Clinical trials: Cardiac Flow
Internal Mammary Artery Syndrome, Vasodilation
Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow
Forty-six consecutive patients undergoing elective primary coronary artery bypass grafting were enrolled. After the left IMA was harvested, free flow was measured under controlled hemodynamic conditions before any intervention…
- Trial name
- NCT06301880
- Testing
- The topical application of a vasodilator on the LIMA graft
- Where
- Syria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Damascus University
Pregnancy Related, Cardiac Output
Cardiac Flow Measurements in Pregnant Women by Non Invasive Techniques
the goal of this clinical trial is to compare the measurement of cardiac output, systolic ejection volume and vascular filling in pregnant women with the new non-invasive measurement techniques of the Index of contractility…
- Trial name
- NCT06114147
- Testing
- trans thoracic echocardiography measure, ICON measure, USCOM
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Congenital Heart Disease, Bicuspid Aortic Valve
Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve
Bicuspid aortic valve (BAV) is a form of congenital heart disease (the person is born with it). With BAV, the heart valves in the aorta (the blood vessel that takes blood away from the heart to the body) are not formed right.
- Trial name
- NCT00412386
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Tricuspid Valve Insufficiency
Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart
Right-sided heart disease has an important impact on the prognosis of patients with valvular heart disease. Up to now, Tricuspid Valve Regurgitation (TR) and right heart hemodynamics have not been extensively investigated.
- Trial name
- NCT01444222
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Williams Syndrome, Supravalvular Aortic Stenosis
Impact of Elastin Mediated Vascular Stiffness on End Organs
Background: People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness.
- Conditions
- Williams Syndrome, Supravalvular Aortic Stenosis, Cardiovascular Disease
- Trial name
- NCT02840448
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Kawasaki Disease, Heart Disease
Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging
The present study is designed to: 1. investigate the safety and efficacy of Real time myocardial echocardiography (RT-MCE) in adolescents and adults ages 12-50 with congenital and acquired congenital heart disease 2.
- Trial name
- ECHOBIKE (NCT00861848)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Healthy
Estrogen Alternatives Study
Healthy postmenopausal women not currently taking hormone replacement or hormone modulating therapy take a 3-month course of estradiol/raloxifene/placebo to evaluate the effects of each on vascular function, as indicated by PET…
- Trial name
- NCT00108238
- Testing
- Estradiol followed by progesterone, Raloxifene
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Congenital Heart Disease, Pulmonary Hypertension
Integrated Computational modelIng of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease
Advances in paediatric cardiology and cardiac surgery have enabled the survival of most patients born with congenital heart disease (CHD) into adulthood.
- Trial name
- NCT03217240
- Testing
- Cardiac Magnetic Resonance - MRI, Cardiopulmonary Exercise Test, Blood Sampling for all participants
- Where
- 3 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Acute Circulatory Failure
Evaluation of Doppler Flow From the Femoral Artery as a Reflection of Cardiac Flow in a Vascular Fluid Test
In order to identify the responding patients with vascular filling test, this research aims to compare the performance of the increased flow in the femoral artery to the performance of the blood pressure increase.
- Trial name
- RER D (NCT02878369)
- Testing
- Doppler measurement of blood flow in the outflow tract of the left ventricle and the femoral artery,Reading blood pressures displayed on the monitor.
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Aortic Valve Stenosis
CPX in Paradoxical Low Flow Aortic Stenosis
Severe aortic stenosis is a condition with poor life expectancy once it becomes symptomatic. There are no prospective studies illustrating the utility of cardiopulmonary stress (CPX) testing in diagnosing and prognosticating…
- Trial name
- NCT05481814
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Right Ventricular Dysfunction, Cardiopulmonary Diseases
Right Heart and Lung Blood Flow During Exercise (RIGHT-NET 2.0)
RIGHT-NET 2.0 is a multicenter observational study with a retrospective-prospective design that builds on the original RIGHT-NET study.
- Conditions
- Right Ventricular Dysfunction, Cardiopulmonary Diseases, Pulmonary Hypertension
- Trial name
- RIGHT-NET 2 (NCT07851610)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Atrial Fibrillation, Endothelial Function
A Case Control Study to Investigate the Possible Association Between Atrial Fibrillation and Endothelium Dysfunction by Using Flow-Mediated Vasodilation Method
Endothelial function is closely related to the hemostasis , vascular tone, and organ perfusion in cardiovascular system, and its dysfunction would cause overactivation of the coagulative system to induce thrombus formation.
- Trial name
- NCT00173966
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Coronary Disease, Healthy
Study of Blood Flow in Heart Muscle
Blood flows to areas of the heart providing oxygen and fuel to the pumping muscle. Occasionally the arteries providing the fuel can become blocked. This occurs in coronary artery disease.
- Conditions
- Coronary Disease, Healthy, Hypertrophic Cardiomyopathy, Myocardial Ischemia
- Trial name
- NCT00001631
- Testing
- Magnetic resonance imaging
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiac Arrest (CA)
Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction
Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR).
- Trial name
- NCT07520877
- Testing
- T-CPR, AED-optimized T-CPR
- Where
- Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Indication, Unlabeled
Clinical Evaluation of 4D Flow Cardiac MRI Sequences
Assess the accuracy of 4D flow cardiac MRI to measure blood flow and velocity, delineate 3D cardiac anatomy and visualize flow dynamics using two (2) different pulse sequences.
- Trial name
- Eval-4DFlow (NCT03986645)
- Testing
- MR data acquisition
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emanuela Valsangiacomo
Atherosclerosis, Heart Failure, Congestive
The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function
The renin angiotensin system (RAS) plays an important physiological and pathophysiological role in the control of blood pressure and plasma volume.
- Conditions
- Atherosclerosis, Heart Failure, Congestive, Hypertension, Myocardial Infarction
- Trial name
- NCT00001628
- Testing
- Angiotensin II type 1 receptor antagonists
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)