults
The aim of this clinical study is to compare the efficacy of DIMS technology spectacle lenses with conventional single vision spectacle lenses at slowing the progression of myopia in the category of children and young adults…
- Trial name
- NCT05943912
- Testing
- Single Vision Spectacle Lens, Defocus Incorporated Multiple Segments (DIMS) Spectacle Lens
- Where
- Czechia
- Volunteers
- 80 people
- Sponsor
- Czech Technical University in Prague
BPD - Bronchopulmonary Dysplasia, Pulmonary Hypertension
Controlled Remote Monitoring and Optimization of Oxygen Therapy in Preterm Infants
The project is a national, prospective, multicenter, interventional pilot project focused on controlled remote monitoring and optimization of oxygen therapy for premature infants in the Czech Republic.
- Trial name
- NCT07161908
- Testing
- Pulse oximeter
- Where
- 4 sites in Czechia
- Volunteers
- 70 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Tick Borne Encephalitis (TBE)
Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic
This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic.
- Trial name
- ENCZECH (NCT07274046)
- Testing
- No intervention
- Where
- 4 sites in Czechia
- Volunteers
- 209 people
- Sponsor
- Charles University, Czech Republic
Intraoperative Lung Protective Ventilation
Intraoperative Lung Protective Ventilation in Czech Republic
This questionnaire-based study aims to evaluate the adherence to and current clinical practices regarding intraoperative lung-protective ventilation (IOLPV) among anesthesiologists in the Czech Republic.
- Trial name
- IOLPVCZ (NCT07282899)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Non-technical Skills
Observation of Non-technical Skills in the Pre-hospital Care in the Czech Republic
The aim of the study is to find out if the Emergency Medical Services (EMS) crews are using the non-technical skills (e.g. communication, decision making, situational awareness etc.) in the real practice and how well they use…
- Trial name
- NTS (NCT04503369)
- Testing
- Non-technical skills
- Where
- 3 sites in Czechia
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- David Peran
Rapid Sequence Induction
Rapid Sequence Induction Czech Republic: Survey
Rapid sequence induction (RSI) is a common part of routine anesthesiology practice.However several steps of RSI are not based on evidence based data (EBM) and are considered controversial.
- Trial name
- RSICZ (NCT02985970)
- Testing
- questionnaire
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Brno University Hospital
Amyotrophic Lateral Sclerosis
Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-up
Questionnaires and scales used to assess the clinical status and quality of life of patients with amyotrophic lateral sclerosis (ALS) are an important tool to monitor the disease progression and current needs of patients.
- Trial name
- NCT06426030
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Masaryk University
Epilepsy
Efficacy and Safety of Levetiracetam in Routine Clinical Practice in Czech and Slovak Republics, Hungary, and Romania.
To evaluate, over 1 year period, the efficacy and safety of newly prescribed levetiracetam as add-on treatment (POS, myoclonoc seizures in JME and PGTCS in IGE) or primary monotherapy (partial onset seizures) in adult and…
- Trial name
- NCT00614549
- Volunteers
- 2,569 people
- Sponsor
- UCB Pharma
Multiple Sclerosis
Czech Pharmaco-epidemiological Study on Disease Modifying Drugs
Multiple sclerosis (MS) is a severe autoimmune disease that affects mainly young individuals. It is estimated that there are 17-20,000 affected persons in the Czech Republic.
- Trial name
- CPE (NCT05762003)
- Testing
- interferons, glatiramer acetate, teriflunomide, dimethyl fumarate, alemtuzumab, cladribine, fingolimod, ponesimod, rituximab, ocrelizumab, ofatumumab, natalizumab
- Where
- Czechia
- Volunteers
- 17,478 people
- Sponsor
- IMPULS Endowment Fund
Tic Disorder, Childhood
A Study of Cranial Electrotherapy Stimulation as an Add-on Treatment for Tic Disorders (SCATT)
Tic disorders is recognized as a neuropsychiatric disease. The treatments of tic disorders include drug therapy, psychotherapy and physical therapy.
- Trial name
- SCATT (NCT03705988)
- Testing
- Cranial Electrotherapy Stimulation(CES)
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Familial Hypercholesterolaemia
Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic
The project is a national, prospective, multicenter, non-interventional pilot project of screening for the disease Familial hypercholesterolaemia (FH) in newborns in the Czech Republic.
- Trial name
- CzeCH-IN (NCT05638022)
- Testing
- Total cholesterol (TC) level test and direct Low density lipoprotein cholesterol (LDL-C) level test, DNA testing
- Where
- 11 sites in Czechia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Delirium
Delirium in the (Neuro)Intensive/Critical Care in the Adult and Paediatric Czech Populations
Intensive and critical care in the intensive care unit (ICU) is often associated with ICU delirium and post-ICU dementia, regardless of the nature of the primary disease or insult.
- Trial name
- NCT05891873
- Testing
- CAM-ICU, ICDSC, 4AT
- Where
- Czechia
- Volunteers
- 700 people
- Sponsor
- Masaryk University
Mental Disorder, Mental Health Issue
Implementation and Evaluation of the ChildTaks+ Intervention in the Czech Republic
Aims of the study. The aim of this study is to evaluate the effectiveness of the ChildTalks+ intervention and to implement it in education and practice. By delivering the ChildTalks+ intervention, i.e.
- Conditions
- Mental Disorder, Mental Health Issue, Parent-Child Relations, Parent-child Problem
- Trial name
- ChildTaks+ (NCT05554458)
- Testing
- ChildTaks+ intervention
- Where
- Czechia
- Volunteers
- 65 people
- Sponsor
- Charles University, Czech Republic
Malignant Hyperthermia
Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia
The Academic centre for Malignant Hyperthermia of Masaryk University (ACMHMU) was established in 2021 in Brno, Czech Republic and consists of four academic departments of Medical Faculty of Masaryk University in two tertiary…
- Trial name
- MHCZECH (NCT05036148)
- Testing
- Data analysis
- Where
- Czechia
- Volunteers
- 286 people
- Sponsor
- Brno University Hospital
Primary Immunodeficiency Diseases (PIDD)
Expanded Access to TAK-881 for People With Primary Immunodeficiency Diseases in the USA and Czech Republic
The expanded access program allows people to gain access to an unlicensed treatment on compassionate grounds. This study will provide access to TAK-881 for participants with PIDD who have completed study TAK-881-3002…
- Trial name
- NCT06955793
- Testing
- TAK-881, SC Investigational Needle Sets
- Sponsor
- Takeda
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady