Clinical trials: Cardiac Perfusion
Chest Pain, Coronary Disease
MRI Evaluation of Chest Pain
This study will assess the value of magnetic resonance imaging (MRI) in detecting heart attack and heart attack risk in patients who come to the hospital emergency room because of chest pain.
- Conditions
- Chest Pain, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00001961
- Testing
- MRI
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Critical Congenital Heart Disease, High Altitude
Oxygen Saturation and Perfusion Index ın Neonates at High Altitude
Congenital heart diseases are among the most common congenital anomalies and occur with an incidence of approximately 8ınd12 / 1,000 live births worldwide.
- Trial name
- NCT04290481
- Testing
- oxygen saturation and perfusion index screening
- Where
- Turkey (Türkiye)
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Congenital Heart Disease
Evaluation of the Microcirculation During the Corrective Surgery of Congenital Heart Defects in Children
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
- Trial name
- NCT03144258
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Heart Disease, Cystic Fibrosis
Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease
The primary objective of this study is to determine if quantitative Dynamic contrast-enhanced magnetic resonance (DCE MR) perfusion imaging accurately quantifies right and left pulmonary artery blood flow as compared with phase…
- Conditions
- Heart Disease, Cystic Fibrosis, Asthma
- Trial name
- NCT01192360
- Testing
- Phase contrast flow velocity mapping (PC), Dynamic contrast-enhanced magnetic resonance imaging
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- The Hospital for Sick Children
Congenital Heart Disease
Improving Critical Congenital Heart Disease Screening With Addition of Perfusion Measurements
The purpose of this research is to evaluate and create a new clinical prediction model for CCHD screening that combines non-invasive measurements of oxygenation and perfusion.
- Trial name
- NCT04056104
- Testing
- SpO2 and PIx Measurement
- Where
- 6 sites in United States
- Volunteers
- 543 people
- Sponsor
- University of California, Davis
Congenital Heart Disease
Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
The purpose of this study is to implement and externally validate an inpatient ML algorithm that combines pulse oximetry features for critical congenital heart disease (CCHD) screening.
- Trial name
- NCT05637814
- Testing
- SpO2/PIx Measurement and ML Algorithm
- Where
- 3 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Congenital Heart Disease
NIRS Predict Low Cardiac Output State in Neonates and Infants in Cardiac Surgery
Neonates and infants that have cardiac surgery with cardiopulmonary bypass (CPB) for congenital heart disease are at great risk for experiencing life-threatening low cardiac output syndrome (LCOS) in the first 24 hours after…
- Trial name
- NCT01849120
- Testing
- EQUANOX Advance 8004CB sensor
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Heart Defects, Congenital
Quantification of Cerebral Perfusion by Contrast-enhanced Ultrasound During Neonatal Heart Surgery
Transcranial contrast-enhanced ultrasound for evaluation of cerebral blood flow during pediatric cardiac surgery. This study is aimed as a feasibility study prior to conducting a lager prospective clinical trial including…
- Trial name
- TCEUS (NCT03215628)
- Testing
- TCEUS
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Kawasaki Disease, Heart Disease
Real Time Myocardial Contrast Echocardiography and Dobutamine Stress Perfusion Magnetic Resonance Imaging
The present study is designed to: 1. investigate the safety and efficacy of Real time myocardial echocardiography (RT-MCE) in adolescents and adults ages 12-50 with congenital and acquired congenital heart disease 2.
- Trial name
- ECHOBIKE (NCT00861848)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Kangaroo-mother Care
Skin-to-skin Contact Between Premature Infant and Mother
Aim: To determine the effect of kangaroo mother care (KMC) on perfusion index, heart rate, and oxygen saturation in premature infants who were discharged early and admitted to the neonatal intensive care in the following days.
- Trial name
- NCT06380231
- Testing
- kangaroo mother care (KMC)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Istanbul Rumeli University
Coronary Artery Disease
Implication of Cardiac Shock Wave Therapy on Coronary Artery Disease Patients
CAD is a challenging affliction which has a high annual morbidity rate in China and the world. Severe CAD may lead to compromised cardiac function, decreased exertional capacity and poor quality of life (QOL).
- Trial name
- NCT04694157
- Testing
- cardiac shock wave therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Hospital
Cardiovascular Diseases, Coronary Arteriosclerosis
Myocardial Perfusion, Risk Factors, and Coronary Calcium
To determine whether an impairment of myocardial perfusion reserve is an early indicator of coronary artery disease.
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00006502
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease
Using Near-Infrared Spectroscopy Devices to Assess Myocardial and Visceral Perfusion During Complex Congenital Cardiac Surgery
The use of near infrared spectroscopy (NIRS) is a technique that has recently been incorporated by several other surgical specialties to measure tissue perfusion, such as in plastic surgery to allow for earlier detection of free…
- Trial name
- NCT07361523
- Testing
- Tissue oximeter (IntraOx)
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Kawasaki Disease, Cardiovascular Disease
Magnetic Resonance Myocardial Stress Perfusion in Pediatric Patients with Cardiovascular Disease
the goal of this observational study is to evaluate myocardial ischemia and myocardial microcirculation dysfunction in children with cardiovascular disease by myocardial stress perfusion imaging.
- Conditions
- Kawasaki Disease, Cardiovascular Disease, Anomalous Origin of Coronary Artery
- Trial name
- NCT06641843
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- West China Second University Hospital
ST Segment Elevation Myocardial Infarction, Coronary Slow Flow Phenomenon
Efficacy of Intracoronary Infusion of Different Medicine in STEMI Patients With CSFP
The study intends to evaluate the efficacy of different medicine delivering by targeted perfusion catheter in coronary administration on coronary blood flow in STEMI patients with CSFP.
- Trial name
- NCT03296670
- Testing
- Alprostadil, Nitroglycerin
- Where
- China
- Volunteers
- 57 people
- Sponsor
- RenJi Hospital
Congenital Heart Defects, Hypoplastic Left Heart Syndrome
Cerebral Perfusion During Neonatal Cardiac Surgery
Neonates with a congenital heart defect are often in need of early cardiac surgery. In complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (DHCA).
- Conditions
- Congenital Heart Defects, Hypoplastic Left Heart Syndrome, Aortic Coarctation
- Trial name
- NCT01032876
- Testing
- Deep Hypothermic Circulatory Arrest, Antegrade Cerebral Perfusion
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- UMC Utrecht
Hypotension (MeSH: D007022)
Carotid Artery Blood Flow, Blood Pressure, and Cardiac Output During Anesthesia in Children Aged 0-5 Years
Blood pressure is routinely monitored during anesthesia in children, but blood pressure alone may not accurately reflect blood flow to vital organs.
- Trial name
- CARFLOW (NCT07847203)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
NonST Elevation Myocardial Infarction
FAMOUS-NSTEMI MRI Sub-Study
BACKGROUND: Non-ST-segment elevation myocardial infarction (NSTEMI) is the commonest type of acute coronary syndrome (ACS) and has a poor long-term prognosis.
- Trial name
- NCT02073422
- Testing
- Fractional flow reserve, Magnetic resonance imaging
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- NHS National Waiting Times Centre Board