Clinical trials: Cardiac Diastolic Function
Ventricular Dysfunction, Asthma in Children
Evaluation of Cardiac Biomarkers and Ventricular Function in Asthmatic Children
Evaluation of cardiac biomarkers and the left and right ventricular systolic and diastolic function in asthmatic children in Assuit university hospital
- Trial name
- NCT05985720
- Volunteers
- 50 people
- Sponsor
- Assiut University
Pulmonary Hypertension, Diastolic Heart Failure
Phosphodiesterase-5 (PDE5) Inhibition and Pulmonary Hypertension in Diastolic Heart Failure
Prevalence of heart failure (HF) with left ventricular (LV) diastolic dysfunction and preserved ejection fraction (EF) (HFpEF) is increasing.
- Trial name
- NCT01156636
- Testing
- Sildenafil
- Volunteers
- 44 people
- Sponsor
- University of Milan
Acute Myocardial Infarction, Diabetes Mellitus
Coronary Flow Reserve and Glucometabolic State
Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients.
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Prediabetes
- Trial name
- NCT00845468
- Where
- Denmark
- Volunteers
- 190 people
- Sponsor
- Medicinsk Forsknings Afdeling
Fetal Growth Restriction
Evaluation of Fetal Heart
Evaluation of fetal cardiac functions in cases complicated with growth restriction
- Trial name
- NCT07760194
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertrophic Cardiomyopathy
Pirfenidone to Treat Hypertrophic Cardiomyopathy
This study will examine the effectiveness of the drug pirfenidone (Deskar) in improving heart function in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00011076
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Regurgitation, Congenital Heart Disease
Right Ventricular Diastolic Function in Chronic Adverse RV Loading And Congenital Heart Disease
The aim of the study is to assess the characteristics, incidence and predictors of load-independent right ventricle (RV) diastolic dysfunction in patients with congenital heart disease (CHD) and adverse RV loading conditions by…
- Trial name
- RaDICAL-CHD (NCT03471936)
- Testing
- Acquisition of pressure-volume-loops
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Heart Center Leipzig - University Hospital
Fetal Growth Retardation
Fetal Cardiac Function
The aim of our study is to evaluate the effect of PE and FGR on fetal cardiac function. Pregnancies with preeclampsia and FGR, and preeclampsia with normal fetal growth are evaluated by echocardiography and compared with…
- Trial name
- NCT06381258
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Left Ventricular Diastolic Function
Impact of Sacubitril/Valsartan on LV Diastolic Function in HFrEF
This prospective cohort study evaluates the effects of six months of sacubitril/valsartan (ARNI) therapy on left ventricular diastolic function in patients with heart failure with reduced ejection fraction (HFrEF) using…
- Trial name
- NCT07157527
- Volunteers
- 70 people
- Sponsor
- Assiut University
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Ischemic Heart Disease
Association Between IVUS and OCT Parameters and Invasive Physiologic Indices
1. to evaluate diagnostic accuracy and performance of IVUS and OCT-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices. 2.
- Trial name
- NCT03795714
- Testing
- IVUS or OCT and Invasive physiologic indices
- Where
- 2 sites in South Korea
- Volunteers
- 166 people
- Sponsor
- Seoul National University Hospital
Congenital Heart Disease, Fontan
Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients
The study involves documenting the effects of inhaled nitric oxide upon ventricular-arterial coupling in patients with congenital heart disease and passive pulmonary blood flow.
- Trial name
- NCT01607983
- Testing
- inhaled nitric oxide
- Where
- United States
- Sponsor
- University of California, San Francisco
Single-ventricle, Congenital Heart Disease
Fontan Imaging Biomarkers (FIB) Study
The goal of the Fontan Imaging Biomarkers (FIB) study is to identify the associations of blood and urine biomarkers to imaging parameters of ventricular mechanics.
- Trial name
- FIB (NCT03119090)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Fabry Disease
Impact of Agalsidase Alfa Therapy on Cardiac funcTION in Patients With Fabry's Cardiomyopathy
Study Design: This is an observational study. No treatment or intervention will be assigned to the subjects. All patients will receive full standard of care concomitant medication for the treatment of their cardiac condition.
- Trial name
- NCT03230591
- Testing
- Echocardiography
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Type 1, Systolic Dysfunction
Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus
The goal of this clinical trial is to learn about the effect of type 1 diabetes mellitus on cardiac functions and evaluate the correlation of the dysfunction with the tumor necrosis factor-α (TNF-α) an inflammation-related…
- Conditions
- Diabetes Mellitus, Type 1, Systolic Dysfunction, Diastolic Dysfunction
- Trial name
- NCT06129448
- Testing
- transthoracic echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sirnak State Hospital
Fabry's Disease
Impact of Enzyme Replacement Therapy on Cardiac Function in Patients With Fabry's Cardiomyopathy (RECAFTURE Trial)
The purpose of this study is to evaluate the impact of ERT on LV diastolic function and flow in patients with Fabry's cardiomyopathy using diastolic stress echocardiography, LV vortex flow and CMR.
- Trial name
- NCT02469181
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Congenital Heart Disease
Imaging Assessment of Diastolic Function
Diastolic function is poorly studied in children with congenital heart disease. This is mainly due to the lack of validated techniques. Cardiac MRI offers two advantages compared to echocardiography: 1.
- Trial name
- NCT01668264
- Testing
- Echocardiograph, Magnetic Resonance Imaging (MRI)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- The Hospital for Sick Children
Heart Failure Congestive
Effect of omega3 on Congestive Heart Failure
In this double blinded study patients with resynchronization pacemaker- AICD were assigned to Omega3 and placebo randomly, results indicated that Omega3 had no more effect than placebo in mortality, BNP level and 6 minutes walk…
- Trial name
- NCT01227837
- Testing
- omga3
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences