Clinical trials: Central Nervous Injury
Insomnia, Traumatic Brain Injury
Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (mTBI).
- Trial name
- NCT03261674
- Testing
- CBT-I, ABT-I
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in Traumatic Brain Injury
The overall goal of Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker…
- Trial name
- TRACK-TBI (NCT02119182)
- Testing
- In-Person Outcome Assessment, Phone Outcome Assessment, 3T Magnetic Resonance Imaging (MRI)
- Where
- 23 sites in United States
- Volunteers
- 2,996 people
- Sponsor
- University of California, San Francisco
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Electromyography
Electromyographic Biofeedback and Physical Therapy in Upper Limb Hemiparesis
The aim of this study was to assess the effect of a specific protocol of sEMG-BFB in upper limb hemiparesis added to conventional physical therapy on changes in upper extremity functionality, motor recruitment pattern and range…
- Trial name
- EMG-BFB (NCT02974465)
- Testing
- Biofeedback Electromyography, Conventional Physical Therapy Treatment
- Volunteers
- 40 people
- Sponsor
- University of Alcala
Mild Traumatic Brain Injury
Pro-2-Cool Device Clinical Study
This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling when applied up to 8 days after mild traumatic brain injury (mTBI) among adolescents participating in sporting activities.
- Trial name
- NCT03511339
- Testing
- TecTraum device
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- TecTraum Inc.
Safety Issues, Effect of Drugs
The Treatment of Premature Infants With Brain Injury by Autologous Umbilical Cord Blood Stem Cells
To study the safety and effect of autologous umbilical cord blood stem cells for treatment brain injury
- Trial name
- NCT03696745
- Testing
- autologous umbilical cord blood stem cells, 0.9% Sodium-chloride
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation
Traumatic Brain Injury, Children
Intranasal Dexmedetomidine Sedation for Pediatric CT Imaging
This study has the objective to determine if intranasal dexmedetomidine, a sedative, is suitable for pediatric sedation in children undergoing tomographic scans.
- Trial name
- NCT01900405
- Testing
- Dexmedetomidine
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Cerebral Palsy, Brain Injury
Validation of a 3D Instrumented Serious Game to Evaluate Upper Limb Impairments in Children With Neuromotor Disorders
The goal of this clinical trial is to validate an instrumented 3D serious game to assess upper limb impairments in children with neuromotor disorders.
- Conditions
- Cerebral Palsy, Brain Injury, Neurological; Disorder, Nervous System
- Trial name
- Play2BEAPI (NCT06774456)
- Testing
- instrumented 3D serious game (BE API 3.0)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Head Injury, Intracerebral Hemorrhage
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
- Conditions
- Head Injury, Intracerebral Hemorrhage, Ischemic Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT00886054
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Parkinson Disease, Dystonia
Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia
This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.
- Conditions
- Parkinson Disease, Dystonia, Autonomic Dysreflexia
- Trial name
- NCT03307161
- Testing
- osteopathic manual therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Spinal Cord Injury
Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation
Many people with spinal cord injury are no longer able to walk and must use wheelchairs for mobility. These individuals experience greater rates of depression and lower quality of life.
- Trial name
- NCT02104622
- Testing
- ReWalk Rehabilitation 2.0
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury
As functional electrical stimulations has evident role in improving motor control in tenodesis function (power and precision grip) but its results are considered to be short term so addition of task oriented approach i.e.
- Trial name
- NCT05411692
- Testing
- Functional electrical stimulations and motor priming exercise, Functional electrical stimulations, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Cerebral Hemorrhage
Retrospective Study on the Direction of Artificial Intelligence in Identifying Cranial Trauma CT Imaging
The goal of this observational retrospective study is to evaluate artificial intelligences (AI)'s proficiency in identifying and annotating brain bleeds in computed tomography (CT) images.
- Trial name
- NCT06230419
- Where
- China
- Volunteers
- 208 people
- Sponsor
- RenJi Hospital
Brain Damage, Cerebral Palsy
Efficacy of Modified Constraint-induced Movement Therapy in Children With Brain Damage
This research centers on the comparison of the immediate efficacy (right after therapy) and the maintained efficacy (3 months and 6 months) between "Modified Constraint-Induced Movement Therapy" (mCIMT) group and control group at…
- Conditions
- Brain Damage, Cerebral Palsy, Traumatic Brain Damage
- Trial name
- NCT01076257
- Testing
- Modified Constraint-induced Movement Therapy
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injuries, Orthostatic Hypotension
Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI
This study seeks to evaluate whether the speed (cadence) of lower extremity robotic movement has an impact on orthostatic hypotension and upright tolerance when training with the ErigoPro robotic tilt-stepper.
- Trial name
- NCT04029974
- Testing
- ErigoPro
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Methodist Rehabilitation Center
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