Clinical trials: Cancer Progression
Attention-deficit Hyperactivity Disorder
A Study to Examine the Progression of Attention-Deficit Hyperactivity Disorder (ADHD) Drug Treatment and to Analyze Associated Factors
The purpose of this observational study is to explore the efficacy of methylphenidate hydrochloride in children and adolescents diagnosed with attention-deficit hyperactivity disorder (ADHD) by Kiddie-scheduled for affective…
- Trial name
- NCT01624649
- Testing
- Methylphenidate hydrochloride, Atomoxetine
- Where
- 9 sites in South Korea
- Volunteers
- 289 people
- Sponsor
- Janssen Korea, Ltd., Korea
HIV Infections
A Comparison of Two Anti-HIV Treatment Plans
The purpose of this study is to compare 2 treatment plans to try to increase the effects of anti-HIV drugs in patients who are resistant to the drug effects.
- Trial name
- NCT00005915
- Where
- 21 sites in United States
- Volunteers
- 480 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Retinitis Pigmentosa
Studying a Potential Protective Effect of L-Dopa on Retinitis Pigmentosa
The purpose of this study is to evaluate the effect of L-Dopa on the progression of retinitis pigmentosa.
- Trial name
- NCT02837640
- Testing
- levodopa-carbidopa
- Where
- Lebanon
- Volunteers
- 50 people
- Sponsor
- Beirut Eye Specialist Hospital
Neuroendocrine Tumors, Carcinoma, Neuroendocrine
Natural History Study of Children and Adults With Neuroendocrine Neoplasms (NEN)s
Background: Neuroendocrine neoplasms (NENs) are rare tumors that originate in neuroendocrine cells. NENs can affect almost any part of the body. People with low-grade tumors can live many years.
- Trial name
- NCT04488263
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Myopia
Controlling Myopia Progression With Soft Contact Lenses (Contact Lens Control)
This study is to investigate whether novel soft contact lens optical designs can slow myopia progression
- Trial name
- NCT01829191
- Testing
- Soft Contact Test Lens A, Soft Contact Test Lens C
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome
Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or Recurrent Myeloid Leukemia After Undergoing Donor Stem Cell Transplant
This phase I/II trial is studies the side effects of giving therapeutic allogeneic lymphocytes together with aldesleukin and to see how well it works in treating patients with high-risk or recurrent myeloid leukemia after…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
- Trial name
- NCT00052598
- Testing
- therapeutic allogeneic lymphocytes, aldesleukin, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Fred Hutchinson Cancer Center
Idiopathic Membranous Nephropathy, Proteinuria
A Controlled Study of Steroids Plus Cyclosporin Therapy for Patients of Idiopathic Membranous Nephropathy
This prospective, randomized, controlled, multicenter clinical trial will evaluate Opportunity, Validity and Security of Steroids Plus Cyclosporin therapy for patients of Idiopathic Membranous Nephropathy.
- Conditions
- Idiopathic Membranous Nephropathy, Proteinuria, Spontaneous Remission, Steroid Nephropathy
- Trial name
- NCT02173106
- Testing
- steroid & Cyclosporin
- Where
- 6 sites in China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
High Grade Glioma
Predicting Sites of Tumour Progression in the Invasive Margin of Glioblastomas (PRaM-GBM Study)
Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour.
- Trial name
- PRaM-GBM (NCT03294434)
- Testing
- Diffusion tensor Imaging (DTI)
- Where
- United Kingdom
- Volunteers
- 147 people
- Sponsor
- CCTU- Cancer Theme
Autosomal Dominant Polycystic Kidney Disease
A Study to Evaluate Homocysteine Metabolism and Endothelial Function in ADPKD
The purpose of this study is to assess homocysteine metabolism and systemic endothelial function at the early stages of the disease and determine the prognostic value of homocysteine, related metabolites, and markers of…
- Trial name
- HCY (NCT05193981)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Hepatitis B, Chronic
A Clinical Research on Disease Progression and Intervention of Chronic HepatitisB
HBV(hepatitis B virus) with metabolic comorbidities may accelerate liver disease progression and increase the risk of HCC(Hepatocellular Carcinoma)development.
- Trial name
- NCT05057065
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Hong Ren
Lupus Nephritis
Comparison Between Tacrolimus (TAC) and Mycophenolate Mofetil (MMF) for Induction of Remission in Lupus Nephritis
Prospective, multi-center, randomized, controlled, trial to compare tacrolimus with mycophenolate mofetil (MMF) for induces complete remission in lupus nephritis patients. The study duration is one year.
- Trial name
- NCT01580865
- Testing
- Tacrolimus vs. Mycophenolate mofetil for Induction Therapy in Lupus Nephritis
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Ramathibodi Hospital
Neurofibromatosis Type 1
Prevalence, Clinical Characteristics, Progression, and Management of Neurofibromatosis Type 1 in Egypt (NF1-Egy)
Neurofibromatosis type 1 (NF1), a genetic disorder, results from NF1 gene mutations with nearly complete penetrance (1). NF1 is considered common as a rare disease; it has a birth incidence of approximately one every 3000 and a…
- Trial name
- PRECIOUS Egypt (NCT07221331)
- Where
- 9 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Cystic Fibrosis
Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI
This is an observational study for children with Cystic Fibrosis (CF) who are eligible based on their CF gene type. One group will be called the treatment group because they have the gene type (homozygous F508del) that makes them…
- Trial name
- NCT02848560
- Testing
- Hyperpolarized Xenon
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Keratoconus
Identification and Validation of Functional Biomarkers for Keratoconus
There is currently no medication for containing KC, nor any adequate biomarkers to predict the disease. Furthermore, there is considerable confusion in the field regarding the pathophysiology of the disease and involvement of…
- Trial name
- NCT01746823
- Testing
- Cyclosporins
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Narayana Nethralaya
Breast Cancer
INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer
This is a phase II, randomized, multi-center, parallel design, window of opportunity trial evaluating intratumoral INT230-6 in up to 90 patients with early stage breast cancer.
- Trial name
- NCT04781725
- Testing
- INT230-6, Saline injection
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Myopia
Examination of Myopia Progression and Soft Bifocal Contact Lens Myopia Control
This project intends to provide important, previously unmet answers regarding biological associations with myopia (nearsightedness) progression in order to improve the ability to predict patients who are most likely to benefit…
- Trial name
- BLINK2 (NCT04080128)
- Testing
- Contact lenses
- Where
- 2 sites in United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Adolescent Idiopathic Scoliosis
Effect of a Postural Re-education Intervention Compared to Standard Care on Scoliosis Progression in Adolescent
The aim of this project is to verify the effect of the global postural reeducation (GPR) intervention used in physiotherapy on scoliosis progression (scoliosis angle), back pain, quality of life, respiratory function, trunk…
- Trial name
- RCT-RPG (NCT04568759)
- Testing
- Global postural re-education
- Where
- 2 sites in Canada
- Volunteers
- 47 people
- Sponsor
- St. Justine's Hospital
Type 2 Diabetes
Artificial Intelligence-based Methods to Predict Disease Progression in Youth With Type 2 Diabetes
Currently, clinicians are unable to predict a patient's risk of long-term disease progression and development of a long-term complication based on the data that is available to them.
- Trial name
- NCT07116902
- Testing
- phone application, Standard of Care (SOC)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Myopia Progression
The Effect of Myopia-Control Contact Lenses in New Zealand Chinese Children
The study will employ a randomized, controlled, investigator-masked paired-eye comparison design to evaluate the effects of two myopia-control contact lenses-MiSight 1 Day and Abiliti 1-Day-in New Zealand Chinese children.
- Trial name
- NCT07535749
- Testing
- MiSight Contact Lenses (CooperVision), Albiliti 1-Day (Johnson and Johnson, VisionCare)
- Where
- New Zealand
- Volunteers
- 66 people
- Sponsor
- Aston University
Aggressive Periodontitis
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
Although of low prevalence, aggressive periodontitis is a rapid destructive form of periodontal disease that initiates at a young age, leading to premature loss of first molars and incisors.
- Trial name
- NCT01330719
- Testing
- Diseased periodontal treatment, Conventional periodontal treatment
- Where
- 10 sites in United States
- Volunteers
- 514 people, healthy volunteers welcome
- Sponsor
- University of Florida