Clinical trials: Chronic Stress
Chronic Stress, Anxiety
Preventing Internalizing in Preadolescents Exposed to Chronic Stress
Racial and socioeconomic disparities in physical and mental health problems are large, persistent, and severe; begin during childhood; and stem from in part damage to physiologic stress response systems caused by chronic stress.
- Conditions
- Chronic Stress, Anxiety, Depression
- Trial name
- NCT02764138
- Testing
- Building a Strong Identity and Coping Skills
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Penn State University
Wellbeing, Mental Health
Many Trauma-affected Youth Face Long Waits for Therapy, Worsening Stress, and Avoidance. CISS, a 90-minute Session Based on Stanford's Cue-Centered Therapy, Offers Coping Tools and Psychoeducation During This Gap. This Pilot Tests CISS's Feasibility, Acceptability, and Impact on 30-40 Adolescents.
Many young people who have experienced traumatic events such as sexual assault, domestic violence, serious accidents, or natural disasters face long waits before they can begin full trauma-focused therapy.
- Conditions
- Wellbeing, Mental Health, Psychological, Stress
- Trial name
- CISS (NCT07558005)
- Testing
- Cue-Centered Therapy (CCT)-Informed Single Session Intervention (CISS)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Children With Chronic Illnesses, Caregiver Burden
Siblings as Caregivers
The current body of research fails to acknowledge or understand what type of care children are giving to their siblings, yet it appears to be a common practice in many cultures.
- Trial name
- NCT05937724
- Testing
- Family Caregiving
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Utah
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Stress, Generalized Anxiety
Enhancing Health in Rural Populations: Music as Therapy
The goal of this clinical trial is to learn whether a music-based intervention can improve mental and physical health and strengthen coping skills among adults living in residential care settings in northern Arizona.
- Conditions
- Stress, Generalized Anxiety, Chronic Pain, Depression Disorder
- Trial name
- NCT07538427
- Testing
- Music Based Intervention
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Prader-Willi Syndrome
Stress and Brain Response Using MEG in PWS
Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges.
- Trial name
- NCT04032639
- Where
- 2 sites in Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Autism Spectrum Disorder, Insomnia Chronic
Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism
Autism Spectrum Disorder (ASD) represents one of the most perplexing neurobiological disorders with a prevalence of 1 in 54 children.
- Conditions
- Autism Spectrum Disorder, Insomnia Chronic, Caregiver Burden
- Trial name
- NCT05373537
- Testing
- Cognitive behavioral therapy for Insomnia
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Stress Disorder
Mindfulness, Empathy and Social Integration. Its Relation With Chonic Stress
The objective of this project is to evaluate the effects of promoting the learning of empathy and pro-social behavior in health and interpersonal relationships in middle-aged children It has been shown that pro-social behavior…
- Trial name
- NCT04177017
- Testing
- Mindfulness-based intervention
- Where
- Argentina
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Diabetes Mellitus, Type 1, Epilepsy
Impact of Parental Perfectionistic Cognitions Self-compassion Intervention Effects on Shame in Child Health Context
Parents of children with long-term health conditions (LTCs) can experience shame related to parenting. Whilst self-compassion interventions (SCIs) can reduce parental shame, this has not been studied with parents of children with…
- Conditions
- Diabetes Mellitus, Type 1, Epilepsy, Asthma, Shame
- Trial name
- NCT03504605
- Testing
- Online self-compassion intervention
- Where
- United Kingdom
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Chronic Stress, Anxiety
Confirmatory Efficacy of the Building a Strong Identity and Coping Skills Program
The goal of this clinical trial is to the efficacy of the Building a Strong Identity and Coping Skills intervention within a sample of low-income and minoritized youth aged 11-14 who are seeking mental health treatment and have…
- Conditions
- Chronic Stress, Anxiety, Depression
- Trial name
- NCT05789446
- Testing
- Building a Strong Identity and Coping Skills
- Where
- 5 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Penn State University
Gulf War Syndrome, Chronic Fatigue Syndrome
Hyporeactivity and Gulf War Illness
This research project is a follow-up to the prior VA-funded study that found that chronic fatigue reported by many Gulf War veterans may be a symptom of dysfunctional cardiovascular stress response regulation.
- Conditions
- Gulf War Syndrome, Chronic Fatigue Syndrome, Post-Traumatic Stress Disorder
- Trial name
- NCT00100412
- Testing
- Graded dobutamine infusions, Graded phenylephrine injections, Psychosocial challenge involving socioevaluative public speaking
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Illness
Virtual ACT for Adolescent Stress
This study aims to test the effectiveness of a 6-week long virtual Acceptance Commitment group therapy as a non-pharmaceutical intervention to improving other functional outcomes for adolescents with a chronic medical condition…
- Trial name
- NCT04978610
- Testing
- Virtual Acceptance Commitment Therapy
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Obesity, Stress
Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain
About 15 to 20 percent of individuals living in the United States have chronic abdominal pain, often of unknown origin, which is often difficult to diagnose and treat.
- Conditions
- Obesity, Stress, Irritable Bowel Syndrome, Women
- Trial name
- NCT00824941
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Stress Disorders, Post-Traumatic
Evaluation of an Intensive Inpatient Psychotherapy Treatment for Severely and Early Traumatized Children (MOSES)
Evaluation of longitudinal treatment effects applying an intensive psychotherapeutic intervention for inpatients (age of participants: 6-13 years) with a multi-method-approach to address the complex nature of severe childhood…
- Trial name
- MOSES (NCT03894774)
- Testing
- Intensive in-patient psychotherapy treatment, Treatment as usual
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- LMU Klinikum
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial
The purpose of this study IS to explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions to…
- Trial name
- NorCAPITAL (NCT01040429)
- Testing
- Clonidine, Lactose capsula
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Stress, Psychological, Father-Child Relations
Hair Cortisol as Marker of Chronic Stress in Preterm and Term Fathers - Fathair-study
The goal of this observational study is to compare the paternal hair cortisol as a marker for chronic stress in prematurely born children to maturely born children.
- Conditions
- Stress, Psychological, Father-Child Relations, Premature Birth
- Trial name
- NCT05969431
- Testing
- measurement of cortisol level
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Excessive Crying, Prolonged Pain
Assessment of Prolonged Pain in Infants With Excessive Crying: Contribution of Infrared Thermal Imaging - The NEOTHERM Pilot Study
NEOTHERM is a multicenter, prospective, observational pilot study examining whether infrared thermal imaging (ITI) can contribute to the assessment of prolonged pain in infants with excessive crying.
- Trial name
- NEOTHERM (NCT07693179)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Chronic Disease, Mental Health
Alaska Alliance for Community Engagement Phase II: Partnership for Action Toward Health
The AK ACE-PATH Phase II study aims to pilot and implement a novel intervention, Tools for Arctic Health Promotion (TAHP), to address Alaska Native (AN) community priorities related to local health and community-level resilience.
- Conditions
- Chronic Disease, Mental Health, Caridovascular Disease, Stress
- Trial name
- AK ACE-PATH (NCT07801989)
- Testing
- Tools for Arctic Health Promotion
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Alaska Fairbanks