Clinical trials: CONTROL Condition
Hidradenitis Suppurativa
A Phase 3 Study to Assess Efficacy Safety and Tolerability of Remibrutinib in Adult and Adolescent Patients With Moderate to Severe Hidradenitis Suppurativa
The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
- Trial name
- RECHARGE-2 (NCT06840392)
- Testing
- Remibrutinib Dose A, Remibrutinib Dose B
- Where
- 129 sites in United States, Argentina and 17 more
- Volunteers
- 565 people
- Sponsor
- Novartis Pharmaceuticals
Aortic Valve Stenosis
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
This study will monitor the safety and valve performance of the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with symptomatic, severe, calcific aortic stenosis who are at intermediate operative risk for…
- Trial name
- NCT03517436
- Testing
- TAVR with CENTERA THV
- Where
- 23 sites in United States
- Volunteers
- 101 people
- Sponsor
- Edwards Lifesciences
Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration
Efficacy of Variable Lidocaine Concentrations in Tumescent Anesthesia for Pain Control During and After Endovenous Laser Procedure; Non-inferiority Trial
Endovenous laser treatment is a minimally invasive procedure that has been shown to be a safe and effective treatment for varicose veins.
- Trial name
- NCT02192411
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Midwest Vein Center
Attention Deficit Disorder With Hyperactivity
Safety and Efficacy of SPD503 in Treating Attention-Deficit/Hyperactivity Disorder (ADHD) in Children Aged 6-17
The purpose of this study is to assess the safety and efficacy of SPD503 (Guanfacine hydrochloride) compared to placebo in the treatment of ADHD in children and adolescents aged 6-17
- Trial name
- NCT00152009
- Testing
- SPD503 (Guanfacine hydrochloride) (2 mg), SPD503 (3 mg), SPD503 (4 mg)
- Volunteers
- 345 people
- Sponsor
- Shire
Hepatitis B
Study of Evaluating Safety and Immunogenicity of 10µg/0.5ml Hepatitis B Vaccine
The main objective of this study was to evaluate the safety and immunogenicity of 10µg/0.5ml and 5µg/0.5ml hepatitis B vaccine made by recombinant deoxyribonudeic acid techniques in saccharomyces cereviside yeast for infants and…
- Trial name
- NCT02152709
- Testing
- 3 dose of 10µg/0.5ml hepatitis B vaccine, 3 dose of 5µg/0.5ml hepatitis B vaccine
- Where
- China
- Volunteers
- 1,537 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Infant, Premature, Diseases, Mothers
Home Support for Mothers Whose Premature Infants
Premature births are a challenging process for parents in many ways. Especially after the treatment and care in the hospital, they are concerned about whether they will be able to provide adequate care for their baby at home.
- Trial name
- NCT04741672
- Testing
- Providing guidance after discharge routine procedure and calling one week after discharge., Discharge routine procedure.
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
Chronic Obstructive Pulmonary Disease
Balance Training in Patients With Chronic Obstructive Pulmonary Disease (COPD)
A growing body of evidence suggests that individuals with chronic lung disease have important deficits in balance control that may be associated with an increased risk of falls.
- Trial name
- NCT01424098
- Testing
- Balance training program
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Roger Goldstein
Neuritis
Role of PRF With MTA and Theracal After Pulpotomy in Relieving Pain
this research will evaluate the effect of PRF with different bioactive materials in dentistry
- Trial name
- NCT03493321
- Testing
- PRF with Theracal
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cairo University
Autistic Disorder
Treatment of Autism in Children and Adolescents
This study is designed to determine the effectiveness of risperidone, a drug treatment for the interfering symptoms of Autistic Disorder in children and adolescents between the ages of 5 and 17.
- Trial name
- NCT00005014
- Testing
- Risperidone
- Where
- 5 sites in United States
- Volunteers
- 101 people
- Sponsor
- National Institute of Mental Health (NIMH)
Concussion Post Syndrome
Auditory Slow Wave Enhancement After Concussion
The prevalence of a traumatic brain injury (TBI) in children and adolescents is around 30% with 70-90% being classified as mild (concussion).
- Trial name
- NCT04770116
- Testing
- Auditory Stimulation
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio
Epithelial Ovarian Cancer, Acute Kidney Injury Due to Circulatory Failure
Effect of Sodium Thiosulfate on Nephrotoxicity of Cisplatin Intraperitoneal Heat-perfusion Chemotherapy
Ovarian cancer is the most lethal malignancy of the female genital tract. Cytoreductive surgery combined with chemotherapy is the primary treatment for ovarian cancer, and radical tumor resection is an important means to improve…
- Trial name
- NCT05877911
- Testing
- Sodium Sulfate, Hydration, Cisplatin
- Volunteers
- 110 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dental Caries, Dental Pulp Exposure
MTA/FS Pulpotomy for Vital Primary Incisors: A Randomized Controlled Trial
To compare radiographic and clinical outcomes and survival of mineral trioxide aggregate/ferric sulfate (MTA/FS) pulpotomy and root canal therapy (RCT) in carious vital primary maxillary incisors.
- Trial name
- MTA/FS (NCT02019563)
- Testing
- RCT Group, MTA/FS pulpotomy Group
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- The Hospital for Sick Children
Child Behavior Problem, Preterm
I-InTERACT Preterm Parenting
Many children born very preterm experience behavior problems, and existing resources for parenting these children are lacking. A pilot trial established the effectiveness of a preterm parenting intervention, I-Interact Preterm…
- Conditions
- Child Behavior Problem, Preterm, Parent-Child Relations, Parenting
- Trial name
- I2P-RCT (NCT06767293)
- Testing
- I-InTERACT Parenting Intervention (I2P) and coaching sessions, I-InTERACT Parenting Microlearning Intervention (I2P Micro) and coaching sessions, Internet Resources
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Emergencies, Tricyclic Antidepressant Poisoning
Medical Checklists in the Emergency Department
This study aims to investigate whether the use of medical checklists in the emergency department can decrease resuscitation time in critically ill patients.
- Conditions
- Emergencies, Tricyclic Antidepressant Poisoning, Tricyclic Antidepressant Toxicity
- Trial name
- NCT05496114
- Testing
- Checklist
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Restless Legs Syndrome
A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause
The purpose of this study is to demonstrate the efficacy of rotigotine against placebo in adolescent subjects with idiopathic Restless Legs Syndrome (RLS) over a 12-week maintenance period and to investigate the safety and…
- Trial name
- NCT03728933
- Testing
- Rotigotine 1 milligram/24 hours, Rotigotine 2 milligram/24 hours
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- UCB Biopharma SRL
Infection
Prevention of Catheter-Related Bloodstream Infection in Patients With Hemato-Oncological Disease
The aim of this prospective randomised controlled trial is to compare the incidence of catheter-related bloodstream infection in 2 groups of patients with hemato-oncological disease: Group A: heparin-coated central venous…
- Trial name
- NCT00413738
- Testing
- Antiseptic-coated central venous catheters
- Sponsor
- Centre National de Greffe de Moelle Osseuse
Diet, Gluten-Free, Gluten-Sensitive Enteropathy
Non Coeliac Gluten Sensitivity in Children
Irritable Bowel syndrome (IBS) is a very frequent condition in children. Its management is difficult, often resulting in a persistence of chronical abdominal pain.
- Trial name
- NCT02895438
- Testing
- gluten
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atopic Dermatitis
Combination Therapy for Atopic Dermatitis
Atopic dermatitis is a chronic relapsing disease with acute flares. The standard therapy is to treat acute flares using topical medications.
- Trial name
- NCT00119158
- Testing
- Combination of pimecrolimus and fluticasone, pimecrolimus
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Children's Hospital of Philadelphia
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