Clinical trials: Clinical Pain
Dysmenorrhea
Efficacy and Safety Study of Low Dose Oral Contraceptive Pill to Treat Dysmenorrhea
The purpose of this study is to determine whether combination oral contraceptive pill of Norethindrone \& Ethinyl estradiol is effective in the treatment of dysmenorrhea associated with endometriosis.
- Trial name
- NCT00212342
- Testing
- Norethisterone,Ethinylestradiol, Sugar pill
- Volunteers
- 100 people
- Sponsor
- Nobelpharma
Congenital Heart Defect, Chronic Pain
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care
Over the past four decades, it has become clear that childhood physical activity carries with it a myriad of beneficial effects.
- Conditions
- Congenital Heart Defect, Chronic Pain, Concussion Post Syndrome, Cerebral Palsy
- Trial name
- NCT04106154
- Testing
- Kinesiology Support
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Children's Hospital of Eastern Ontario
Retreatment, Cryotherapy
Effect of Intracanal Cryotherapy on Postoperative Pain
Introduction: Since 1960, cryotherapy, involving the application of cold, has been used in various fields of medicine for pain treatment.
- Trial name
- NCT06764823
- Testing
- Cryotherapy, Control
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN)
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants…
- Conditions
- Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy
- Trial name
- NCT06614322
- Testing
- Pregabalin, Duloxetine
- Where
- 7 sites in United States
- Volunteers
- 190 people
- Sponsor
- University of Rochester
Neuropathy, Paraneoplastic
MC-5A for Chemotherapy Induced Peripheral Neuropathy
Painful chemotherapy induced peripheral neuropathy (CIPN) is a common complication of cancer therapy with few treatment options.
- Trial name
- NCT01261780
- Testing
- MC-5A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Healthy Volunteers
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants
This is a first-in-human study of NH302 injection in healthy participants. The study will test single intravenous doses of NH302 to evaluate its safety and tolerability, how the body processes NH302, and its effects on selected…
- Trial name
- NCT07892469
- Testing
- NH302 injection
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Cancer, Pain
An Efficacy and Safety Study of Hydromorphone Hydrochloride (HCl) Oral Osmotic System (OROS) in the Reduction of Breakthrough Pain Medication Frequency in Participants With Cancer
The purpose of this study is to evaluate the clinical efficacy of hydromorphone hydrochloride (HCl) Oral Osmotic System (OROS) by assessing the extent of reduction of medication frequency for the management of breakthrough pain…
- Trial name
- NCT01006356
- Testing
- Hydromorphone HCl OROS
- Volunteers
- 141 people
- Sponsor
- Janssen Korea, Ltd., Korea
Postoperative Pain, Flare up
Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence
This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical…
- Conditions
- Postoperative Pain, Flare up, Flare Up, Symptom
- Trial name
- NCT07084194
- Testing
- Chitosan Nanoparticles Irrigant, aloe vera nanoparticles irrigant, Diode Laser Activation
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Minia University
Axial Spondyloarthritis
Treatment of Axial Spondyloarthritis With Reduced Doses of NSAIDs
The following study investigates the role of information/expectancies in the response to Ibumetin and placebo. The study is a double-blind randomized controlled trial with crossover, within subjects repeated measurements.
- Trial name
- NCT02089529
- Testing
- Ibuprofen
- Where
- Norway
- Volunteers
- 8 people
- Sponsor
- University Hospital of North Norway
Heal Wound, VAS Will be Used to Assess Pain Postoperative
Evaluation of the Effect of Different Biomaterials on Palatal Wound Healing.
All study subjects will sign written informal consent form before enrolment. They will be divided into four groups, 10 patients each: Group I: Palatal wound will be left to heal spontaneously, Group II: Palatal wound will be…
- Trial name
- NCT07072182
- Testing
- Palatal wound will be covered with Ora-aid patch, Palatal wound will be covered with Composite stent, Palatal wound will be covered with PRF
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Fatma saad saad mahmoud elsherbini
Temporomandibular Disorder (TMD)
Effect of Active Mandibular Techniques and Specific Cranio-cervical Therapeutic Exercise in Patients With Temporomandibular Disorders and Bruxism (AMaCe-TB)
Temporomandibular Disorders (TMD) are a common source of pain and functional limitation affecting the stomatognathic system. They frequently lead to difficulties in mastication, decreased quality of sleep, limited mandibular…
- Trial name
- NCT07303361
- Testing
- Mandibular Muscle Energy Technique, Modified suboccipital inhibition technique
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Thoracotomy
Thoracotomy: Intercostal Nerve Block Versus Epidural Anesthesia
Postoperative pain and consecutive reduction of pulmonary function after thoracic surgery still is a major clinical problem and challenge in anesthesia.
- Trial name
- NCT01076894
- Testing
- epidural anesthesia, intercostal anesthesia
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- University of Ulm
Fibromyalgia, Pregabalin
The Efficacy and Safety of Pregabalin Combined With Venlafaxine in Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread pain, fatigue, and emotional disorders. Its onset is related to factors such as central sensitization and imbalance of neurotransmitters.
- Conditions
- Fibromyalgia, Pregabalin, Venlafaxine, Pain
- Trial name
- NCT07186751
- Testing
- Pregabalin, Pregabalin with venlafaxine
- Where
- 2 sites in China
- Volunteers
- 750 people
- Sponsor
- Beijing Tiantan Hospital
Menopausal Symptoms
A Clinical Trial on the Efficacy of a Combination Herbal Product, Biotropics' Nu Femme, on Menopausal Symptoms and Quality of Life in Women
The purpose of this study is to assess the effectiveness of an herbal combination product called Nu Femme, on menopausal symptoms in peri-menopausal women.
- Trial name
- 14NMHB (NCT02269891)
- Testing
- Nu Femme
- Where
- 4 sites in Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Facet Joint Pain; Low Back Pain
Sidekick vs Conventional Cannula in Lumbar Medial Branch Radiofrequency Ablation
Lumbar facet joint-mediated chronic low back pain is a common cause of disability. Radiofrequency ablation (RFA) of the lumbar medial branches is an established interventional pain treatment.
- Trial name
- SIDE-RFA (NCT07475689)
- Testing
- Lumbar Medial Branch Radiofrequency Ablation, Triamcinolone (20 g), bupivacain 0.5% 2ml
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Unstable Angina
Research on the Clinical Effect of Effective Prescription in Treating Unstable Angina.
This study evaluates the clinical efficacy of the famous prescription in the treatment of unstable angina pectoris. All of the patients will be divided into 4 arms according to their syndrome type.
- Trial name
- NCT03171597
- Testing
- Anti-Platelet Drugs, Lipid Regulating Drugs, Coronary Vasodilator
- Volunteers
- 240 people
- Sponsor
- Jun Li
Lumbar Muscle Strain
Clinical Study on Intensive Multi-acupuncture in the Treatment of Lumbar Muscle Strain.
Acupuncture is widely used as a routine treatment for lumbar muscle strain. The aim of this randomized controlled trial is to evaluate the effectiveness of the intensive multi-acupuncture method.
- Trial name
- NCT06286969
- Testing
- acupuncture
- Volunteers
- 108 people
- Sponsor
- Xu Xinnan
Spinal Metastasis
Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases
This study will compare pain (primary end-point) and local metastatic tumor control (secondary end-point) after dose-intensified image-guided fractionated stereotactic body radiation therapy (SBRT) for painful mass-type spinal…
- Trial name
- DOSIS RCT (NCT02800551)
- Testing
- dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT)
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- University of Zurich
Necrotic Pulp
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
The aim of this study is to compare the degree of postoperative pain and the antimicrobial effect in terms of bacterial count reduction after using co-amoxiclav-clindamycin solution versus MTAD and sodium hypochlorite irrigating…
- Trial name
- NCT04035070
- Testing
- co-amoxiclav-clindamycin solution, MTAD, 2.5% sodium hypochlorite
- Where
- Egypt
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Cairo University
Transpalatal Arch (TPA), Oral Health Related Quality of Life (OHRQoL)
Comparing Clinical Application of Innovatedly Made Transpalatal Arch (TPA) From 3D Reconstructed Model and Conventionally Made TPA
Trans-palatal Arch or TPA is an intra oral device that is occasionally used in conjunction of orthodontic fixed appliance treatment. It has two main types, the fixed or removable TPA.
- Conditions
- Transpalatal Arch (TPA), Oral Health Related Quality of Life (OHRQoL), Oral Health Impact Profile Short Version 14 (OHIP 14), Orthodontic Pain
- Trial name
- NCT03755622
- Testing
- Conventional Transpalatal Arch (TPA), Transpalatal Arch (TPA) fabricated from 3D reconstructed model
- Where
- Malaysia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Malaya
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