Clinical trials: Clinical Pain
Congenital Heart Defect, Chronic Pain
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care
Over the past four decades, it has become clear that childhood physical activity carries with it a myriad of beneficial effects.
- Conditions
- Congenital Heart Defect, Chronic Pain, Concussion Post Syndrome, Cerebral Palsy
- Trial name
- NCT04106154
- Testing
- Kinesiology Support
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Children's Hospital of Eastern Ontario
Postoperative Pain, Flare up
Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence
This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical…
- Conditions
- Postoperative Pain, Flare up, Flare Up, Symptom
- Trial name
- NCT07084194
- Testing
- Chitosan Nanoparticles Irrigant, aloe vera nanoparticles irrigant, Diode Laser Activation
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Minia University
Pain Management, Anxiety
Distraction With Virtual Reality From Pain and Anxiety for Patients With Hematological Malignancies
The goal of this clinical trial] is to study the effectiveness of Virtual Reality (VR) in reducing pain and anxiety during painful procedures for patients with hematological malignancies The main question[s] it aims to answer…
- Conditions
- Pain Management, Anxiety, Procedures, Hematological Neoplasms
- Trial name
- NCT07085065
- Testing
- VR session
- Where
- Tunisia
- Volunteers
- 365 people
- Sponsor
- Yesmine Amara
Dental Anxiety, Pain
Dental Anxiety and Pain During Inferior Alveolar Nerve Block in Children: the Effects of Two Distraction Techniques
Objectives: To compare the effectiveness of virtual reality (VR) and external cooling and vibration distraction techniques on dental anxiety and pain in children during inferior alveolar nerve block (IANB).
- Conditions
- Dental Anxiety, Pain, Distraction Methods, Local Anesthesia
- Trial name
- NCT06788301
- Testing
- Inferior Alveolar Nerve Block, VR eyeglasses, Buzzy device
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Pneumoperitoneum, Pain
Effect of Low-pressure Pneumoperitoneum on Pain and Inflammation Post Laparoscopic Cholecystectomy
The purpose of this study is to assess the effect of low-pressure pneumoperitoneum on post operative pain and inflammation in patients undergoing elective laparoscopic cholecystectomy by comparing it to standard practice.
- Conditions
- Pneumoperitoneum, Pain, Inflammation
- Trial name
- NCT04779515
- Testing
- low-pressure pneumoperitoneum, standard-pressure pneumoperitoneum
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- University of Jordan
Patellofemoral Pain Syndrome
A Confirmatory Trial of Multidisciplinary Digital Therapeutics for Patellofemoral Pain Syndrome
This randomized controlled confirmatory study will be evaluating an mobile application, MORA Cure (ETH-01K), owned by EverEx, Inc., to examine safety and effectiveness in individuals with patellofemoral pain syndrome.
- Trial name
- NCT06260865
- Testing
- MORA Cure, Treatment as Usual
- Where
- 10 sites in South Korea
- Volunteers
- 216 people
- Sponsor
- EverEx Inc.
Labor Pain, Labor Anxiety
Effectiveness of Sacral Massage on Labor Pain, Depression, Stress, and Anxiety
to identify the effectiveness of sacral massage on labor pain, depression, stress, and anxiety: A randomized clinical trial
- Conditions
- Labor Pain, Labor Anxiety, Labor Stress, Labor Depression
- Trial name
- ESMLPDAS (NCT07501598)
- Testing
- Sacral Massage
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- University of Basrah
Chronic Pain
Clinical Assessment of Pain Processes in Pediatric Patients With Chronic Musculoskeletal Pain
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain during childhood does not only impact physical and psychological aspects of daily life but may…
- Trial name
- MSK (NCT04308044)
- Where
- Canada
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Nasal Deformity, Revision Rhinoplasty
Effect of Costal Harvesting Technique on Postoperative Donor-site Morbidity: Does Muscle Sparing Technique Cause Less Postoperative Pain ? A Clinical Trial
The purpose of this study was to investigate the effect of 'muscle sparing technique' while harvesting costal/rib cartilage on postoperative donor-site morbidity -namely postoperative pain.
- Conditions
- Nasal Deformity, Revision Rhinoplasty, Autogenous Rib Graft, Costal Cartilage
- Trial name
- COSTA (NCT02818634)
- Testing
- Harvesting rib cartilage
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Postoperative Pain
Evaluation of Postoperative Pain in Children
Postoperative pain is a common symptom of a flare up after root canal treatments (RCTs). Insufficient instrumentation, extrusion of irrigation solutions and debris and existence of a periapical lesion are the factors affecting…
- Trial name
- NCT04510571
- Testing
- Evaluating Postoperative Pain After Root Canal Treatment with Protaper Next, Evaluating Postoperative Pain After Root Canal Treatment with Reciproc Blue Files
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ege University
Dental Anxiety
Comparison of Virtual Reality and Mixed Reality Head-Mounted Displays for Dental Anxiety Control During Local Anesthesia in Children
Dental anxiety is a common problem in children and may negatively affect cooperation, pain perception, and treatment success during dental procedures.
- Trial name
- NCT07398105
- Testing
- Audiovisual Distraction Using Head-Mounted Display
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Pain
Does the Order in Which Vaccines Are Administered Affect Pain Response?
The objective of this study is to determine whether there should be a predetermined sequence recommended for administering these two vaccines, with the less painful vaccine being given first.
- Trial name
- NCT00390130
- Testing
- Pentacel (DPTaP+Hib), Prevnar (conjugated pneumococcal vaccine)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Limb Injury
Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine
The purpose of this study is to determine if IN fentanyl (1.5 µg/kg) or IN ketamine (1 mg/kg) is more effective at 30 minutes than oral morphine (0.5 mg/kg) in reduction of moderate and severe pain associated with limb injuries…
- Trial name
- ANTAMIN (NCT06464146)
- Testing
- Morphine, IN fentanyl, IN ketamine
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Arteriosclerosis, Angina Unstable
Stents, Drug Eluting Stents, and CABG- Financial and Clinical Impact.
Options for coronary revascularization include stent implantation and coronary bypass surgery. Both modalities have their unique advantages and disadvantages in terms of clinical outcomes as well as financial impact on the…
- Conditions
- Coronary Arteriosclerosis, Angina Unstable, Myocardial Infarction
- Trial name
- NCT00394680
- Volunteers
- 700 people
- Sponsor
- Shaare Zedek Medical Center
Angle Class I Malocclusion, Dental Crowding
Clinical Performance of Direct-Printed Versus Thermoformed Aligners
The goal of this study is to evaluate and compare the clinical effectiveness of in-office directly 3D-printed clear aligners versus conventional multilayered thermoformed aligners.
- Conditions
- Angle Class I Malocclusion, Dental Crowding, Tooth Spacing
- Trial name
- NCT07637227
- Testing
- Direct-Printed Aligner, Thermoformed aligner
- Where
- 3 sites in Iraq
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Inflammation, Cancer
NSAID Effects on Clinical and Imaging Breast Biomarkers
This study has two purposes. One is to determine if daily sulindac decreases breast density; a risk factor for breast cancer development.
- Conditions
- Inflammation, Cancer, Pain, Hypertension
- Trial name
- NCT01761877
- Testing
- Sulindac
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Stony Brook University
Hemophilia A
Effects of Ultrasound and Infrared on Joint Pain and Movement in Hemophilia A Patients.
The study aims to compare the effectiveness of therapeutic ultrasound and infrared in managing hemarthrosis in patients with Hemophilia A, focusing on specific outcomes like joint pain, swelling, muscle atrophy, and range of…
- Trial name
- Hemophilia A (NCT07116993)
- Testing
- theraputic ultrasound, infrared radiation
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Danyal Ahmad
Breast Disease, Breast Neoplasms
Pattern of Clinical Presentation of Different Breast Disease in Surgical Opd at BPKIHS
Research Title PATTERN OF CLINICAL PRESENTATION OF DIFFERENT BREAST DISEASE IN SURGICAL OPD AT BPKIHS Rationale: The Study will help us to know about pattern of presentation of different breast diseases Aims and Objectives: 1.
- Conditions
- Breast Disease, Breast Neoplasms, Breast Pain, Breast Fibroadenoma
- Trial name
- NCT06026176
- Where
- Nepal
- Volunteers
- 1,023 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
Irreversible Pulpitis
Effect of Addition of Mannitol to Bupivacaine on IANB Success and Post-endodontic Pain
Inferior alveolar nerve block using either 0.5% bupivacaine alone or in addittion to mannitol in patients with irreversible pulpitis in mandibular molars.
- Trial name
- NCT03749408
- Testing
- bupivacaine plus mannitol, bupivacaine alone
- Volunteers
- 60 people
- Sponsor
- Cairo University