Clinical trials: Cartilage Lesion
Cartilage Diseases
Autologous Cell-derived Tissue Engineered Cartilage for Repairing Articular Cartilage Lesions
This study is aimed at evaluating the feasibility and effectiveness of a completely natural tissue engineered cartilage, composed of a self-made tissue engineered oriented scaffold and autologous chondrocytes, for repairing…
- Trial name
- NCT02770209
- Testing
- biomimetic cartilage matrix + autologous chondrocytes, arthroscopic debridement, microfracture surgery
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Cartilage Damage, Osteochondral Lesion
Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation
The aim of our study is to add to the literature the effect of the effectiveness of the physiotherapy and rehabilitation in the clinic, which will be applied to the patients after the osteochondral allograft transplantation…
- Conditions
- Cartilage Damage, Osteochondral Lesion, Allograft, Osteoarthritis of Knee
- Trial name
- NCT06644092
- Testing
- Investigation of the Effectiveness of Physiotherapy and Rehabilitation After Osteochondral Allograft Transplantation Operation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Yeditepe University
Chondral or Osteochondral Lesion of Medial Femoral Condyle, Chondral or Osteochondral Lesion of Lateral Femoral Condyle
BiPhasic Cartilage Repair Implant (BiCRI) IDE Clinical Trial - Taiwan
The purpose of this trial is to evaluate the safety and effectiveness of the Biphasic Cartilage Repair Implant (BiCRI) compared to marrow stimulation in the treatment of chondral and osteochondral lesions located on the medial…
- Conditions
- Chondral or Osteochondral Lesion of Medial Femoral Condyle, Chondral or Osteochondral Lesion of Lateral Femoral Condyle, Chondral or Osteochondral Lesion of Trochlea
- Trial name
- NCT01477008
- Testing
- BiPhasic Cartilage Repair Implant, Marrow Stimulation
- Where
- 11 sites in Taiwan
- Volunteers
- 92 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Trachea Diseases, Tracheal Stenosis
Feasibility of Tracheobronchial Reconstruction Using Allogenic Aortic Patch in Children
Feasibility and safety of repairing tracheal and bronchial defects in infants and children using cryopreserved donor aortic patches.
- Conditions
- Trachea Diseases, Tracheal Stenosis, Tuberculosis; Tracheitis, Airway Disease
- Trial name
- NCT07240259
- Testing
- Cryopreserved aorta
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Chondral Defect, Articular Cartilage Defect
A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle
The objective of this study is to demonstrate the superiority of MACI (autologous cultured chondrocytes on porcine collagen membrane) versus Bone Marrow Stimulation in the treatment of patients aged 17 to 65 years with…
- Trial name
- MASCOT (NCT06915233)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
- Where
- 9 sites in United States
- Volunteers
- 309 people
- Sponsor
- Vericel Corporation
Articular Cartilage Disorder of Knee
The Clinical Outcome of BiCRI in the Treatment of Chondral and Osteochondral Lesions
Based on the previous successful experiences, the investigators like to extend our patient population. In this study, the investigators aim to determine the safety and effectiveness of the Biphasic Cartilage Repair Implant…
- Trial name
- NCT05924763
- Testing
- Biphasic Cartilage Repair Implant (BiCRI)
- Where
- 2 sites in Taiwan
- Volunteers
- 11 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Osteochondral Lesion of Talus, Degenerative Lesion of Articular Cartilage of Knee
Clinical and Radiological Results of Osteochondral Repair Using MaioRegen in Knee and Ankle Surgery
Osteochondral lesions in knee and ankle are injuries commonly seen in young patients. MaioRegen fleece is a cartilage substitute which can be used in circumscribed defects.
- Trial name
- NCT02345564
- Testing
- implantation of MaioRegen fleece into osteochondral lesion
- Volunteers
- 15 people
- Sponsor
- Barmherzige Brüder Eisenstadt
Cartilage Injury, Orthopedic Disorder
CAsting and REhabilitation Versus Supervised Neglect for Osteochondral Lesions of the Talus in the Pediatric Population
Rationale: OCLs (osteochondral lesions) of the talus can be congenital or can occur after trauma or in patients with juvenile idiopathic arthritis (JIA). The main complaint of an OCL is pain during weightbearing activities.
- Conditions
- Cartilage Injury, Orthopedic Disorder, Skeletal Injury, Rehabilitation
- Trial name
- CARE (NCT06220539)
- Testing
- Casting and supervised rehabilitation
- Where
- 2 sites in Netherlands
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tristan Buck
Osteochondritis
"One-step" Bone Marrow Mononuclear Cell Transplantation in Talar Osteochondral Lesions
BACKGROUND Osteochondral lesions are defects of the cartilaginous surface and underlying subchondral bone of the talar dome. The use of concentrated bone marrow derived cells has been gaining successful results with arthroscopic…
- Trial name
- BMDC (NCT02005861)
- Testing
- bone marrow cells transplantation on collagen scaffold
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Istituto Ortopedico Rizzoli
ACL Injury, Meniscus Lesion
Muscle Function and Traumatic Knee Injury in Sports
The aims of the project are to 1) evaluate different aspects of muscle function and its role as a potential risk and/or protective factor for traumatic knee injury in youth female athletes; 2) develop and evaluate a battery of…
- Conditions
- ACL Injury, Meniscus Lesion, Cartilage Injury, Ligament Injury
- Trial name
- NCT03479775
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Osteochondral Defect of Talus
Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autologous Matrix-induced Chondrogenesis (AMIC)
This clinical study evaluates the long-term, ten-year clinical and functional outcomes of patients who underwent arthroscopic repair of osteochondral lesions of the talus (OLT) using the autologous matrix-induced chondrogenesis…
- Trial name
- AMIC10Y (NCT07725770)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Cartilage Damage
This is a Study to Evaluate Nanofractures Technique in the Treatment of Cartilage Lesions
Articular cartilage lesions, with their inherent limited healing potential, remain a challenging problem for orthopaedic surgeons.
- Trial name
- NCT05660161
- Testing
- Nanofracture
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Cartilage Injury, Cartilage Damage
ProChondrix® CR Articular Cartilage Restoration Evaluation (PACE) Registry
The primary objective of this registry is to obtain long-term outcomes on ProChondrix CR in cartilage repair procedures of the knee, ankle, foot and hip.
- Trial name
- NCT04301258
- Testing
- Articular cartilage repair
- Where
- 5 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AlloSource