Clinical trials: COPD
Asthma Copd
A Multicenter, Randomized, Parallel, Two-Period, Non-Inferiority Study of EurofarmavsAlenia in Asthma and COPD Treatment
A phase III study, multicenter, randomized, parallel, open, two-period, comparative non-inferiority of Eurofarma versus Alenia® in the treatment of moderate to severe persistent asthma with and without obstructive pulmonary…
- Trial name
- ESPIRE (NCT04233190)
- Testing
- Alenia® 12mcg + 400mcg / Alenia® 6mcg + 200mcg
- Where
- Brazil
- Volunteers
- 472 people
- Sponsor
- Eurofarma Laboratorios S.A.
Cystic Fibrosis (CF), Non Cystic Fibrosis Bronchiectasis
Feasibility and Acceptance of SonoHeal for Airway Clearance and Preliminary Comparison With the Standard of Care
The proposed study is to gauge the early feasibility and acceptance of the SonoHeal device. The study will evaluate the usability of the SonoHeal prototype using well-established Human Factors Engineering methods recommended by…
- Conditions
- Cystic Fibrosis (CF), Non Cystic Fibrosis Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07568119
- Testing
- Airway clearance therapy through acoustic oscillations
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cognita Labs LLC
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
COPD (Chronic Obstructive Pulmonary Disease), Chronic Bronchitis
Repeat Treatment With Metered Cryospray in Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis
This study is being conducted to determine the safety of repeat metered cryospray (MCS) treatment in patients with COPD with chronic bronchitis previously treated with MCS.
- Trial name
- MCSRETREAT (NCT07468617)
- Testing
- Metered cryospray (MCS)
- Volunteers
- 10 people
- Sponsor
- CSA Medical, Inc.
COPD (Chronic Obstructive Pulmonary Disease)
Changing Outcomes Through Achievement Emails in COPD Using Routine Healthcare Audits
This study is exploring how to improve prescribing for people with chronic obstructive pulmonary disease (COPD) in primary care. COPD is a long-term lung condition.
- Trial name
- COACH (NCT07181915)
- Testing
- Generic email - control, Personalised email - Intervention
- Where
- United Kingdom
- Volunteers
- 265 people
- Sponsor
- University of Leeds
Chronic Obstructive Pulmonary Disease (COPD), Asthma
BREZTRI REGULATORY POST MARKETING SURVEILLANCE IN KOREA
As part of a post-approval commitment requested by the Ministry of Food and Drug Safety (MFDS), this open-label, single-arm, multicentre, observational Post-Marketing Surveillance (PMS) study aims to characterize the safety…
- Trial name
- Breztri rPMS (NCT07570394)
- Where
- 10 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Interstitial Lung Disease, COPD
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs
The objective of this registry is to collect and evaluate various clinical effectiveness parameters in patients with transplanted donor lung that were preserved and transported within the LUNGguard system, as well as…
- Conditions
- Interstitial Lung Disease, COPD, Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- GUARDIANLUNG (NCT04930289)
- Testing
- LungGuard, BAROGuard
- Where
- 15 sites in United States, Belgium
- Volunteers
- 3,500 people
- Sponsor
- Paragonix Technologies
TB - Tuberculosis, PTLD
Intergrated Service Delivery for Lung Health Conditions
The Advancing Lung Health in Zambia project aims to improve access to integrated screening, diagnosis, and management of tuberculosis (TB) and other priority respiratory diseases at community and primary healthcare levels.
- Conditions
- TB - Tuberculosis, PTLD, COPD (Chronic Obstructive Pulmonary Disease), Computer Aided Diagnosis
- Trial name
- TB REACH W11 (NCT07816523)
- Testing
- Intergrated lung health screening, AI-Enabled Cough Sound Screening for Tuberculosis, Post-TB Lung Disease evaluation
- Where
- Zambia
- Volunteers
- 20,300 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
COPD
Continuous Versus High Intensity Interval Exercise in Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is characterized by exercise intolerance, which is a prognostic factor of disease severity and mortality and is usually attributed to ventilatory limitations.
- Trial name
- NCT07707271
- Testing
- Moderate intensity continuous aerobic exercise (MICE), High-intensity interval aerobic exercise (HIIE)
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- George Papanicolaou Hospital
COPD (Chronic Obstructive Pulmonary Disease)
Photon-counting CT in Chest Imaging
Purpose and objective: This project aims to evaluate photon-counting computed tomography (PCCT) quantitative accuracy using COPDGene subjects.
- Trial name
- NCT07031336
- Testing
- Photon-counting CT, Energy-integrating CT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
COPD (Chronic Obstructive Pulmonary Disease), COPD
Dupilumab in Type 2-Inflamed COPD Across the Full Spectrum of Airflow Limitation: An Italian Multicentre Retrospective Cohort Study
This multicentre retrospective cohort study describes lung function and patient-reported outcomes in adults with chronic obstructive pulmonary disease (COPD) and type 2 inflammation who received add-on dupilumab in routine…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Eosinophilia
- Trial name
- DUPICENTRO (NCT07788092)
- Testing
- Dupilumab
- Where
- 6 sites in Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera di Perugia
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE
The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Safe Volunteers
- Trial name
- BRISE (NCT07780630)
- Testing
- Fiberscopic samples, Sputum, Nasal brushing
- Where
- France
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
COPD
Respiratory Therapist-Supported Home Noninvasive Ventilation in Stable Severe COPD Without Hypercapnia
Chronic obstructive pulmonary disease (COPD) can cause persistent breathing problems, reduced exercise capacity, and repeated worsening of symptoms. Noninvasive ventilation (NIV) provides breathing support through a mask.
- Trial name
- COPD (NCT07777497)
- Testing
- BreathePal Bilevel Positive Pressure System (GFM50-MD2201)
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
COPD (Chronic Obstructive Pulmonary Disease), COPD
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study aims to see if a co-designed balance training programme called Sport4Steadiness (S4S), is acceptable to people with COPD and if the study procedures, including recruitment and the collection of outcomes, is feasible.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), COPD, Balance Exercise, Falls, Intervention
- Trial name
- B-PuRe (NCT07750821)
- Testing
- Sport4Steadiness
- Where
- 3 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Samantha Harrison
Asthma (Part 1), COPD
APP-based Medical Device for Education and Training of Inhalation Technique
Primary aim: To investigate if app-based education and training of inhalation technique improves the rate of successful inhalation techniques compared with control group at 6-12 weeks follow-up visit.
- Trial name
- APPETITE (NCT07145632)
- Testing
- App-based education and training of inhalation technique
- Where
- 3 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
COPD (Chronic Obstructive Pulmonary Disease), Asthma Copd
Self-Management in Adults With Asthma or COPD
This study is a single-blind (evaluator-blind), parallel-group randomized controlled trial comparing two approaches to home-based pulmonary rehabilitation self-management training in individuals with chronic respiratory disease…
- Trial name
- NCT07742085
- Testing
- Video Animation, brochure education
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Mustafa Kemal University
COPD
Respiratory Muscles in End-stage Lung Disease: Pathophysiological Processes & Clinical Consequences
Rationale: In patients with chronic lung diseases, the role of respiratory muscle dysfunction has been underestimated. Also, current treatment options, like chronic NIV and lung transplantation (LTx), might also have deleterious…
- Trial name
- Re-MAP (NCT06935825)
- Where
- 4 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
COPD (Chronic Obstructive Pulmonary Disease)
Effects of Alternate Nostril Breathing and Bellows Breath in COPD Patients
COPD is a common respiratory disease characterized by progressive airflow obstruction, dyspnea, chronic cough, and sputum production.
- Trial name
- NCT07719192
- Testing
- alternate nostril breathing, bellows breath
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Cystic Fibrosis, COPD
High Resolution Micro OCT Imaging
The purpose of this study is to learn about using the imaging to make images of the lungs and nose with the long-term goal of the research leading to potential treatments and new therapies for patients with cystic fibrosis.
- Conditions
- Cystic Fibrosis, COPD, PCD - Primary Ciliary Dyskinesia, Covid19
- Trial name
- NCT03256773
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
COPD
Effect of Combined Endurance Training on ADL and Walking in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with related exercise intolerance and marked disability due to symptoms such as dyspnea and fatigue.
- Trial name
- NCT05708443
- Testing
- LL group, L+UL group
- Where
- 3 sites in Italy
- Volunteers
- 36 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA