Clinical trials: Clinical High Risk
STEMI
Follow up of Clinical Outcome of Deferred vs Immediate Stenting in High Thrombus Stemi Patients
To compare the effect of immediate stenting versus deferred stenting - with use of glycoproteinIIbIIIa inhibitor \& low molecular weight heparin - on the clinical outcome -3 and 6 months after stenting \& also infarct size using…
- Trial name
- NCT05793671
- Testing
- PPCI in heavy thrombus burden STEMI patients
- Volunteers
- 440 people
- Sponsor
- Assiut University
B-ALL
Blinatumomab as Maintenance Therapy in Patients With High-risk B-lineage Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation
Patients ≥ 14 years of age after B-ALL allogeneic transplantation received 4 cycles of maintenance therapy with blinatumomab +/- TKI and were followed for more than 1 year to assess overall survival (OS), relapse-free survival…
- Trial name
- NCT06658938
- Testing
- Blinatumomab
- Volunteers
- 30 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Central Nervous System Neoplasms, Pediatric Cancer
Pediatric Prospective Personalized Immune and Target Identification Trial
PPROSPERITIT is a prospective clinical study assessing the use of comprehensive molecular profiling to define the best matching targeted and immune treatment for relapsed, refractory or very high risk pediatric CNS tumors.
- Conditions
- Central Nervous System Neoplasms, Pediatric Cancer, GEN1 Gene Mutation, Tumor, Brain
- Trial name
- PPROSPERITIT (NCT04859543)
- Testing
- FoundationOneHeme
- Where
- 3 sites in Austria, Czechia
- Volunteers
- 80 people
- Sponsor
- Masaryk University
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG
This is a phase I, open label, plus expansion clinical trial evaluating the safety and tolerability of rHSC-DIPGVax in combination with BALSTILIMAB and ZALIFRELIMAB.
- Trial name
- NCT04943848
- Testing
- rHSC-DIPGVax, Balstilimab, Zalifrelimab
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
High-risk Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia (CMML)
A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias
Study CBX-250-001 is a Phase 1, open-label, dose-escalation study of CBX-250 in participants with relapsed/refractory AML, HR-MDS, CMML, and CML. Participants aged ≥ 12 years are planned to be enrolled.
- Conditions
- High-risk Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia (CMML), AML - Acute Myeloid Leukemia, Chronic Myeloid Leukemia
- Trial name
- CROSSCHECK-001 (NCT06994676)
- Testing
- CBX-250
- Where
- 11 sites in United States
- Volunteers
- 72 people
- Sponsor
- Crossbow Therapeutics, Inc.
Respiratory Syncytial Virus (RSV)
Observational Program to Assess Respiratory Syncytial Virus (RSV) Hospitalization Rate in Population of Children at High-risk of Serious RSV Illness Who Received Palivizumab Immunoprophylaxis
This was a non-interventional, prospective, multi-center study with no control group designed to assess the effectiveness of palivizumab in a population of infants at high-risk of serious Respiratory Syncytial Virus (RSV) illness…
- Trial name
- SUNRISE (NCT02282982)
- Volunteers
- 359 people
- Sponsor
- AbbVie
Executive Dysfunction, ASD
Effect of rTMS on the Abnormal Executive Function of ASD Children
In this study, the investigators will explore the effects of repetitive transcranial magnetic stimulation (rTMS) on executive function deficits in high function autism spectrum disorder.
- Trial name
- NCT04237870
- Testing
- Active cTBS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Triple Negative Breast Cancer
A Trial Using ctDNA Blood Tests to Detect Cancer Cells After Standard Treatment to Trigger Additional Treatment in Early Stage Triple Negative Breast Cancer Patients
c-TRAK TN is a multi-centre phase II study, consisting of a circulating tumour DNA (ctDNA) surveillance component and a therapeutic component.
- Trial name
- c-TRAK-TN (NCT03145961)
- Testing
- Pembrolizumab
- Where
- 17 sites in United Kingdom
- Volunteers
- 208 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Clinical High Risk for Psychosis
Evaluation of the Treatment Approach ROBIN
The prevention of schizophrenia and other psychotic disorders has led researchers to focus on early identification of individuals at Clinical High Risk (CHR) for psychosis and to treat the at-risk symptoms in the pre-psychotic…
- Trial name
- Robin (NCT03829527)
- Testing
- Psychotherapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Status Asthmaticus
Treating Exacerbations of Asthma With Oral Montelukast in Children
This research will establish a mg/kg dose for a future RCT to determine the efficacy of high-dose oral montelukast for children with moderate and severe acute asthma exacerbations.
- Trial name
- TEAM (NCT05819541)
- Testing
- Montelukast Oral Granules, Albuterol, Corticosteroid
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Tuberous Sclerosis Complex
Dermatologic Patterns of Tuberous Sclerosis Patients and Somatic Mutation Relationship
Tuberous Sclerosis is a rare genetic disorder that affects about one in 15,000 individuals. It is part of the phacomatoses: a germline mutation of the gene Tuberous Sclerosis Complex 1 (TSC1) or TSC2 causes a protein dysfunction…
- Trial name
- NCT04112537
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Ulcer
Healing Efficacy of Isobutyl Cyanoacrylate High Viscous Solution in Treatment of Traumatic Ulcer in Children
30 children with traumatic oral ulcer that will be divided into equal three groups. Group A (Isobutyl cyanoacrylate) includes children will be treated with isobutyl cyanoacrylate high viscous solution only once during the…
- Trial name
- NCT06742983
- Testing
- Isobutyl cyanoacrylate, Chlorhexidine (0.2%), Normal Saline (0.9% NaCl)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia
Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer
Background: Individuals may be prone to develop blood or lymph node cancers (leukemia or lymphoma) for a variety of reasons, including genetic predisposition to these cancers, environmental exposures or other medical conditions.
- Conditions
- Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Hodgkin Disease, NonHodgkin Lymphoma
- Trial name
- NCT00039676
- Where
- 2 sites in United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
COVID-19; and High Infection Risk of SARS-CoV-2
Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects
This is a randomized, double-blind, placebo-controlled, phase I clinical study to evaluate the tolerability, safety, pharmacokinetic profile and immunogenicity of JS016 (anti-SARS-CoV-2 monoclonal antibody) injection in Chinese…
- Trial name
- NCT04441918
- Testing
- JS016 (anti-SARS-CoV-2 monoclonal antibody)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
High-dose Biapenem
Clinical Efficacy of Combination Therapy Based on High-dose Biapenem in CRKP Infections
Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect.
- Trial name
- NCT04552444
- Testing
- Biapenem
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pediatric Sedation
Evaluation of the Efficacy of Oxygen Therapy and Clinical Feasibility of High Flow Nasal Cannula During Moderate and Deep Sedation in Pediatric Patients
The investigators evaluate the efficacy and safety of routine administration of oxygen during moderate or deep sedation in pediatric patients.
- Trial name
- NCT04852432
- Testing
- high flow nasal cannula, nasal prong
- Where
- South Korea
- Volunteers
- 258 people
- Sponsor
- Seoul National University Hospital
Dental Caries in Children
Cost-effectiveness of Topical Fluoride in Preventing Deciduous Dental Caries in Preschool Children
Fluoride foam and fluoride varnish are effectiveness in prevention deciduous dental caries. However, the relative clinical efficacy and cost-effectiveness of these two interventions are uncertain.
- Trial name
- NCT05025163
- Testing
- 1.23% fluoride foam application, 2.26% fluoride varnish application
- Volunteers
- 1,083 people
- Sponsor
- National Center for Chronic and Noncommunicable Disease Control and Prevention, China CDC
Clinical High Risk for Psychosis (CHR)
French Validation of Schizophrenia Proneness Instrument- Child Youth
The clinical concept of a at risk mental state of developing psychosis is based on the identification of attenuated psychotic symptoms during the prodromal phase of psychoses (Schmidt et al., 2015).
- Trial name
- SPI-CY-Fr (NCT06649552)
- Testing
- Psychiatric and psychological diagnostic tests
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Psychothérapique de Nancy
Obesity, Insulin-resistant
HIT in Insulin-resistant and Insulin-sensitive Obese Adolescents
Evaluate the effects of HIT on the cardiorespiratory performance and substrate oxidation of insulin-resistant and insulin-sensitive obese adolescents.
- Conditions
- Obesity, Insulin-resistant, Adolescents
- Trial name
- NCT03042234
- Testing
- Group Insulin-Resistant, Group Insulin-Sensitive
- Where
- 3 sites in Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Malaria, Chemoprophylaxis
Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprophylaxis in Tanzania
Background: Malaria prevalence has declined globally following the scale-up of the interventions, including insecticide-treated bed-net, indoor residual spraying, and prompt diagnosis and treatment with artemisinin-based…
- Conditions
- Malaria, Chemoprophylaxis, Underfive Children
- Trial name
- SMC-DP (NCT05874869)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- Tanzania
- Volunteers
- 13,800 people
- Sponsor
- Richard Mwaiswelo