Clinical trials: Caries; Initial
White Spot Lesion of Tooth, Long Term Adverse Effects
Comparison of Efficacy Of Probiotic Toothpaste and Chlorhexidine Mouthwash To Reduce S.Mutans
Orthodontic appliance causes increase in plaque accumulation, especially around brackets, wires and attachments. Advances in orthodontics in recent time have led to improved quality of appliance and treatment procedures…
- Conditions
- White Spot Lesion of Tooth, Long Term Adverse Effects, Caries, Dental, Orthodontic Appliance Complication
- Trial name
- NCT03004196
- Testing
- Probiotic Toothpaste, Dr. Reddy's Clohex, Control Group
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peoples University, Bhanpur, Bhopal
Dental Caries
Efficacy of Two Protocols for Applying Fluorine Varnish to Deciduous Teeth
Evidence that the data flow analysis tests, there are still no studies that show the clarity of the protocols of its application, including the interval and execution factors of applications, concentration of fluoridation and…
- Trial name
- CEPECO3 (NCT03827889)
- Testing
- WMP of fluoride varnish, TWLP of fluoride varnish, DHP (educational intervention)
- Where
- Brazil
- Volunteers
- 168 people
- Sponsor
- Universidade Ibirapuera
Caries,Dental
Correlation Between Caries Experience in Primary Molars and First Permanent Molars
A cross- sectional observational study which will investigate whether data of past caries experience of the primary molars of 6-9 years old children can serve as an indicator for caries development in first permanent molars.as…
- Trial name
- NCT03671200
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars
This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and…
- Trial name
- NCT07052526
- Testing
- Prevention, Prevention of caries, Prevention therapy
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Incipient Enamel Caries, Fissure, Dental
Retention of Bonded Amalgam Sealants Versus Resin-based Sealants
Dental caries, is one of the major public health problem in Pakistan. Dental sealants are known cost effective preventive measure of dental caries as compared to other preventive measures.
- Trial name
- NCT03130725
- Testing
- Amalgam sealant, Resin based sealant
- Where
- Pakistan
- Volunteers
- 51 people
- Sponsor
- Aga Khan University
Dental Caries
Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars
The aim of this study is to determine the effectiveness of fluoride varnishes in the prevention of dental caries lesions in erupting permanent first molars, in high-risk patients.
- Trial name
- NCT02592278
- Testing
- Fluoride Varnish, Control Group
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad Iberoamericana
Dental Caries in Children
Correlation Between Dental Caries Prevalence in Primary Teeth and First Permanent Moilar of Children in Mixed Dentition Stage
to find the clinical relation between caries experience in primary teeth and first permanent molar in mixed dentition stage using def index for primary teeth , DMF index for first permanent molars and to find the clinical…
- Trial name
- NCT04618731
- Testing
- caries prevalence def ,DMF
- Volunteers
- 1,000 people
- Sponsor
- Cairo University
Glass Ionomer Cement, Cost-effectiveness
Effectiveness and Economic Evaluation of Glass Ionomer Material Using as Dental Sealant
Eruption of the first permanent molar is the earliest in our oral cavity, leading to a high occurrence of dental caries in its pits and fissures.
- Conditions
- Glass Ionomer Cement, Cost-effectiveness, Pit and Fissure Caries (Disorder)
- Trial name
- NCT03034837
- Testing
- resin sealant, ART sealant
- Where
- 2 sites in China
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Zhengzhou University
White Spot Lesion of Tooth, Demineralization
Remineralization Potential of PRG Barrier Coat Versus Fluoride Varnish in White Spot Lesions in Permanent Anterior Teeth of Children
To evaluate the remineralization potential of PRG Barrier Coat versus fluoride varnish in white spot lesions in permanent anterior teeth of children.
- Trial name
- PRG Barrier (NCT06986551)
- Testing
- 5% NaF fluoride varnish, PRG Barrier coat
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Cairo University
White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
Remineralization Effect of βTricalcium Phosphate Nanoparticles Versus FunctionalizedβTricalcium Phosphate Nanoparticles
The study collects Sixty non carious sound human permanent premolars from Tanta University's maxillofacial surgery department. The teeth are cleaned and prepared, and randomly assigned into four groups.
- Trial name
- NCT06561789
- Testing
- Functionalized Nano ᵦ tricalcium phosphate particles, Nano ᵦ tricalcium phosphate particles, sodium fluoride mouth wash
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aya Magdy Elsadany
Dental Caries, Early Caries Lesion
Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children
Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression.
- Trial name
- OZONE-CARIES (NCT07671651)
- Testing
- Ozone Therapy, other
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Neslihan Atmaca
Initial Dental Caries, White Spot Lesion of Tooth
Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment
To evaluate and compare the clinical effect of four different remineralizing agents on initial enamel caries after a two years follow up.
- Trial name
- NCT07111403
- Testing
- SAP fluoride plus, 10% n-HAp., 10% n-BAG.
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Deep Caries, Molar Incisor Hypomineralisation
Comparison of Intraosseous Anaesthesia Using a Computerized System (QuickSleeper) to Conventional Anesthesia
The purpose is to compare the efficacy of an intraosseous anaesthesia using a computerized system (QuickSleeper) to a conventional infiltration anesthesia.
- Trial name
- QUICK (NCT02084433)
- Testing
- intraosseous anaesthesia using a computerized system, conventional anasthesia
- Where
- France
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Caries; Initial
Caries Inhibition With CO2-Laser During Orthodontic Treatment
The aim of the study is to assess the viability and efficacy of carbon dioxide laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed…
- Trial name
- NCT04903275
- Testing
- Topical fluoride application and Laser irradiation, Topical fluoride application
- Where
- 2 sites in Bulgaria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dental Caries
DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces
The purpose of this study was to document the reasons for placing the first restoration ("filling") on a previously un-restored surface in a permanent ("adult") tooth.
- Trial name
- NCT00847470
- Where
- 7 sites in United States, Denmark
- Volunteers
- 5,810 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Dental Caries, Dental White Spot
Effect of Light Curable Resin Modified Glass Ionomer Varnish on Non-Cavitated Proximal Carious Lesions' Progression
The standard-of-care preventive measures to stop early tooth decay from becoming worse is by fluoride application, diet counseling, and oral hygiene instructions. This standard way is not always successful.
- Trial name
- NCT03685058
- Testing
- Light curable resin modified glass ionomer varnish, standard-of-care preventive measures
- Where
- Saudi Arabia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Dental Caries in Children, Vital Pulp Therapy
Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study
The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity.
- Trial name
- NCT06372561
- Testing
- Mineral trioxide aggregate (dressing material), Melatonin (dressing material)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
White Spot Lesion of Tooth
Bioactive Glass in the Treatment of Enamel White Spot Lesions
the aim of this study is to evaluate the effectiveness of BiominF® and Novamin® in comparison to Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the treatment of enamel white spot lesions
- Trial name
- NCT04401280
- Testing
- BiominF, Novamin, CPP-ACP
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rania Salah
Dental Caries, Irreversible Pulpitis
Clinical and Radiographic Assessment of Photobiomodulated MTA Pulpotomy in Immature First Permanent Molars with Irreversible Pulpitis
This study evaluates the effectiveness of photobiomodulation (PBM) in conjunction with mineral trioxide aggregate (MTA) pulpotomy for treating irreversible pulpitis in immature first permanent molars.
- Trial name
- NCT06730360
- Testing
- MTA Pulpotomy without photobiomodulation, MTA Pulpotomy with Photobiomodulation (LLLT)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University