Clinical trials: Cardiovascular Condition
Leukemia, Lymphoma
Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor umbilical cord blood stem cell transplant helps stop the growth of cancer or abnormal cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00423826
- Testing
- Busulfan, Cytarabine, Fludarabine phosphate
- Where
- United States
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Lupus Erythematosus, Scleroderma
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
The aim of this project is to start a biological and clinical collection of patients presenting systemic autoimmune disease. This collection will provide appropriate biological samples to identify new biomarkers and to be…
- Conditions
- Lupus Erythematosus, Scleroderma, Myositis, Vasculitis
- Trial name
- ESSAi (NCT05251415)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Adverse Effect of MRI on an Implanted Pacemaker Lead, Adverse Effect of MRI on an Implanted Pacemaker
Safety and Efficacy of the Accent Magnetic Resonance Imaging™ (MRI) Pacemaker and Tendril MRI™ Lead
The MRI Study is a prospective, multi-center, clinical study designed to evaluate the safety and efficacy of the Accent MRI™ System in a patient population indicated for implant of a pacemaker within and outside of the MRI…
- Trial name
- NCT01576016
- Testing
- Accent MRI system (lead safety), Accent MRI system (with MRI scan)
- Where
- 70 sites in United States, Australia and 3 more
- Volunteers
- 950 people
- Sponsor
- Abbott Medical Devices
Diabetes, Gestational, Pregnancy Diabetic
Long-term Outcome After Gestational Diabetes and Diabetes in Pregnancy
The primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring.
- Trial name
- MuKiLOG (NCT04417452)
- Testing
- Basic data collection (online survey or written form), Physical examination, Psychometric examination
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease
Prognosis of Cerebral Small Vessel Disease
Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients…
- Conditions
- Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy
- Trial name
- PRO-SVD (NCT05734378)
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases, Heart Diseases
NAS-NRC Twin Registry
To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Ischemia
- Trial name
- NCT00005125
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Efficacy and Safety of Telmisartan and Losartan in Primary Hypertension
Using Losartan as a comparator, to evaluate the efficacy and safety of telmisartan in the treatment of the mild to moderate primary hypertension patients in China
- Trial name
- NCT02269176
- Testing
- Low dose of telmisartan, High dose of telmisartan, Low dose of losartan
- Volunteers
- 330 people
- Sponsor
- Boehringer Ingelheim
Cushing Syndrome
Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
This is an open-label extension study to evaluate the long-term safety of relacorilant in patients with endogenous Cushing syndrome who successfully completed participation in a Corcept-sponsored study of relacorilant and may…
- Trial name
- NCT03604198
- Testing
- relacorilant
- Where
- 48 sites in United States, Austria and 8 more
- Volunteers
- 125 people
- Sponsor
- Corcept Therapeutics
Congenital Heart Disease, Pulmonary Hypertension
Integrated Computational modelIng of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease
Advances in paediatric cardiology and cardiac surgery have enabled the survival of most patients born with congenital heart disease (CHD) into adulthood.
- Trial name
- NCT03217240
- Testing
- Cardiac Magnetic Resonance - MRI, Cardiopulmonary Exercise Test, Blood Sampling for all participants
- Where
- 3 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Aortic Coarctation, Erector Spinae Plane Block
Erector Spinae Plane Block Versus Fentanyl Infusion in Pediatric Patients Undergoing Aortic Coarcitectomy
Pain is considered to be subjective, however in children it is believed to be felt rather than expressed, because they often depend on the caregiver for their safety and well-being.
- Conditions
- Aortic Coarctation, Erector Spinae Plane Block, Paediatric
- Trial name
- NCT04128540
- Testing
- Fentanyl, Erector spinae plane block
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
Recently, intravitreal bevacizumab (Avastin) injection has gained popularity as a potential treatment of intraocular neovascularization (CNV) associated with age related macular degeneration and diabetic retinopathy.
- Trial name
- NCT00423059
- Testing
- bevacizumab
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Syncope, Pediatric
Pediatric Adhesion and New Dermal Approach Study
The purpose of this study is to see if the Zio® monitor device can be worn by children for up to 14-days and to determine if the skin preparation process will provide good adherence to the skin and clear signal quality.
- Conditions
- Syncope, Pediatric, Congenital Athymia, Congenital Heart Disease
- Trial name
- PANDA (NCT07118124)
- Testing
- Zio monitor
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- iRhythm Technologies, Inc.
Heart Failure
Ultrasound by Nurses in Heart Failure Patients
Cross-over study aimed to study the diagnostic and clinical impact of routinely adding a pocket-size ultrasound examination to traditional care at a outpatient heart failure clinic.
- Trial name
- NCT01794715
- Testing
- Ultrasound examination by nurses
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- Helse Nord-Trøndelag HF
Myocardial Ischemia, Heart Failure, Congestive
Stem Cell Therapy in Chronic Ischemic Heart Failure
The purpose of this study is to determine whether intracoronary bone marrow transplantation can improve left ventricular ejection fraction in patients with severe ischemic heart failure and no other option for standard therapies…
- Trial name
- NCT00235417
- Testing
- Bone marrow transplantation
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Odense University Hospital
Coagulation Defect; Bleeding
ROTEM Versus aPTT/PT in Pediatric Surgery
Hemocoagulation management in perioperative bleeding is nowadays based on standard coagulation testing: activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, D-dimers, platelets.
- Trial name
- NCT03699813
- Testing
- Comparison of two approaches to bleeding management
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Cerebral Palsy, Stroke
A Longitudinal Study of Motor Control and Brain Images in Patients With Brain Damage
The primary goal of this study is to establish and evaluate an image-based biomarker for the impaired motor control and sensory information processing present in Cerebral palsy (CP) and stroke patients.
- Trial name
- NCT01883960
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hypertension, Pulmonary
Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension
The TOPP-2 registry is an international, non-interventional, prospective registry including children and adolescents newly diagnosed with pulmonary hypertension (PH) to gain further insights in the disease course and long-term…
- Trial name
- TOPP-2 (NCT02610660)
- Where
- 32 sites in United States, Australia and 16 more
- Volunteers
- 388 people
- Sponsor
- Association for Pediatric Pulmonary Hypertension
Cardiovascular Diseases, Heart Diseases
Epidemiology of Insulin and Dehydroepiandrosterone Sulfate and Coronary Heart Disease Mortality
To determine whether serum insulin is a risk factor for coronary heart disease morbidity and mortality and whether dehydroepiandrosterone sulfate (DHEAS) is a risk factor for coronary heart disease mortality.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005246
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Shock, Hypotension and Shock
ClearSight Validation in Pediatrics
Specific aim 1: The specific aim of this study is to compare cardiac output measurements as well as cardiac index, and stroke volume obtained via thermodilution during a cardiac catheterization with data obtained by the…
- Trial name
- NCT03701646
- Testing
- Measurement by Clearsight device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Myocardial Bridge of Coronary Artery
Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges
To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal…
- Trial name
- NCT04082546
- Testing
- Surgical unroofing of muscle-briged coronary artery
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
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