Clinical trials: COX-2 Inhibitor
Orthodontic Pain (D013850)
Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain
The purpose of this study is to compare the efficacy of selective COX-2 inhibitors{ etoricoxib vs celecoxib )in relieving orthodontic pain , after initial bonding and arch wire insertion.
- Trial name
- EOSCOX2 (NCT07559682)
- Testing
- Celecoxib, Etoricoxib (Treatment Group)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Sharif Medical Research Center
Biliary Atresia, Kasai Portoenterostomy Status
Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia
In this clinical study, meloxicam will be used to the patients who are older than 2 years and underwent Kasai portoenterostomy to treat their biliary atresia before.
- Trial name
- NCT02298218
- Testing
- Meloxicam
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Obsessive-Compulsive Disorder, Pediatric Psychiatric Disorder
Adjunctive Celecoxib in Childhood-onset OCD Study
This is a randomized, controlled, single-centre phase II superiority trial to determine the efficacy of 12 weeks of celecoxib (50 mg or 100 mg orally twice daily, dosed based on weight) compared to placebo as an adjunct to…
- Trial name
- ACE-OCD (NCT04673578)
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of British Columbia
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Emergency Contraception, Contraception
Rct Assessing Pregnancy - Piroxicam for Ec With Levonorgestrel
This randomized controlled trial will test oral levonorgestrel + piroxicam vs. levonorgestrel + placebo for emergency contraception in a representative U.S.
- Conditions
- Emergency Contraception, Contraception, COX-2 Inhibitor
- Trial name
- RAPPEL (NCT07449299)
- Testing
- Levonorgestrel 1.5 mg and Piroxicam 40 mg
- Volunteers
- 1,458 people
- Sponsor
- University of Utah
Precancerous Condition
Aspirin Mouthwash in Treating Patients With Oral Leukoplakia
RATIONALE: Aspirin mouthwash may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of aspirin mouthwash in treating…
- Trial name
- NCT01238185
- Testing
- acetylsalicylic acid, gene expression analysis, protein expression analysis
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Institute of Head and Neck Studies and Education, United Kingdom
Pain
Rofecoxib to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of a new non-steroidal anti-inflammatory drug (NSAID) called rofecoxib to prevent pain following third molar (wisdom tooth) extraction.
- Trial name
- NCT00026819
- Testing
- Rofecoxib
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Lung Cancer
Celecoxib in Treating Patients With Stage I, Stage II, or Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Studying samples of tissue, blood, and urine from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00653250
- Testing
- celecoxib, biopsy, therapeutic conventional surgery
- Volunteers
- 22 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Colorectal Neoplasm, Hereditary Nonpolyposis
Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers
This is a randomized, placebo-controlled Phase I/II multi-center trial, of the safety and efficacy of Celecoxib in a cohort of 81 HNPCC subjects and gene carriers.
- Trial name
- NCT00001693
- Testing
- Celecoxib (SC-58635)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Disease, Heart Diseases
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients…
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Myocardial Ischemia
- Trial name
- PIV-EPIC (NCT06535568)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- Italy
- Volunteers
- 576 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Postoperative Pain
Arthroplasty Inflammation Prophylaxis With Celecoxib
This double blinded, placebo controlled, study seeks to determine the efficacy of preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee arthroplasty surgery.
- Trial name
- NCT00533247
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zanbilowicz, Adam, DPM MS
Healthy, Tooth Extraction
Prostanoid Levels After Medication to Prevent Pain Following Third Molar (Wisdom Tooth) Extraction
This study will evaluate how well different medications work to relieve pain following third molar (wisdom tooth) extraction. Scientists believe that hormone-like substances called prostanoids contribute to pain following oral…
- Trial name
- NCT00078104
- Testing
- Extraction of wisdom teeth
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Primary Hypertrophic Osteoarthropathy
Effect Observation Study of COX-2 Inhibitor to Treat Primary Hypertrophic Osteoarthropathy
The purpose of this study is to determine whether COX-2 inhibitor is effective in the treatment of primary hypertrophic osteoarthropathy
- Trial name
- EOSCITPHO (NCT02438709)
- Testing
- COX-2 inhibitor
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pain
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain.
- Trial name
- NCT00115752
- Testing
- Valdecoxib, COX Inhibitor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)