Clinical trials: Central Nervous System Inflammation
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Pain, Inflammation
UVB Model Validation Study
Single centre, subject and observer blinded, placebo controlled, cross-over study of the effect of oral ibuprofen and topical hydrocortisone-21-acetate on ultraviolet radiation (UVR) induced pain and inflammation in healthy…
- Conditions
- Pain, Inflammation, Healthy Volunteers
- Trial name
- NCT01055249
- Testing
- Ibuprofen, Hydrocortisone, Hydrocortisone
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- X-pert Med GmbH
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Spinal Cord Injury, Chronic Inflammation
Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors…
- Conditions
- Spinal Cord Injury, Chronic Inflammation, Glucose Metabolism, Endothelial Function
- Trial name
- SCIPHS (NCT04971408)
- Testing
- passive heat stress, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Atherosclerosis, Carotid Atherosclerosis
Visualization of Carotid Atherosclerosis by 68Ga-MSA
Until now, no specific atherosclerosis-targeting agent labeled with positron emitter is not yet available. Investigators developed neomannosyl human serum albumin(MSA) for the terminal mannose residues of MSA binding with the…
- Conditions
- Atherosclerosis, Carotid Atherosclerosis, Noninvasive Imaging of Atherosclerosis
- Trial name
- NCT01893489
- Testing
- 68Gallium-MSA
- Where
- 2 sites in South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Korea University
Vascular Disease, Vascular Disease Risk
Effect of Atorvastatin (Lipitor) on Gene Expression in People With Vascular Disease
This study will determine if the drug Atorvastatin (Lipitor) changes the genetic material found in blood cells of people with vascular (blood vessel) disease.
- Trial name
- NCT00293748
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage, Brain Hematoma
Microplastics in Brain Hematomas and Neurological Outcomes After Intracerebral Hemorrhage
This observational study investigates the presence of micro- and nanoplastics in surgically removed intracerebral hematomas and their association with neurological outcomes in patients with spontaneous intracerebral hemorrhage.
- Trial name
- PARTENOPE (NCT07580326)
- Testing
- Observational Analysis
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Gaucher Disease Type 1
Role of Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)
The purpose of this study is to measure levels of blood and brain chemicals related to oxidative stress and inflammation in healthy volunteers and individuals with Type 1 Gaucher disease (GD1) to see if these levels are altered…
- Trial name
- NCT02583672
- Testing
- N-acetylcysteine
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Epilepsy
Exploring the Effects of Genetic Variants and Inflammation on Vitamins Supplementation Treatment Outcomes in Epilepsy
The management of patients with epilepsy is focused on controlling seizures, avoiding treatment side effects, and restoring quality of life.
- Trial name
- NCT04488172
- Testing
- Multi-vitamin supplementation
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Traumatic Brain Injury
Co-ultra PEALut Enhances Neuronal Recovery Following Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) typically provokes secondary injury mechanisms, including the dynamic interplay between the ischemic, inflammatory, and cytotoxic processes.
- Trial name
- GLIA13 (NCT03818451)
- Testing
- Co-ultraPEALut (Glialia)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Messina
Alzheimer Disease
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD.
- Trial name
- NCT04740580
- Testing
- Glycine, N-acetylcysteine, Alanine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Central Nervous System (CNS) Lesions, Brain Metastases
Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent
This Phase 2 clinical trial will study RVP-001, a new manganese-based MRI contrast agent, in people who are known to have gadolinium-enhancing central nervous system (CNS) lesions, for example brain tumors or multiple sclerosis.
- Conditions
- Central Nervous System (CNS) Lesions, Brain Metastases, Brain Neoplasms, Brain Neoplasms, Benign
- Trial name
- NCT06322342
- Testing
- RVP-001
- Where
- 5 sites in United States
- Volunteers
- 18 people
- Sponsor
- Reveal Pharmaceuticals Inc.
Alzheimers Disease
A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease
The study is being conducted to understand how the medicine, semaglutide, affects the immune system and other biological processes in people with Alzheimer's disease.
- Trial name
- NCT05891496
- Testing
- Semaglutide
- Where
- 12 sites in United States, Canada and 4 more
- Volunteers
- 23 people
- Sponsor
- Novo Nordisk A/S
Memory Disorders, Alzheimer's Disease
Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
In this phase I-II parallel design, randomized, double-blind clinical trial we will determine if 3,000 or 30,000 units ingested hrIFN-a prevents deterioration of cognitive functioning in patients with dementia of Alzheimer's type…
- Trial name
- NCT00031018
- Testing
- Aricept, IFN-alpha2A
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Frontotemporal Lobar Degeneration, Dementia
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in Frontotemporal Dementia
This study will use positron emission tomography (PET) imaging to measure a receptor in the brain that is involved in inflammation.
- Trial name
- NCT00613119
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Meningitis, Meningococcal, Meningococcal Sepsis
Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.
A fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. A fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease.
- Conditions
- Meningitis, Meningococcal, Meningococcal Sepsis, Meningococcal Disease, Meningococcal Infections
- Trial name
- PIC (NCT03378258)
- Where
- United Kingdom
- Volunteers
- 1,329 people
- Sponsor
- Belfast Health and Social Care Trust
Alzheimer Disease
Biomarkers for Monitoring Dementia Progression
The variable course of Alzheimer's disease (AD) and the paucity of adequate cures urges to implement new strategies for its early detection and clinical intervention.
- Trial name
- ADvance (NCT06855368)
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele Roma
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Alzheimer Disease
Exploratory Study of Low-Dose Whole-Brain Radiation Therapy With HeLaXON 1X in Patients With Mild Alzheimer's Disease Dementia
This randomized, sham-controlled, exploratory clinical trial will evaluate the efficacy and safety of HeLaXON, an investigational low-dose radiation therapy device, in patients with mild Alzheimer's disease dementia.
- Trial name
- LDRT-AD-03 (NCT07863011)
- Testing
- HeLaXON 1X Low-Dose Radiation Therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- ReadyCure Inc.