Clinical trials: Closed-Loop
Type 1 Diabetes Mellitus
Closed-Loop Insulin Delivery in Children Less Than 7 Years of Age
The investigators are conducting this study to find out whether a new device can control blood sugar levels in children who have Type 1 diabetes.
- Trial name
- NCT01421225
- Testing
- Closed-loop Insulin Pump therapy, Standard Insulin Pump Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes Mellitus
Closed Loop Control in Adolescents Using Heart Rate as Exercise Indicator
The purpose of this study is to see if the Artificial Pancreas (AP) Platform can successfully control blood sugar in people with type 1 diabetes mellitus on insulin pump therapy in a hospital setting.
- Trial name
- NCT01945060
- Testing
- heart rate Control to Range System (hrCTR) using DiAs Platform, DiAs Control-to-Range System not informed for heart rate
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Marc Breton
Diabetes Mellitus, Type 1, Obesity
Body Mass Index and Growth Parameters Evolution in Children Treated With Hybrid Closed Loop System for Type 1 Diabetes
Overweigth and obesity are commonly diagnosed in children with type 1 diabetes, and frequently an increase of wiegth and BMI is observed after diagnoses.
- Conditions
- Diabetes Mellitus, Type 1, Obesity, Overweight, Child Obesity
- Trial name
- NCT06185348
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Diabetes Mellitus, Type 1
Comparison With Observational Methods and Performance Assessment From Real-life Experience of Closed-Loop Insulin Delivery Systems
This study aims to compare glycemic control obtained under closed loop depending on the system : Smartguard (Medtronic 780) versus Control IQ (Tandem) in patients with diabetes type 1.
- Trial name
- COMPARE-CLIDS (NCT05932966)
- Testing
- Insulin closed-loop delivery system
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Centre Hospitalier Sud Francilien
Diabetes Type 1
Impact of the Mylife CamAPS FX System With the DEXCOM G6 Sensor on T1D Patients in France
This is a non-interventional, longitudinal, prospective, multicenter, post market-registration and national study conducted in France.
- Trial name
- EPICAM-G6 (NCT07048795)
- Testing
- No Intervention: Observational Cohort
- Where
- 22 sites in France
- Volunteers
- 125 people
- Sponsor
- mylife Diabetes Care AG
Type 1 Diabetes
Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy
"Closed loop artificial pancreas" systems have been under development for the control of blood sugars in those living with diabetes.
- Trial name
- NCT01945099
- Testing
- ePID closed loop system, hyaluronidase, Lispro-PH20
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Diabetes Mellitus, Diabetes Mellitus, Type 1
Day and Night Closed-loop in Young People With Type 1 Diabetes
The main study objective is to determine whether 24/7 automated closed-loop glucose control combined with low glucose feature will improve glucose control as measured by HbA1c.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- DAN05 (NCT02925299)
- Testing
- FlorenceM (US) and FlorenceX (UK), Insulin pump therapy
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 133 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Diabetes Mellitus, Type 1
Home Testing of Day and Night Closed Loop With Pump Suspend Feature
The main study objective is to determine whether day and night automated closed loop glucose control combined with pump suspend feature will improve glucose control and reduce the burden of hypoglycaemia compared to sensor…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Endocrine System Diseases
- Trial name
- APCam11 (NCT02523131)
- Testing
- FlorenceM, Medtronic insulin pump 640G
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 84 people
- Sponsor
- University of Cambridge
Obesity, Health Behavior
An Integrated Closed-loop Feedback System for Pediatric Cardiometabolic Disease
The high prevalence and burden of cardiometabolic disease underlie the urgent need to identify novel approaches to managing and preventing cardiometabolic disease and risk.
- Trial name
- STRIVE (NCT02659163)
- Testing
- mHealth wristband, mHealth scale, EMA
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Epilepsy
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT06898138
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Persistent Pulmonary Hypertension of the Newborn, Inhaled Nitric Oxide
Close Loop Smart Weaning for INO With PPHN
In contemporary clinical practice concerning the administration of inhaled nitric oxide (iNO) within neonatal intensive care units (NICUs), a stepwise reduction approach is frequently employed in accordance with established…
- Trial name
- NCT06832163
- Testing
- Nitric Oxide Generation and Delivery System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Diabetes Mellitus, Type 1 Diabetes
The Insulin-Only Bionic Pancreas Pivotal Trial
This multi-center randomized control trial (RCT) will compare efficacy and safety endpoints using the insulin-only configuration of the iLet Bionic Pancreas (BP) System versus Usual Care (UC) during a 13-week study period.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 1
- Trial name
- NCT04200313
- Testing
- Bionic Pancreas (BP) with Aspart or Lispro, Bionic Pancreas with Fiasp (BPFiasp), Usual Care (UC)
- Where
- 16 sites in United States
- Volunteers
- 440 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Evaluation of Minimed 670G in T1D Patients on Multiple Daily Injection
Introduction. Sensor Augmented Pump has demonstrated superiority over insulin pump and Multiple Daily Injection (MDI) in achieving optimal glucose control and can improve quality of life in Type 1 Diabetes (T1D) patients.
- Trial name
- NCT03755479
- Testing
- Hybrid Closed Loop Insulin Pump Minimed 670G
- Where
- Qatar
- Volunteers
- 30 people
- Sponsor
- Sidra Medicine
Respiratory Distress Syndrome, Hyperoxia
Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care
Nearly forty years ago Berran and coworkers tested an analog oxygen controller to maintain incubator oxygen levels for infants suffering neonatal respiratory disease in order to prevent hyperoxia.
- Conditions
- Respiratory Distress Syndrome, Hyperoxia, Prematurity
- Trial name
- NCT00887731
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Type 1 Diabetes Mellitus
Closed-loop Response to Unannounced Mixed and Carbohydrates-rich Breakfasts
The development of advanced hybrid closed-loop (a-HCL) systems represents a significant step toward in improving glucose control and reducing user-dependent variability, especially In pediatric patients.
- Trial name
- CRUMB (NCT07455643)
- Testing
- Unannounced meal
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Catania
Type1diabetes
Assessment of Two Insulin Pump Insulin Delivery Systems in Type 1 Diabetes.
This is a study of the Minimed 670G 4.0 insulin pump, assessing the efficacy of the Advanced Hybrid Closed Loop (AHCL) algorithm in controlling blood glucose levels in Type 1 Diabetes.
- Trial name
- NCT04073576
- Testing
- AHCL, SAP+PLGM
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- Christchurch Clinical Studies Trust Ltd
Type 1 Diabetes
The Pediatric Artificial Pancreas Automated Initialization Trial
The goal of this clinical trial is to obtain safety data and exploratory glycemic control data from use of an at-home closed loop control (CLC) system (t:slim X2 with Control-IQ Technology) with periodic parameter adjustments…
- Trial name
- PEDAP-AI (NCT06017089)
- Testing
- AI-based Advisor system
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Marc Breton
Biomedical Technology, Type 1 Diabetes
Analysis of Glycemic Control in Type 1 Diabetes Patients Using Hybrid Closed Loop Insulin Pump Therapy (Medtronic 670G)
Observational study of patients at Boston Childrens Hospital with type 1 diabetes (T1D) who elected to treat their diabetes with the Medtronic 670 G hybrid closed loop insulin pump.
- Trial name
- NCT04051632
- Testing
- Medtronic 670G insulin pump
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes
Simple Meal Management Using Automated Insulin Delivery System
Carbohydrate counting is an essential component of diabetes management in both adults and children, and together with an intensive insulin plan and increased blood glucose monitoring was associated with lower HbA1c.
- Trial name
- SMMAID (NCT06130215)
- Testing
- Simple meal management, Precise meal management
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Diabetes Mellitus, Type 1
Evaluating the Efficacy and Quality of Life Impact of Transitioning to Advanced Hybrid Closed-Loop Insulin Pump Therapy in Romanian Children With Type 1 Diabetes Mellitus
The proposed study aims to demonstrate the potential benefits of transitioning T1DM children from predictive low glucose suspend insulin pump therapy to advanced hybrid closed-loop insulin pump therapy in Romania.
- Trial name
- NCT06326489
- Testing
- Switching to the Medtronic 780G insulin pump
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- ELIAS Emergency University Hospital