Clinical trials: Closed-Loop
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes
High variability of blood sugar levels and high incidence of night-time hypoglycaemia (low blood sugar) in young people with type 1 diabetes (T1D) make achieving the treatment goals in this population extremely challenging.
- Trial name
- NCT01074801
- Testing
- Closed-loop insulin delivery, Standard insulin pump treatment
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Type 1 Diabetes
Closing the Loop in Youth With Type 1 Diabetes in the Home Setting
Type 1 diabetes (T1D) is one of the most common chronic childhood diseases requiring life-long insulin therapy. Children and adolescents with T1D need regular insulin injections or the continuous insulin delivery using an insulin…
- Trial name
- NCT01221467
- Testing
- Overnight closed-loop
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Cambridge
Diabetes Mellitus, Type 1
Closed-Loop Control in Young Children 5-8 Years Old Using DiAs Platform
The overall aim of this proposed research is to determine the safety, feasibility and efficacy (AP vs at home use of SAP) of the Diabetes Assistant (DiAs) controller in day and night closed-loop control in young children 5-8…
- Trial name
- NCT02750267
- Testing
- Diabetes Assistant (DiAs) with Closed-Loop
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Glycemic Outcomes and Safety With Minimed 780G System in Children With Type 1 Diabetes Aged 2-6 Years
The purpose of this study is to evaluate the effectiveness of advanced hybrid-closed loop system, Minimed 780G to glycemic control and safety in children aged 2-6 years with type 1 diabetes.
- Trial name
- NCT04949022
- Testing
- Medronic 780G insulin pump
- Where
- Finland
- Volunteers
- 38 people
- Sponsor
- Helsinki University Central Hospital
Type 1 Diabetes
Technology Knowledge Optimization in Type 1 Diabetes (TeKnO T1D): Parents
This study aims to identify the unmet psychoeducational needs of parents of children 8-12 years of age using insulin pump and CGM for pediatric T1D management and to leverage that information to develop an innovative app-based…
- Trial name
- TeKnO T1D (NCT05300022)
- Testing
- TeKnO T1D: Parents
- Where
- United States
- Sponsor
- Children's Hospital of Philadelphia
Type 1 Diabetes Mellitus
The Artificial Pancreas in Very Young Children With T1D - Pilot (KidsAP01)
The suggested clinical trial is part of the KidsAP project funded by the European Commission's Horizon 2020 Framework Programme.
- Trial name
- NCT03101865
- Testing
- FlorenceM
- Where
- 7 sites in Austria, Germany and 2 more
- Volunteers
- 24 people
- Sponsor
- University of Cambridge
Type 1 Diabetes Mellitus
Real-World Evaluation of TouchCare Nano in Pediatric Type 1 Diabetes
The goal of this observational study is to learn how well the TouchCare Nano automated insulin delivery system works and how safe it is for children and adolescents with type 1 diabetes in everyday medical care.
- Trial name
- NANO-KIDS (NCT07425912)
- Where
- 3 sites in Italy
- Volunteers
- 76 people
- Sponsor
- University of Campania Luigi Vanvitelli
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 24 Hours in Adults and Adolescents With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT01754337
- Testing
- Closed-loop system
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Diabetes Mellitus, Type 1
Automated Insulin Delivery for Type 1 Diabetes - Beyond Glucose Metrics
The goal of this clinical trial is to determine if transitioning to automated insulin delivery (AID) systems, can improve objectively measured sleep quality and quantity and alleviate cardiovascular risk factors in both children…
- Trial name
- AID-BEYOND (NCT06469593)
- Testing
- Automated insuling delivery system
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes
Cross-over Study to Evaluate the Safety and Efficacy of Night Closed-loop Control Using the MD-Logic Automated Insulin Delivery System Compared to Sensor Augmented Pump Therapy in Poorly Controlled Patients With Type 1 Diabetes
The MD-Logic Automated Insulin Delivery System is intended for patients with type 1 diabetes mellitus for subcutaneous infusion of insulin and the continuous measurement of interstitial glucose to aid in the management of their…
- Trial name
- NCT02733211
- Testing
- MD- Logic Closed Loop System, sensor augmented pump therapy
- Where
- 2 sites in Germany, Israel
- Sponsor
- Rabin Medical Center
Type 1 Diabetes Mellitus
Glycemic Control and the Brain in Children With Type 1 Diabetes
The purpose of this study is to determine if improving diabetes control by better controlling blood sugars, will help improve or normalize brain function as compared to routine diabetes care.
- Trial name
- NCT03428932
- Testing
- Closed Loop (Medtronic 670G), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Infant,Premature
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
Extremely low gestational age neonates (ELGANs), i.e. those born at <28 weeks, frequently experience intermittent hypoxemic/hyperoxemic episodes.
- Trial name
- FiO2-C (NCT03168516)
- Testing
- closed-loop automatic control of the inspiratory fraction of oxygen (FiO2-C)
- Where
- 32 sites in China, Germany and 2 more
- Volunteers
- 1,065 people
- Sponsor
- University Hospital Tuebingen
Type 1 Diabetes
Inpatient Evaluation of an Automated Closed-Loop Control-to-Range System
The purpose of this study is to test an insulin management system ("Control-to-Range (CTR) system") in an inpatient setting to see if the system is safe and effective enough to test in a future at-home study.
- Trial name
- CTR (NCT01271023)
- Testing
- Control-to-Range Automated Insulin Management System
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 57 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Feasibility Studies of Personalized Closed Loop
This is a single arm study comprised of a series of feasibility studies.
- Trial name
- NCT04203823
- Testing
- Cloud-based Digital Twin and Meal Prediction algorithms
- Where
- 12 sites in United States
- Volunteers
- 126 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type 1 Diabetes
The Insulin-Only Bionic Pancreas Pivotal Trial
This multi-center randomized control trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas (BP) System versus Usual Care (UC) during a 13-week study period.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT04200313
- Testing
- Bionic Pancreas (BP) with Aspart or Lispro, Bionic Pancreas with Fiasp (BPFiasp), Usual Care (UC)
- Where
- 16 sites in United States
- Volunteers
- 440 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Comparison of Two Closed-Loop Strategies for Glucose Control in Type 1 Diabetes The DREMED Trail- 2
The purpose of the study is to compare two closed-loop strategies in terms of glycemic control in Type 1 Diabetes during a camp setting. The proposed study is a four-segment feasibility study.
- Trial name
- NCT02776696
- Testing
- Advanced Hybrid Closed Loop System, Hybrid Closed Loop System
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Rabin Medical Center