Clinical trials: Central Nervous System Inflammation
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Atherosclerosis, Carotid Atherosclerosis
Visualization of Carotid Atherosclerosis by 68Ga-MSA
Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the…
- Conditions
- Atherosclerosis, Carotid Atherosclerosis, Noninvasive Imaging of Atherosclerosis
- Trial name
- NCT01893489
- Testing
- 68Gallium-MSA
- Where
- 2 sites in South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Korea University
Meningitis, Meningococcal, Meningococcal Sepsis
Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.
A fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. A fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease.
- Conditions
- Meningitis, Meningococcal, Meningococcal Sepsis, Meningococcal Disease, Meningococcal Infections
- Trial name
- PIC (NCT03378258)
- Where
- United Kingdom
- Volunteers
- 1,329 people
- Sponsor
- Belfast Health and Social Care Trust
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Streptococcus Pneumonia, Streptococcus Pyogenes Infection
Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection
As Covid 19 manifestations that have been recently described, inflammatory manifestation have major impact in infectious disease lesions.
- Conditions
- Streptococcus Pneumonia, Streptococcus Pyogenes Infection, Neisseria Meningitides Meningitis
- Trial name
- RIPI (NCT04594785)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Encephalitis, Central Nervous System Infections and Inflammations
Brazil ICU Encephalitis Surveillance
Our proposal is to develop a sentinel syndromic surveillance strategy to identify encephalitis cases possibly related to emerging pathogens admitted to ICUs in Brazil.
- Conditions
- Encephalitis, Central Nervous System Infections and Inflammations, Intensive Care Neurological Disorder, Prognosis
- Trial name
- NCT05370573
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 451 people
- Sponsor
- D'Or Institute for Research and Education
Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia
Pediatric Arthropathy Beyond Inflammation: Clinical Spectrum and Diagnostic Approach at Assiut University Children Hospital
To identify the most common underlying causes of non-inflammatory arthropathy in children presenting to Assiut University Children Hospital for through clinical evaluation, laboratory testing, and imaging, in order to improve…
- Conditions
- Mucopolysaccharidoses, Progressive Pseudorheumatoid Dysplasia, Farber Disease, Osteogenesis Imperfecta
- Trial name
- NCT07173010
- Volunteers
- 35 people
- Sponsor
- Assiut University
Encephalitis
Investigating the Role of Early Intravenous Immunoglobulin Treatment for Children With Encephalitis
This is a phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the treatment of children with encephalitis.
- Trial name
- IgNiTE (NCT02308982)
- Testing
- Immunoglobulins, Intravenous (Privigen)
- Where
- 25 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Oxford
Cerebral Palsy, Spastic
Muscle-tendon Pathology and Metabolic Dysregulation in CP
The main aim of this project is to gain knowledge about the muscle-tendon pathology of moderately to severely affected young people with cerebral palsy and their risk for cardiometabolic diseases and chronic inflammation.
- Trial name
- NCT06330922
- Testing
- Cardiorespiratory fitness training
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Graz
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Concussion, Brain, Treatment
Modulating Exercise Dosage to Improve Concussion Recovery
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects…
- Conditions
- Concussion, Brain, Treatment, Aerobic Exercise, Inflammation
- Trial name
- MEDIC (NCT05434130)
- Testing
- High Dose Exercise
- Where
- 3 sites in United States
- Volunteers
- 178 people
- Sponsor
- University of Colorado, Denver
Pediatric Cancer, CNS Tumor, Childhood
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.
- Conditions
- Pediatric Cancer, CNS Tumor, Childhood, Skin Inflammation
- Trial name
- NCT04479514
- Testing
- Warm Baths or Showers, Moisturizer, SPF 30 or Higher Suncreen
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dana-Farber Cancer Institute
Neonatal Seizure, Epilepsy
Evaluating the Role of Inflammation in Neonatal Epileptogenesis
The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.
- Conditions
- Neonatal Seizure, Epilepsy, Seizures, Inflammatory Response
- Trial name
- NSR-RISE (NCT04259125)
- Testing
- Blood draw, Survey
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Francisco
Brain Disease
Inflammatory and Infectious Diseases of the Nervous System
Background: Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this.
- Trial name
- NCT02435810
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Listeriosis, Pregnancy Complications
National Study on Listeriosis and Listeria
Listeriosis is a foodborne infection responsible for severe disease. Three main forms are described: septicaemia, central nervous system infections and maternal-fetal infections.
- Conditions
- Listeriosis, Pregnancy Complications, Infectious, Central Nervous System Infections
- Trial name
- MONALISA (NCT01520597)
- Where
- France
- Volunteers
- 2,132 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Risk Factor, Cardiovascular Diseases
Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Dietary Approaches to Stop Hypertension (DASH) diet, a dietary pattern that emphasizes fruits and…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Coronary Heart Disease, Stroke
- Trial name
- NCT03542370
- Testing
- DASH dietary pattern
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Adrenoleukodystrophy, Adrenomyeloneuropathy
Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia
This study is a national, non-randomized, open-label, multi-site with minimal risk study in adult with adrenomyeloneuropathy (AMN), childhood and adult subjects with cerebral ALD (cALD), juvenile/adult metachromatic…
- Conditions
- Adrenoleukodystrophy, Adrenomyeloneuropathy, Metachromatic Leukodystrophy, Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia
- Trial name
- MATRIX (NCT04925349)
- Testing
- Blood sample collection
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ataxia Telangiectasia
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT02285348
- Testing
- Lumbar puncture
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Urea Cycle Disorders
Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders
The primary purpose of the proposed study is to characterize the oxidative stress and inflammatory cytokine status in UCD during baseline and decompensated states.
- Trial name
- NCT01541722
- Where
- 11 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- Mark Batshaw