Clinical trials: Cleft Lip
Orofacial Clefts, Cleft Lip and Palate
Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft Surgery
This prospective, randomized study is designed to compare the efficacy and safety of three sedative-analgesic agents-intramuscular ketamine, intranasal nalbuphine, and intranasal dexmedetomidine-for procedural sedation in…
- Conditions
- Orofacial Clefts, Cleft Lip and Palate, Alveolar Ridge Defect
- Trial name
- KID-CLEFT (NCT07340008)
- Testing
- ketamine, Nalbuphine, Dexmedetomidine
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Esthetic Outcome of Injection of Botulinum Toxin Type-A in Cleft Lip Repair
Evaluation of the Effect of Botulinum Toxin Type-A Injection Prior to Surgical Correction of Complete Unilateral Cleft Lip Repair by Modified Millard Cheiloplasty
Evaluation of the effect of botulinum toxin type-A injection prior to surgical correction of complete unilateral cleftlip repair by modified millard cheiloplasty
- Trial name
- NCT03047499
- Testing
- Botulinum toxin type A
- Where
- Egypt
- Volunteers
- 2 people
- Sponsor
- Mostafa Khairy
Craniofacial Differences
Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences
This study will describe the use of an intervention, developed by an organization called Positive Exposure, to improve self-perceptions among adolescents and young adults who may encounter the stigma, or negative effect, of…
- Trial name
- NCT00340964
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Three Dimensional, Dento-Skeletal
Three Dimensional Evaluation of Dento-Skeletal Effects of Leaf Self Expander in Cleft Lip and Palate Patients
This study aims to evaluate the dento-alveolar changes after maxillary expansion in cleft lip and palate patients by Leaf Self Expander, as compared to conventional Rapid Maxillary Expander using digital cast analysis and…
- Conditions
- Three Dimensional, Dento-Skeletal, Leaf Self Expander, Cleft Lip
- Trial name
- NCT07384338
- Testing
- Rapid maxillary expansion, Leaf Self Expander
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Cleft Lip and Palate
Two Methods of Lip Taping as a Presurgical Orthopedic Appliance
A randomized clinical trial to compare the effectiveness of two methods of lip taping as a presurgical orthopedic appliances on maxillary arch dimensions in infants with bilateral cleft lip and palate.
- Trial name
- NCT05796336
- Testing
- Lip taping
- Where
- Iraq
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Unilateral Cleft Lip
Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair
The purpose of this study is to evaluate effect of platelet rich plasma on scar formation of unilateral cleft lip repair.
- Trial name
- NCT02958306
- Testing
- platelet rich plasma
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Cleft Lip
Orbicularis Oris Z-plasty Modification of Modified Millard Technique and the Esthetic Outcome of Cleft Lip Repair
This study aimed to evaluate the effect of orbicularis oris muscle z-plasty modification of modified Millard technique on the esthetic outcome and length of the repaired lip
- Trial name
- NCT04627389
- Testing
- orbicularis oris muscle Z- plasty modification of modified millard technique, modified millard technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fayoum University
Complete Unilateral Cleft Lip
Unilateral Cleft Lip Closure - Development of a New Hybrid Technique
Unilateral cleft lips can be treated with different incision techniques. According to a survey by the American Cleft Palate Association, the Millard II technique is currently used by the majority of US cleft surgeons.
- Trial name
- NCT05102513
- Testing
- Unilateral Cleft Lip Repair: Hybrid Technique, Unilateral Cleft Lip Repair: Millard 2 Technique
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Marco Kesting
Unilateral Cleft Lip, Nasoalveolar Molding
Nasolabial Soft Tissue Esthetics and Maxillary Changes in Unilateral Cleft Lip and Palate Using PreSurgical Infant Orthopedics With Different Approaches
The nasal deformity is an abnormality in the appearance and structure of the nose in cleft patients having unilateral cleft lip and palate (UCLP).
- Trial name
- PSIO (NCT05940389)
- Testing
- Naso Alveolar Mold, Taping with nasal elevator:
- Volunteers
- 24 people
- Sponsor
- Al-Azhar University
Cleft Lip, Cleft Palate
Oral Cleft Prevention Program
The purpose of this study is to asses if taking 4 mg of folic acid per day at preconception and during the first three months of pregnancy decreases the risk of having a child with cleft lip and palate compared to 0.4 mg folic…
- Trial name
- NCT00397917
- Testing
- Folic acid: 4 mg versus 0.4 mg per day
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Iowa
Cleft Lip and Palate
Otologic and Rhinologic Outcomes in Children With Clef Palate
OBJECTIVE: To compare otologic and rhinologic outcomes in patients with cleft palate according to surgical protocols and type of cleft. DESIGN: Monocentric retrospective and prospective analysis of medical reports.
- Trial name
- Clef Palate (NCT03708406)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Cleft Lip, Cleft Palate
Systematic Pediatric Care for Oral Clefts - South America
Cleft lip and palate are a significant component of morbid human birth defects in the developing world. This study measures the impact of having a child born with a cleft lip on subsequent maternal/infant family health, and…
- Conditions
- Cleft Lip, Cleft Palate, Congenital Defects
- Trial name
- NCT00097149
- Testing
- Systematic pediatric care
- Where
- Brazil
- Volunteers
- 696 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Congenital Disorder, Cleft Lip Palate
Clinical Application of Artificial Intelligence in New Borns With Cleft Lip and Palate
The goal of this observational study is to evaluate whether passive plate therapy using automated AI-designed devices can reduce cleft size in newborns with cleft lip and palate.
- Trial name
- CLIP-AI (NCT06970158)
- Testing
- AI-Designed Passive Plate Therapy
- Where
- 2 sites in India
- Volunteers
- 70 people
- Sponsor
- University Hospital, Basel, Switzerland
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Unilateral Cleft Lip
Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy.
the aim of the study will be directed to evaluate clinically the effect of botulinum toxin type A injection on reducing the scar following cleft lip surgical repair.
- Trial name
- NCT07137234
- Testing
- Modified Millard rotation advancement flap technique, botulinum toxin injection (BTX A) before surgical intervention
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Mansoura University
Cleft Lip and Palate
Skeletal and Dental Maturational Stages in a Sample of Egyptian Subjects With Cleft Lip and Palate Deformity
The aim of this research is to evaluate the skeletal and dental maturation of cleft lip and palate patients in a sample of Egyptian population using the CVM as indicator for the skeletal maturation and the Demirjian method as…
- Trial name
- NCT05031039
- Volunteers
- 250 people
- Sponsor
- Cairo University
Cleft Lip and Palate
Transverse Dento-skeletal Effects of Two Rapid Palatal Expansion Appliances in Cleft Lip and Palate Patients
Aim of the study: to compare the effect of Hyrax appliance and the Haas appliance improving the transverse skeletal and dental dimensions in cleft lip and palate patients during mixed dentition.
- Trial name
- NCT04236466
- Testing
- hyrax appliance, haas appliance
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cleft Lip and Palate
Alt-RAMEC Expansion and Protraction by EDO in Cleft Lip and Palate Patient
Evaluate the treatment outcome of Alternate Rapid Maxillary Expansion and Constriction Alt-RAMEC protocol on patients with cleft lip and palate, using a differential opening expander and face mask which will be measured and…
- Trial name
- NCT04970095
- Testing
- Maxillary Expander with Differential Opening (EDO), Petit Face Mask
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Cleft Lip and Palate
Assessment of Maxillary Arch Depth and Width in a Group of Surgically Repaired Unilateral Cleft Lip and Palate Children Versus Normal Children .
The aim of the present study is to determine the effect of surgically repaired UCLP on dental arch dimensions and the need for orthodontic intervention in comparison with other healthy children , the presence of dental anomalies…
- Trial name
- NCT04791813
- Testing
- Alginate impressions , Photographic data and panoramic radiographs .
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Relationship Between the Exposure of Glucocorticoids During Pregnancy and Orofacial Cleft Development
A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis
Glucocorticoids are drugs that have many effects on body metabolism, raise sugar level in the blood, and reduce inflammation. By applying a statistical technique for combining the findings from a systematic literature review…
- Trial name
- NCT03788863
- Testing
- Diflucortolone valerate (BAY866146)
- Where
- Germany
- Volunteers
- 99,999 people, healthy volunteers welcome
- Sponsor
- LEO Pharma