Clinical trials: Closed Loop
Type 1 Diabetes Mellitus
FASter Insulin in Closed-loop Technology in Children
The main objective of this study is to determine whether 24/7 hybrid closed-loop insulin delivery under free living conditions applying faster insulin aspart (FiAsp) is superior to 24/7 hybrid closed-loop insulin delivery…
- Trial name
- FAST-Kids (NCT04759144)
- Testing
- CamAPS FX using faster insulin aspart, CamAPS FX using standard insulin aspart
- Where
- 2 sites in United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Fully Closed Loop At Home (FCL@Home)
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a…
- Trial name
- NCT06041971
- Testing
- AIDANET system
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes
Impact of Hybrid Closed-Loop Systems on Sleep and Psychosocial Outcomes in Youth With T1D and Their Parents
This study evaluates the impact of the hybrid closed-loop insulin delivery systems on sleep in youth with type 1 diabetes and their parents.
- Trial name
- NCT04431947
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Colorado, Denver
Type1 Diabetes
Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes
Randomized trial of youth aged 7-<18 years with newly diagnosed stage 3 type 1 diabetes (T1D) to assess the effect of both (1) near-normalization of glucose concentrations achieved through use of a hybrid closed loop (HCL) system…
- Trial name
- CLVer (NCT04233034)
- Testing
- HCL, verapamil 120mg tablet, non-HCL
- Where
- 6 sites in United States
- Volunteers
- 113 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes
Objective: To assess the efficacy and safety of an insulin-glucagon dual-hormone (DH) closed-loop system compared with an insulin-only single-hormone (SH) closed-loop system in adolescent with type 1 diabetes.
- Trial name
- DHCL2021 (NCT04949867)
- Testing
- Glucagon, Closed-loop System
- Where
- 2 sites in Denmark
- Volunteers
- 11 people
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 1
Comparison With Observational Methods and Performance Assessment From Real-life Experience of Closed-Loop Insulin Delivery Systems
This study aims to compare glycemic control obtained under closed loop depending on the system : Smartguard (Medtronic 780) versus Control IQ (Tandem) in patients with diabetes type 1.
- Trial name
- COMPARE-CLIDS (NCT05932966)
- Testing
- Insulin closed-loop delivery system
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Centre Hospitalier Sud Francilien
Infant,Premature
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
Extremely low gestational age neonates (ELGANs), i.e. those born at <28 weeks, frequently experience intermittent hypoxemic/hyperoxemic episodes.
- Trial name
- FiO2-C (NCT03168516)
- Testing
- closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C)
- Where
- 32 sites in China, Germany and 2 more
- Volunteers
- 1,065 people
- Sponsor
- University Hospital Tuebingen
Persistent Pulmonary Hypertension of the Newborn, Inhaled Nitric Oxide
Close Loop Smart Weaning for INO With PPHN
In contemporary clinical practice concerning the administration of inhaled nitric oxide (iNO) within neonatal intensive care units (NICUs), a stepwise reduction approach is frequently employed in accordance with established…
- Trial name
- NCT06832163
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 1
Evaluating the Efficacy and Quality of Life Impact of Transitioning to Advanced Hybrid Closed-Loop Insulin Pump Therapy in Romanian Children With Type 1 Diabetes Mellitus
The proposed study aims to demonstrate the potential benefits of transitioning T1DM children from predictive low glucose suspend insulin pump therapy to advanced hybrid closed-loop insulin pump therapy in Romania.
- Trial name
- NCT06326489
- Testing
- Switching to the Medtronic 780G insulin pump
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- ELIAS Emergency University Hospital
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop for Teens
An open-label, three-centers, controlled, randomized, and crossover study containing 14 days of baseline period with standard of care (SOC) therapy followed by two-sessions of 4-weeks home study phase with Diabeloop closed-loop…
- Conditions
- Closed Loop, Diabetes Mellitus, Type 1, Adolescents (12 to 17 Years Old)
- Trial name
- DBL4T (NCT04725591)
- Testing
- Dexcom G6 Continuous Glucose Monitoring, MEDISAFE WITH External Insulin Pump, Diabeloop Software (Model predictive control)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 49 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Chronic Pain
Long-term Effectiveness, Safety, and Performance of the Evoke Closed-Loop SCS System to Treat Patients With Chronic Pain of the Trunk and/or Limbs
The objective of this multicountry, multicentre, prospective study is to evaluate the long-term clinical effectiveness, safety, and performance of the Evoke System in the treatment of chronic pain of the trunk and/or limbs in a…
- Trial name
- Domburg (NCT04627974)
- Testing
- Evoke Spinal Cord Stimulation (SCS) System
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people
- Sponsor
- Saluda Medical Pty Ltd
Type 1 Diabetes, Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
A closed-loop insulin system, often labelled the "artificial pancreas" (AP), consists of an insulin pump, a continuous glucose monitor, and an interface coordinating between them to regulate insulin dosage based on glucose…
- Trial name
- SEMA SMA (NCT06387199)
- Testing
- Semaglutide with 4 meal strategies
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Minimally Conscious State
Closed-loop tDCS in Patients in Minimally Conscious State
This research will test a closed-loop system using EEG-arousal measures (spectral entropy) to define the best moment of the day for application of transcranial direct current stimulation (tDCS) in patients in MCS This study aims…
- Trial name
- NCT03810079
- Testing
- Anodal transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University of Liege
Type 1 Diabetic Nephropathy
The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most frequent microvascular complications of diabetes mellitus, affecting 25 to 40% of patients with type 1 diabetes (T1DM).
- Trial name
- NCT06115460
- Testing
- oral sitagliptin supplementation
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Type 1 Diabetes Mellitus
Supporting Parents of Young Children With Type 1 Diabetes in Closed-Loop System
This study will examine the impact of a closed-loop insulin delivery system intervention on health and psychological outcomes in families with young children with Type 1 Diabetes (T1D).
- Trial name
- NCT03354286
- Testing
- Developmental & Technological Demands, Distress Reduction, Nutrition, Set Point, & C:I Ratio
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Type 1 Diabetes
Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System
The purpose of this study is to test an insulin management system ("Control-to-Range (CTR) system") in an inpatient setting to see if the system is safe and effective enough to test in a future at-home study.
- Trial name
- CTR (NCT01271023)
- Testing
- Control-to-Range Automated Insulin Management System
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 57 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Closed-Loop Control in Young Children 5-8 Years Old Using DiAs Platform
The overall aim of this proposed research is to determine the safety, feasibility and efficacy (AP vs at home use of SAP) of the Diabetes Assistant (DiAs) controller in day and night closed-loop control in young children 5-8…
- Trial name
- NCT02750267
- Testing
- Diabetes Assistant (DiAs) with Closed-Loop
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes, Insulin Therapy
Study on the Use of the Insulin Pump Tandem X:2 With Control IQ Algorithm - Update
The aim of this observational clinical trial is to obtain data on the safety, efficacy and satisfaction of the Tandem T:Slim X:2 Pump System in patients with type 1 diabetes.
- Trial name
- UNIQUE (NCT05118945)
- Testing
- Insulin pump Tandem: t:slim X2
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Type 1 Diabetes Mellitus
Pramlintide and Fiasp Closed-Loop With a Simple Meal Announcement
The aim of this pilot study is to generate preliminary data of (i) Fiasp-plus-Pramlintide closed-loop system with a simple meal announcement, compared to (ii) Fiasp-alone closed-loop system with full carbohydrate counting, in…
- Trial name
- NCT03993366
- Testing
- Fiasp+Pramlintide Closed-Loop System, Fiasp Closed-Loop System
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University
Diabetes, Type I
Closing the Loop Between Glucose Sensor and Insulin Pump-developing an Algorithm
An open interventional data collection study in order to build a database to close the loop between glucose sensor and insulin pump.
- Trial name
- NCT00541515
- Testing
- continuous glucose sensors and insulin pump
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Rabin Medical Center