Clinical trials: Case-Control Studies
Polycystic Ovary Syndrome, Preterm Birth
Metabolic and Endocrine Status in Women With Prior Preterm Birth
The prevalence of preterm birth is rising in most western countries. The causes of preterm birth is not fully understood and seem to be multifactorial.
- Conditions
- Polycystic Ovary Syndrome, Preterm Birth, Diabetes Mellitus
- Trial name
- NCT01355536
- Where
- Norway
- Volunteers
- 262 people
- Sponsor
- Namsos Hospital
Childhood Cancer
Pain, Body Composition and Physical Activity in Childhood Cancer.
Comparing baseline assessments of children with cancer and their parents with baseline assessments of healthy children and their parents in a case-control study will allow the investigators to make the comparison in terms of…
- Trial name
- NCT04004455
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Psychotic Episode
Evaluation of the Impact of Case Manager Intervention on the 3-year Psychotic Episode Recurrence Rate in Patients Aged 16 to 30 Years With a First Psychotic Episode.
The study investigators hypothesize that the intervention of case managers specifically trained in case management of early psychosis will change the paradigm of care of a first psychotic episode from the current organization of…
- Trial name
- PEPsy-CM (NCT05116514)
- Testing
- Case management
- Where
- 6 sites in France
- Volunteers
- 256 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Epileptic Seizures Related to Drugs, SARS-CoV-2 Acute Respiratory Disease
Epileptic Seizure in Epilepsy Patients After SARS-CoV-2 Vaccination
Background and Objectives: Seizure attack is one of adverse effects of vaccination in epileptic patients, the risk of which after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculation was elucidated in the…
- Conditions
- Epileptic Seizures Related to Drugs, SARS-CoV-2 Acute Respiratory Disease, Vaccine Adverse Reaction
- Trial name
- NCT05341713
- Testing
- inactive SARS-Cov-2 vaccine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Xijing Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
Genetic Risk Score of Type 1 Diabetes Mellitus for Progression to Insulin in Diabetic Patients Lack of Predictive Value: a Multicenter Nested Case-control Study
The goal of this observational study is to evaluate the predictive value of the genetic risk score for type 1 diabetes in the progression to insulin deficiency in diabetic patients. The main question it aims to answer is: 1.
- Trial name
- NCT07621445
- Where
- China
- Volunteers
- 2,950 people
- Sponsor
- Second Xiangya Hospital of Central South University
Anorexia Nervosa
Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)
The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors.
- Trial name
- CoCA (NCT02381639)
- Testing
- One interview of 90 minutes with a part of cognitive assessment and a part of self-assessment
- Where
- France
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Arrhythmias, Cardiac
Evaluating the Risk of Serious Ventricular Arrhythmia and Sudden Cardiac Death Among Users of Domperidone
The purpose of this retrospective observational study is to obtain information to confirm or contradict the results of prior studies on domperidone and sudden cardiac death.
- Trial name
- NCT00925457
- Testing
- No Intervention, Current Domperidone, Current proton pump inhibitor (PPI)
- Volunteers
- 1,608 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acetaminophen, Drug-Induced Liver Injury
Screening of Susceptibility Genes for APAP Induced Drug Induced LIver Injury in ChiNese Population: a Case-control Study
Acetaminophen (APAP) is the most commonly used NSAIDS in clinic, and it is also a common cause of drug-induced liver injury (DILI).
- Conditions
- Acetaminophen, Drug-Induced Liver Injury, Pharmacogenetics, China
- Trial name
- PAIN (NCT04964310)
- Testing
- genetic polymorphism
- Where
- China
- Volunteers
- 339 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Coronary Artery Disease
A Case-control Study to Assess the Association Between Facial Characteristics and Coronary Artery Diseases
The purpose of this study is to explore the facial characteristics associated with the increased risk of coronary artery diseases.
- Trial name
- NCT03214783
- Testing
- Facial characteristics
- Where
- China
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Aplastic Anemia
Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia
To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls.
- Trial name
- MCSAA (NCT03208647)
- Testing
- AA or not
- Volunteers
- 1,802 people, healthy volunteers welcome
- Sponsor
- Shengyun Lin
Polyps
Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal Adenomas
Little is known about the prevalence of small bowel polyps in patients with sporadic Duodenal/Ampullary polyps. The investigators aim to investigate the prevalence of small bowel polyps in patients with sporadic (ie not related…
- Trial name
- SPIDA (NCT02470416)
- Testing
- Small bowel video capsule endoscopy (VCE) GIVEN/COVIDIEN LTD
- Where
- Australia
- Volunteers
- 177 people
- Sponsor
- Western Sydney Local Health District
Esophageal Squamous Cell Carcinoma
A Pilot for a Case-Control Study of Esophageal Squamous Cell Carcinoma in Western Kenya
Background: Esophageal cancer is the sixth leading cause of cancer deaths worldwide. Two primary cell types, squamous cell carcinoma and adenocarcinoma, account for most cases.
- Trial name
- NCT00901173
- Where
- Kenya
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cysticercosis, Helminthiasis
Taenia Solium Control Case Study in Zambia
Summary Diseases due to T. solium and soil transmitted helminths (STHs) are of cosmopolitan distribution and strongly linked with poor sanitation and poverty.
- Trial name
- SANTOSOIL (NCT01368354)
- Testing
- CLTS
- Where
- Zambia
- Volunteers
- 1,197 people
- Sponsor
- University of Zambia
Diarrhea Infantile
Phenotype and Multi-omics Analysis of Children With Congenital Diarrhea and Enteropathy in China
This study will establish a clinical cohort of children with congenital diarrhea and enteropathy (CODE), mine biomarkers of CODE through multi-omics technology and construct a clinical risk prediction model.
- Trial name
- NCT06356545
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Cardiovascular Diseases
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
Bicuspid aortic valve (BAV) is the most common congenital heart anomaly in the general population (1-2% of all individuals). In affected people, the aortic valve (the structure ensuring one way blood flow between the heart's left…
- Trial name
- BRAVE (NCT04514445)
- Testing
- Observational
- Where
- 4 sites in United Kingdom
- Volunteers
- 700 people
- Sponsor
- University Hospitals, Leicester
Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature
Building a Computational Model of Auditory Hallucinations
Some people hear voices or sounds that other people cannot hear; these are called auditory hallucinations. The study aims to understand what is happening in the brain when this occurs and will use brain scans to learn more.
- Conditions
- Schizophrenia / Schizoaffective Disorder, Schizophrenia and Disorders With Psychotic Feature, Psychosis, SCHIZOPHRENIA 1 (Disorder)
- Trial name
- CLARITY WP1 (NCT07820553)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- King's College London
Disc Degeneration
Lumbar Spine on MRI and Low Back Pain in Elite Cross-country Skiers
The investigators will examine the prevalence of low-back pain and disc degeneration among Finnish elite skiers between 16 and 35 years of age and compare these findings with the data collected among healthy volunteers studied…
- Trial name
- NCT05641857
- Where
- Finland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Orton Orthopaedic Hospital
Pure Red-cell Aplasia
A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa
The purpose of this study is to collect historical occurrences of risk factors that are potentially associated with the development of anti-erythropoietin (EPO) antibody positive pure red cell aplasia (PRCA) in participants with…
- Trial name
- NCT00211068
- Testing
- No intervention
- Where
- 22 sites in Brazil, France and 5 more
- Volunteers
- 124 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Gastric Cancer
Gastric Cancer Early Detection by Multi-dimensional Analysis of cfDNA
To facilitate the early gastric cancer diagnosis, an assay based on assessing large-scale methylation and fragmentation profiles of the plasma cell free (cfDNA) will be developed and validated.
- Trial name
- NCT05668910
- Testing
- whole genomic methylation and fragmentation profile analysis of cfDNA
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- GeneCast Biotechnology Co., Ltd.
Streptococcus Agalactiae Infection
Development of a Serocorrelate of Protection Against Invasive Group B Streptococcus Disease
A multicentre study to provide evidence that the relationship between an immune marker value (anti-GBS IgG concentration) and the probability of invasive GBS (iGBS) disease in infants less than 90 days of age is sufficiently…
- Trial name
- iGBS3 (NCT04735419)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- St George's, University of London