Clinical trials: Cardiac Output
Neonatal Intensive Care
Estimation of Cardiac Output in Neonatal ICU Using an Ultrasound Dilution Technique
Presently there is no apparatus, clinically available, for routine determination of cardiac output (CO) in children. The goal of this research is to develop new technology that will help determine CO in neonates.
- Trial name
- CH (NCT01610622)
- Testing
- COstatus cardiac output measurement with isotonic saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Transonic Systems Inc.
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Perioperative Period, Cardiac Output
Cardiac Output in Children During Anesthesia
This study investigates cardiac output in young children under 18 months of age during the perioperative period by means of electrical cardiometry.
- Conditions
- Perioperative Period, Cardiac Output, Pediatric Anesthesia, Arterial Hypotension
- Trial name
- COC (NCT04044157)
- Testing
- non-invasive measurement of cardiac output
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Laszlo Vutskits
Cardiac Output, Low
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies.
- Trial name
- Corti (NCT00590018)
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Enhanced External Counterpulsation (EECP), Cardiac Output
Impact of Enhanced External Counterpulsation (EECP) on Cardiac Force Index
Regular exercise can prevent cardiovascular disease, but there is also a risk of sudden cardiac death. Exercise-related sudden death often occurs unconsciously and there is no relevant monitoring mechanism.
- Conditions
- Enhanced External Counterpulsation (EECP), Cardiac Output, Cardiac Force Index
- Trial name
- NCT05080023
- Testing
- Enhanced External Counterpulsation (EECP)
- Where
- 5 sites in Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chi-Ming Chu
Pediatric ALL
Pediatric Cardiac Output Monitoring Observational Study
To assess Cardiac Output Monitoring in pediatric subjects by comparing FloTrac and ClearSight system to intermittent thermodilution Swan-Ganz, in order to expand the indications of FloTrac, ClearSight and Swan-Ganz thermodilution…
- Trial name
- POGO (NCT04465370)
- Testing
- Hemosphere Advanced Monitoring System, ClearSight 1.5, Swan-Ganz Catheter, Flotrac, Foresight
- Where
- 3 sites in United States
- Volunteers
- 89 people
- Sponsor
- Edwards Lifesciences
Shock, Sepsis
Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO
The purpose of this study is To assess the value of dynamics (SVV, PPV) and static indices (GEDVI, ITBVI, CVP) of preload and its combination with contractility (CI,SV, ventricular power, dP/dtmax, CFI, GEF) and lung water…
- Conditions
- Shock, Sepsis, Systemic Inflammatory Response Syndrome, Low Cardiac Output
- Trial name
- PreloaDren (NCT01157299)
- Where
- 7 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario La Paz
Low Cardiac Output Syndrome
Levosimendan Administration in Neonates With Transposition of the Great Arteries
Calcium sensitizer drugs such as Levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of ATP-sensitive potassium (KATP) channels.
- Trial name
- NCT01120106
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Fluid Responsiveness
Prediction of Fluid Responsiveness by NICOM (Non-invasive Cardiac Output Monitoring) in Children With Congenital Heart Disease After Cardiac Surgery
The purpose of this study is to evaluate the ability of fluid responsiveness by stroke volume variation value of NICOM(Noninvasive cardiac output monitor)system during congenital cardiac surgery.
- Trial name
- NCT01996956
- Testing
- volume expansion
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Cardiac Output, Anesthesia
Non-invasive Cardiac Index in Children
This study investigates the level of agreement of two non-invasive cardiac output monitors (transthoracic echocardiography and electrical cardiometry) in young children under anesthesia.
- Conditions
- Cardiac Output, Anesthesia, Infant ALL
- Trial name
- NICIM (NCT06090396)
- Testing
- cardiac output monitoring with electrical cardiometry
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Laszlo Vutskits
High Frequency Oscillation, Volume Targeted Ventilation
Optimising HFO&VTV in Newborn Infants
Mechanical ventilation (MV) is life saving for infants requiring respiratory support in the newborn period but its use has been associated with complications.
- Trial name
- NCT06719284
- Testing
- HFO&VTV at targeted tidal volumes of 1.5, 2.0 and 2.5 ml/kg in random order, HFOV at the settings applied prior to the study
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College Hospital NHS Trust
Low Cardiac Output Syndrome
Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in Infants
Pediatric patients, especially infants undergoing open heart surgery have a predictable fall in cardiac index 6 to 18 hours after surgery, the so-called low cardiac output syndrome (LCOS).
- Trial name
- Levomil (NCT00549107)
- Testing
- Levosimendan, Milrinone
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Ludwig Boltzmann Gesellschaft
Fluid Overload
Furosemide Versus Ethacrynic Acid in Children With Congenital Heart Disease
This study aims to verify if ethacrynic acid continuous infusion is superior to furosemide continuous infusion in total urine output production during the first 24 post operative hours.
- Trial name
- NCT01628731
- Testing
- furosemide, ethacrynic acid
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Acute Coronary Syndrome, Cardiogenic Shock
Outcome of Patients Treated With IABP
Intra-Aortic Balloon Pumps (IABP) is a widely used and effective left ventricular adjuvant therapy. IABP is an inflatable device placed in the aorta that inflates with diastole and deflates with systole.
- Conditions
- Acute Coronary Syndrome, Cardiogenic Shock, Coronary Artery Disease, Heart Failure
- Trial name
- NCT04405856
- Testing
- Intra Aortic Balloon Pump
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing Medical University
Rhabdomyolysis Linked to a Hereditary Disease of Metabolism
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses
The prognosis of rhabdomyolyses related to hereditary diseases of metabolism is poor and treatments are only symptomatic. Rhabdomyolysis outbreaks are frequently precipitated by fever and fasting. They are unpredictable.
- Trial name
- EFFORHAB (NCT03802279)
- Testing
- Effort test, Functional tests on fibroblasts
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Heart Disease
NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery
Neonates and infants that have cardiac surgery with cardiopulmonary bypass (CPB) for congenital heart disease are at great risk for experiencing life-threatening low cardiac output syndrome (LCOS) in the first 24 hours after…
- Trial name
- NCT01849120
- Testing
- EQUANOX Advance 8004CB sensor
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Shock, Hypotension and Shock
ClearSight Validation in Pediatrics
Specific aim 1: The specific aim of this study is to compare cardiac output measurements as well as cardiac index, and stroke volume obtained via thermodilution during a cardiac catheterization with data obtained by the…
- Trial name
- NCT03701646
- Testing
- Measurement by Clearsight device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Fontan Procedure, Hypoplastic Left Heart Syndrome
Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques
The investigators are beginning a clinical research study here at UCSF to learn more about how hearts with single ventricles work.
- Conditions
- Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia, Double Inlet Left Ventricle
- Trial name
- NCT01107990
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Caudal Block
Effects Of Adjuvants to Caudal Anesthesia on Hemodynamics Measured By Electrical Cardiometry In Children
Caudal epidural anesthesia is one of the most common regional techniques used for post-operative pain management in pediatric patients.
- Trial name
- NCT03101137
- Testing
- Caudal block with dexmedetomedine, Caudal dexamethasone, Control (bupivacaine)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Hemodynamic Monitoring
Evaluation of the UltraTrac System as a Non-Invasive Monitor of Hemodynamic Parameters
This study will test the use of the UltraTrac™ system, a small, noninvasive device that uses electrodes on the skin and a small ultrasound sensor to provide measurements of cardiac function in a wide of subjects.
- Trial name
- NCT07862608
- Testing
- Noninvasive Hemodynamic Monitoring System
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- AcQumen Medical, Inc.