Clinical trials: Caries
Dental Caries, Oral Disease
Fluoride Varnish Community Trial
This cluster-randomized controlled community trial aimed to assess the efficacy and costs of fluoride varnish application for caries prevention in a high-risk population in South Africa.
- Conditions
- Dental Caries, Oral Disease, Costs
- Trial name
- NCT03429829
- Testing
- Flairesse varnish
- Where
- 2 sites in South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Caries Active, Prevention
Children in the Operating Room: Kids That go Thru Operating Room Will be Given a Connected Health Toothbrush, Kids Anticavity Toothpaste and Behavioral Health Intervention to Reduce Claim Costs
The objective of this study is to demonstrate that compliance and brushing adherence as a treatment to providers, insurance company and State Health Departments that can help improve oral health of children who have already been…
- Trial name
- NCT07539064
- Testing
- Connected Toothbrush with a behavioral health intervention
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Colgate Palmolive
Dental Caries
Safety and Performance Evaluation of the Calcivis System
This is a prospective, multi-centre clinical study to evaluate the safety and performance of the Calcivis Caries Activity Imaging System.
- Trial name
- NCT02780856
- Testing
- Imaging with the Calcivis System
- Where
- 4 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- Calcivis Ltd
Dental Caries
Effect of 12 Months Supplementation With a Symbiotic Lozenge on Caries Increment in Healthy Children
The primary objective of this trial is to investigate the effect of a symbiotic lozenge on dental caries in young children.
- Trial name
- PiP-C (NCT03928587)
- Testing
- 2 billion CFU in total of the two strains Lactobacillus paracasei subsp. paracasei and Lactobacillus rhamnosus and arginine.
- Where
- Denmark
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Dental Health, Caries
Efficacy of Proximal Caries Infiltration
The goal of the project is to investigate the clinical efficacy of management of early caries lesions by resin infiltration and to further scrutinize the patient stress experiences.
- Trial name
- NCT01726179
- Testing
- Resin infiltration, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Re-mineralization
Re-mineralization Effects of Sugar Free Chewing Gum Sweetened With Different Sugar-substitutes
The purpose of this study is to evaluate the clinical effect of chewing gum containing maltitol, on re-mineralization of early caries following daily chewing for 6 months by school children, compared to a xylitol gum, gum base…
- Trial name
- NCT02468388
- Testing
- maltitol, xylitol, gum base
- Where
- China
- Volunteers
- 482 people
- Sponsor
- Roquette Management (Shanghai) Co., Ltd.
Dental Caries
Comparison of Two GIC's in the Restoration of Posterior Class II Lesions in the Primary Dentition
This study will investigate the clinical performance of a novel restorative glass ionomer (DeltaFil, DMG) in comparison to an established restorative glass ionomer (Riva Self Cure HV, SDI) in the restoration of Class II cavities…
- Trial name
- NCT05965297
- Testing
- DeltaFil, Riva Self Cure HV
- Where
- 2 sites in Brazil, Portugal
- Volunteers
- 140 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Enamel Lesions, Caries
Enamel Lesion Detection With New DX Tool
The primary objective of this 12-week study is to test BlueCheck's ability to identify enamel lesions consistently, and its ability to track changes in these lesions over time.
- Trial name
- NCT07819370
- Testing
- BlueCheck, Prevident 5000ppm Booster Plus Toothpaste
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Colgate Palmolive
Dental Caries
Efficacy Of A PVP-I Fluoride Varnish
The purpose of the study is to determine the efficacy of Advantage Anti-Caries Varnish. Single-center, double-blind, controlled Phase 2 study with parallel groups of children.
- Trial name
- NCT03082196
- Testing
- Test varnish, Standard varnish
- Where
- Micronesia
- Volunteers
- 284 people
- Sponsor
- Advantage Dental Services, LLC
Dental Caries in Children
Comparison of Early Caries Detection in Children Utilizing an Electrical Conductance Device and the Gold Standard of Visual-tactile Technique.
The purpose of this study is to evaluate a methodology for detecting early forming cavities in children that is more accurate and reliable than the gold standard used by dentists around the world.
- Trial name
- NCT02002728
- Where
- Venezuela
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ortek Therapeutics, Inc.
Dental Caries
Comparative Study of Experimental Dental Adhesive With and Without Phosphoric Acid Pretreatment
The intent of this study is to evaluate the clinical performance of an experimental dental bonding agent for use with dental restorative composites with and without pretreatment of the tooth dentin and enamel using phosphoric…
- Trial name
- NCT02071953
- Testing
- Experimental adhesive w/out phosphoric acid in post. rest., Experimental adhesive with phosphoric acid in post. rest.
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Sequential PVP-I and FV
This prospective cohort study in children will determine if: topical povidone iodine 10% followed by topical fluoride varnish is superior to placebo iodine followed two different varnishes alone to prevent tooth decay (dental…
- Trial name
- NCT07683910
- Testing
- fluoride varnish, 2.5%, topical fluoride, 2.1%, Povidone Iodine Topical
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
A Phase 2 Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Varnish and Strip in Adolescent and Adult Subjects
An open-label and single-blind phase 2 study to evaluate the oral microbiology, safety and tolerability of multiple C16G2 Varnish and Strip applications in male and female dental subjects 12-75 years of age.
- Trial name
- C3J17-206-00 (NCT03196219)
- Testing
- C16G2
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Caries Infiltration, Fluorosis
Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Dental fluorosis is a clinical manifestation of chronic exposure to high intakes of fluoride during the tooth development. The present study is planned to evaluate the efficacy of Resin Infiltration technique in improving the…
- Conditions
- Caries Infiltration, Fluorosis, Dental Care
- Trial name
- NCT01733888
- Testing
- Office Bleaching, Resin Infiltration, Resin Infiltration twice
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries, Pulp Exposure, Dental
Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure
This research study is looking at the safety and effectiveness of Solventum™ Vitrebond™ Pulp Protect Liner/Base for direct pulp capping (DPC) on permanent teeth that have pulp exposure due either to deep cavities, trauma, or…
- Conditions
- Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
- Trial name
- NCT07231237
- Testing
- Vitrebond™ Pulp Protect Liner/Base
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Dental Caries
Effects of a Hydroxyapatite-based Mouth Gel on Calcium Content of Plaque
The aim of this pilot study is to analyze if a hydroxyapatite-containing mouth gel has an influence on the calcium content of plaque.
- Trial name
- NCT03956992
- Testing
- Mouth gel
- Where
- Indonesia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Dental Caries
Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control…
- Trial name
- NCT07241052
- Testing
- oral-spray 0.9% NaCl physiological saline solution, Smile Care
- Where
- Vietnam
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Dental Caries
Post-Approval Clinical Study to Evaluate the Calcivis Caries Activity Imaging System
This is a prospective, multi-centre, post-approval clinical study to assess the safety and the performance of the Calcivis Caries Activity Imaging System in aiding the identification of active caries lesions on the occlusal…
- Trial name
- NCT02098304
- Testing
- Calcivis Caries Activity Imaging System
- Where
- 3 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- Calcivis Ltd